Protein Alignment SMARCAL1 and Smarcal1

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_001101692.1
• Gene: Smarcal1 / 316477
• RGDID: 1306134
• Length: 910
• Species: Rattus norvegicus
• Alignment Length: 959
• Identity: 704/959 - (73%)
• Similarity: 773/959 - (80%)
• Gaps: 56/959 - (5%)

Human     1 MSLPLTEEQRKKIEENRQKALARRAEKLLAEQHQRTSSGTSIAGNPFQAKQGPSQNFPRESCKPV 65
            ||||||||||||||||||||||||||||.|||.|.|:||:| |..|.|.||....|.|.|..||.
  Rat     1 MSLPLTEEQRKKIEENRQKALARRAEKLWAEQPQSTASGSS-AARPSQCKQNSLLNLPAEPSKPE 64

Human    66 SHGVIFKQQNLSSSSNADQRPHDSHSFQ------AKGIWKKPEEMPTACPGHSPRSQMALTGISP 124
            .|..|.|.|||::|..|.||||.|..||      |||:||...:|..|||.
  Rat    65 GHATISKGQNLNNSLPAAQRPHSSPCFQPSTAEEAKGLWKSEGKMSAACPN-------------- 115

Human   125 PLAQSPPEVPKQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKPKSSQETPAHSSGQPPRDAK 189
               .|||||..||||..:..:||                      |:::|:|.|......|||.|
  Rat   116 ---PSPPEVSNQQLLGSKSSEGH----------------------PQATQDTAASCPRPFPRDPK 155

Human   190 LEAKTAKASPSGQNISYIHSSSESVTPRTEGRLQQKSGSSVQKGVNSQKGKCVRNGDRFQVLIGY 254
            ||||..:.|.|||:||....:....||:|:||..:...:|.|| .:..:|.|:|.||||:|.|||
  Rat   156 LEAKAGRPSTSGQSISDTFYALGEKTPKTDGRPAKALQTSPQK-ASCLRGMCLRTGDRFRVKIGY 219

Human   255 NAELIAVFKTLPSKNYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPLEWAYGSSESPSTSSEGQ 319
            |.|||.|||:|||:.||..||||:|||:||.|||||.:.|.||:|||||...|:.        ||
  Rat   220 NKELIEVFKSLPSRRYDSFTKTWDFSMSDYRALMKAVERLSTVSLQPLEEVDGTG--------GQ 276

Human   320 AGLPSAPSLSFVKGRCMLISRAYFEADISYSQDLIALFKQMDSRRYDVKTRKWSFLLEEHSKLIA 384
            ..|||||||:||.|||||||||.||.||.||:.:|||||||:||.||.|||||:||||||:||||
  Rat   277 TSLPSAPSLTFVTGRCMLISRARFEVDIGYSEVVIALFKQMESRNYDPKTRKWNFLLEEHNKLIA 341

Human   385 KVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPEADLSEVDPKLVSNLMPFQRAGVNFAIA 449
            :.|.|.||||||||.||||||||||:||||....||||||||.||.|||||||||||.||:|||:
  Rat   342 RSRELKQVQLDPLPKTLTLAFASQLEKTSLQSKADVPEADLSGVDAKLVSNLMPFQREGVSFAIS 406

Human   450 KGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVVVT 514
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||:.||||||
  Rat   407 KRGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPEDINVVVT 471

Human   515 GKDRLTAGLINIVSFDLLSKLEKQLKTPFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLS 579
            ||.||||||:||||||||||||||||||||||||||||||||.:|||||||:|:|||||||||||
  Rat   472 GKGRLTAGLVNIVSFDLLSKLEKQLKTPFKVVIIDESHFLKNIKTARCRAAVPILKVAKRVILLS 536

Human   580 GTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLEEAVMLR 644
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
  Rat   537 GTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRLPWGWDYSGSSNLGELKLLLEEAVMLR 601

Human   645 RLKSDVLSQLPAKQRKIVVIAPGRINARTRAALDAAAKEMTTKDKTKQQQKDALILFFNRTAEAK 709
            ||||||||||||||||:||:.||||:.|.:|||||||||| ||||||||||:||::|||||||||
  Rat   602 RLKSDVLSQLPAKQRKMVVVNPGRISTRAKAALDAAAKEM-TKDKTKQQQKEALLVFFNRTAEAK 665

Human   710 IPSVIEYILDLLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLS 774
            ||.||||||||||||||||||||||||:||||.:|||||:||||||||||.||:|||||||||||
  Rat   666 IPCVIEYILDLLESGREKFLVFAHHKVLLDAIAKELERKNVQHIRIDGSTPSADREDLCQQFQLS 730

Human   775 ERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTAD 839
            :.|.||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||
  Rat   731 KGHTVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTNSVGIHYLVAKGTAD 795

Human   840 DYLWPLIQEKIKVLAEAGLSETNFSEMTESTDYLYKDPKQQKIYDLFQKSFEKEGSDMELLEAAE 904
            ||||||||||||||.||||||||||||||:||||||||||:.||.|||:|||.:|:|||.|||||
  Rat   796 DYLWPLIQEKIKVLGEAGLSETNFSEMTEATDYLYKDPKQKTIYSLFQQSFEDDGNDMEFLEAAE 860

Human   905 SFDPGSASGTSGSSSQNMGDTLDESSLTASPQKKRRFEFFDNWDSFTSP 953
            ||:.||.|||||:|||.:||..||::|..||.|||||||||||||||||
  Rat   861 SFELGSTSGTSGNSSQELGDITDENALADSPPKKRRFEFFDNWDSFTSP 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		18/18 (100%)
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30		24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238		81/216 (38%)
		HARP	248..302	CDD:462166	36/53 (68%)
		HARP	343..397	CDD:462166	39/53 (74%)
		HepA	<423..856	CDD:440319	394/432 (91%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	195/208 (94%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		16/16 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934		18/29 (62%)
Smarcal1	NP_001101692.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..170		97/208 (47%)
		Mediates interaction with RPA2. /evidence=ECO:0000250	2..30		27/27 (100%)
		Mediates interaction with RPA2. /evidence=ECO:0000250|UniProtKB:Q9NZC9	5..30		24/24 (100%)
		HARP	213..267	CDD:462166	36/53 (68%)
		HepA	<323..807	CDD:440319	434/484 (90%)
		DEXHc_HARP_SMARCAL1	393..602	CDD:350768	195/208 (94%)
		DESH box	506..509		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NZC9	601..618		16/16 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..890		15/24 (63%)