DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMARCAL1 and hrp3

DIOPT Version :10

Sequence 1:NP_054859.2 Gene:SMARCAL1 / 50485 HGNCID:11102 Length:954 Species:Homo sapiens
Sequence 2:NP_001342861.1 Gene:hrp3 / 2543064 PomBaseID:SPAC3G6.01 Length:1388 Species:Schizosaccharomyces pombe


Alignment Length:1014 Identity:214/1014 - (21%)
Similarity:372/1014 - (36%) Gaps:307/1014 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   132 EVP--KQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKPKSSQETPAHSSGQPPRDAKLEAKT 194
            |.|  ||::.......|.| :..:::.|.:.:|....|.:...::..|........::....:|.
pombe    25 ETPNLKQEMSESPSNSGVA-SKRKLQSTEWLDPELYGLRRSGRTRSNPGRYVDTDDQEDVFPSKH 88

Human   195 AKASPSGQNISY------IHSSSESV--------------TPRTEGRLQQKSGSSVQKGVNSQKG 239
            .|.:.:|.:.|.      :...:|||              ||:...| |:||.:.||..:.    
pombe    89 RKGTRNGSSFSRHRTIRDLDDEAESVTSEESESDDSSYGGTPKKRSR-QKKSNTYVQDEIR---- 148

Human   240 KCVRNGDRFQVLIGYNAELIAVFKTLPSK--NYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPL 302
                                  |.:..||  ||:.|....:|...:...:              .
pombe   149 ----------------------FSSRNSKGVNYNEDAYFESFEEEEEEEM--------------Y 177

Human   303 EWAYGSSESPSTSS-----------EGQAGLPSAPS------------------------LSFVK 332
            |:|...||.|..:.           ||..|  |.||                        :|.::
pombe   178 EYATEVSEEPEDTRAIDVVLDHRLIEGHDG--STPSEDYEFLIKWVNFSHLHCTWEPYNNISMIR 240

Human   333 G---------RCMLISRAYFEADISYSQDLIAL-------------FKQMD-----------SRR 364
            |         :.:|:.|...|...:..:|:.|:             :||:|           |..
pombe   241 GSKKVDNHIKQVILLDREIREDPTTTREDIEAMDIEKERKRENYEEYKQVDRIVAKHLNSDGSVE 305

Human   365 YDVKTRK--WSFLLEEHSKLIAKVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLTP--------D 419
            |.||.::  :.|...|.|.:|           :|:..|...||.   ::...:|:|        .
pombe   306 YLVKWKQLLYDFCTWEASSII-----------EPIAATEIQAFQ---EREESALSPSRGTNYGNS 356

Human   420 VPEADLSEVDPKLVS--NLMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAICIAAF----Y 475
            .|:....|..|..::  .|..||..|||   :...|....:|||:||||||:|.:...::    .
pombe   357 RPKYRKLEQQPSYITGGELRDFQLTGVNWMAYLWHKNENGILADEMGLGKTVQTVAFLSYLAHSL 421

Human   476 RKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVV---------------VTGKDRLTAGLIN 525
            |:..|.|||||.|....|::....|...:  :||:.:               |.|..::...|: 
pombe   422 RQHGPFLVVVPLSTVPAWQETLALWASDM--NCISYLGNTTSRQVIRDYEFYVDGTQKIKFNLL- 483

Human   526 IVSFDLLSKLEKQLKT-PFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAE 589
            :.:::.:.|....|.. .::.:.|||:|.||||.:: ...|:...|.:.| :|::|||..:...|
pombe   484 LTTYEYVLKDRSVLSNIKWQYMAIDEAHRLKNSESS-LYEALSQFKNSNR-LLITGTPLQNNIRE 546

Human   590 LYTQIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLE--EAVMLRRLKSDVLS 652
            |...:..:.|..|.......|...|.::..:            ::.|.|  :..:|||||.||..
pombe   547 LAALVDFLMPGKFEIREEINLEAPDEEQEAY------------IRSLQEHLQPYILRRLKKDVEK 599

Human   653 QLPAKQRKIVVIAPGRINARTRAALDAAA----KEMTTKD---KTKQQQKDALILFFNRTAEAKI 710
            .||:|..:|:           |..|....    |.:.|::   .|:.....:.|...|...|.|.
pombe   600 SLPSKSERIL-----------RVELSDLQMYWYKNILTRNYRVLTQSISSGSQISLLNIVVELKK 653

Human   711 PSVIEYILD-----------------------LLESGR---------------EKFLVFAHHKVV 737
            .|...|:.|                       ::.||:               .:.|:|:....:
pombe   654 ASNHPYLFDGVEESWMQKINSQGRRDEVLKGLIMNSGKMVLLDKLLSRLRRDGHRVLIFSQMVRM 718

Human   738 LDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQL-SERHAVAVLSITAANMGLTFSSADLVVF 801
            ||.:...|..:...|.|:||:..:|.|......|.. :....|.:||..|..:|:...:||.|:.
pombe   719 LDILGDYLSLRGYPHQRLDGTVPAAVRRTSIDHFNAPNSPDFVFLLSTRAGGLGINLMTADTVII 783

Human   802 AELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLAEAGLSETNFSEM 866
            .:..|||...:||..|.|||||.:.|.::.|::|.|.::.:  |.:.:.|::.|..:.....::.
pombe   784 FDSDWNPQADLQAMARAHRIGQKNHVMVYRLLSKDTIEEDV--LERARRKMILEYAIISLGVTDK 846

Human   867 TESTDYLYKDPKQQKI-------------YDLFQ-KSFEKEGSDM---ELLEAAESFDPGSASGT 914
                   .|:.|..|.             .::|: ::.:|:..||   |:||.||..|  :::..
pombe   847 -------QKNSKNDKFSAEELSAILKFGASNMFKAENNQKKLEDMNLDEILEHAEDHD--TSNDV 902

Human   915 SGSSSQNMGDTLDESSLTASPQKKRRFEFFD-----NWD 948
            .|:|   ||   .|..|       ::||..|     :||
pombe   903 GGAS---MG---GEEFL-------KQFEVTDYKADVSWD 928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMARCAL1NP_054859.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198 5..30
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..238 25/127 (20%)
HARP 248..302 CDD:462166 7/55 (13%)
HARP 343..397 CDD:462166 14/79 (18%)
HepA <423..856 CDD:440319 121/505 (24%)
DEXHc_HARP_SMARCAL1 436..645 CDD:350768 58/233 (25%)
DESH box 549..552 2/2 (100%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831 644..661 9/16 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 904..934 8/29 (28%)
hrp3NP_001342861.1 CD1_tandem_CHD1_yeast_like 189..250 CDD:349312 8/62 (13%)
CD2_tandem 286..339 CDD:349306 15/66 (23%)
PLN03142 339..>895 CDD:215601 136/592 (23%)
Cdh1_DBD_1 997..1081 CDD:408024
DUF4208 1300..1384 CDD:464035
Blue background indicates that the domain is not in the aligned region.

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