Protein Alignment SMARCAL1 and snf21

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_594861.1
• Gene: snf21 / 2542638
• PomBaseID: SPAC1250.01
• Length: 1199
• Species: Schizosaccharomyces pombe
• Alignment Length: 799
• Identity: 175/799 - (21%)
• Similarity: 301/799 - (37%)
• Gaps: 238/799 - (29%)

Human   334 RCMLISRAYFE------ADISYSQDLIALFKQMDSRRY-----DVKTRKWSFLLEEHSKLIAKVR 387
            |.:|...::.|      |:.:..|.|.|| |:.|...|     ..|..:.:.||.:....:..:.
pombe   298 RAVLAYHSHIEKEEQRRAERNAKQRLQAL-KENDEEAYLKLIDQAKDTRITHLLRQTDHYLDSLA 361

Human   388 CLPQVQLDPLPTTLTLAFASQLKKTSLSLTPD---VPEAD-----------LSEV---DPKLV-- 433
            ...:||            .||..:::.....|   .||.|           :.||   .|.::
pombe   362 AAVKVQ------------QSQFGESAYDEDMDRRMNPEDDRKIDYYNVAHNIREVVTEQPSILVG 414

Human   434 SNLMPFQRAGVNFAIAKGGRLL---LADDMGLGKTIQAICIAAFY----RKEWPLLVVVPSSVRF 491
            ..|..:|..|:.:.|:.....|   |||:||||||||.|.:....    |:..|.||:||.|...
pombe   415 GKLKEYQLRGLQWMISLYNNHLNGILADEMGLGKTIQTISLITHLIEKKRQNGPFLVIVPLSTLT 479

Human   492 TWEQAFLRWLPSLSPDCINVVVTGKDRLTAGL----------INIVSFDLLSKLEKQLKTPFK-- 544
            .|...|.||.||:    :.:|..|..::...|          :.:.:::.:.| ::.|.:..|
pombe   480 NWTMEFERWAPSI----VKIVYKGPPQVRKALHPQVRHSNFQVLLTTYEYIIK-DRPLLSRIKWI 539

Human   545 VVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFG 609
            .:||||.|.:||:: ::....:.....::..::|:|||..:...||:..:..|.|..|....:|.
pombe   540 YMIIDEGHRMKNTQ-SKLTNTLTTYYSSRYRLILTGTPLQNNLPELWALLNFVLPRIFNSIKSFD 603

Human   610 LRYCDAKRMPWGWDYSGSSNLG---ELKLLLEEAV-------------MLRRLKSDVLSQLPAKQ 658
                       .|..:..:|.|   :::|..||::             :|||||.||.::||.|.
pombe   604 -----------EWFNTPFANTGGQDKMELTEEESLLVIRRLHKVLRPFLLRRLKKDVEAELPDKV 657

Human   659 RKIVVIAPGRINARTRAALDAAAKEM--------------TTKDKT--KQQQKDALIL------- 700
            .|::           |..:....:::              ..:.||  |..|...:.|
pombe   658 EKVI-----------RCQMSGLQQKLYYQMKKHGMLYVEDAKRGKTGIKGLQNTVMQLKKICNHP 711

Human   701 FFNRTAEAKI-PSVIEY-----------ILD-----LLESGREKFLVFAHHKVVLDAITQELERK 748
            |.....|..| |:...|           :||     |..|| .:.|:|.....:::.:...|..:
pombe   712 FVFEDVERSIDPTGFNYDMLWRVSGKFELLDRILPKLFRSG-HRILMFFQMTQIMNIMEDYLHYR 775

Human   749 HVQHIRIDGSTSSAEREDLCQQFQLSERHA-VAVLSITAANMGLTFSSADLVVFAELFWNPGVLI 812
            ..:::|:||||.:.:|..|...|....... :.:||..|..:||...:||.|:..:..|||...:
pombe   776 QWRYLRLDGSTKADDRSKLLGVFNDPTAEVNLFLLSTRAGGLGLNLQTADTVIIFDSDWNPHQDL 840

Human   813 QAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKV---LAEAG----------------- 857
            ||:||.||||||..|.|:.|:.:.:.::.:....|.|:.:   :.:||
pombe   841 QAQDRAHRIGQTKEVRIYRLITEKSVEENILARAQYKLDIDGKVIQAGKFDNKSTPEEREAFLRS 905

Human   858 -LSETN-----------------------------FSEMTESTD--------------------- 871
             |...|                             |.:|||..:
pombe   906 LLENENGEEENDEKGELDDDELNEILARGDDELRLFKQMTEDLERESPYGKNKEKERLIQVSELP 970

Human   872 YLYKDPKQQKIYDLFQKS-------------FEKEGSDMELLEAAESFDPGSASGTSGSSSQNMG 923
            ..|:..:.:|..||.|:.             :::...|.:.:  ||......|..|.|...:|:.
pombe   971 EFYQREEPEKTTDLLQEEPLGRGARRRTPVVYDEAVRDAQWM--AEMDMESEARPTRGRPKRNIA 1033

Human   924 DTLDES---SLTASPQKKR 939
             ::||:   :|...|:|||
pombe  1034 -SVDETPALTLNGKPKKKR 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238
		HARP	248..302	CDD:462166
		HARP	343..397	CDD:462166	14/64 (22%)
		HepA	<423..856	CDD:440319	127/527 (24%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	60/243 (25%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		9/16 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934		8/32 (25%)
snf21	NP_594861.1	HSA	256..328	CDD:214727	8/30 (27%)
		PLN03142	305..>947	CDD:215601	153/683 (22%)
		SnAC	949..1012	CDD:464219	6/62 (10%)
		Bromo_SNF2	1066..1168	CDD:99950