Protein Alignment SMARCAL1 and rrp1

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_594246.1
• Gene: rrp1 / 2542440
• PomBaseID: SPAC17A2.12
• Length: 897
• Species: Schizosaccharomyces pombe
• Alignment Length: 1009
• Identity: 191/1009 - (18%)
• Similarity: 338/1009 - (33%)
• Gaps: 381/1009 - (37%)

Human   126 LAQSPPEVPKQQLLSYELGQGHAQASPEIRFTPFANPTHKPLAKP-----KSSQETPAHSSGQPP 185
            |:..||:...|||.:.|                       .||:.     .||..:.|.||....
pombe     4 LSAYPPQSTFQQLQNDE-----------------------ELARRLQDEWNSSSPSSAPSSSSSQ 45

Human   186 RDAKLEAKTAKASPSGQNISYI-----HSSSESVTP---RTEGRLQQKSGSSVQKGVNSQKGKCV 242
            ...:|:.:.|::..:.|:.||.     |..|::.|.   .|..|.:||.
pombe    46 NQVELDEQFARSLQNSQSSSYSLPPFDHPPSKNPTSSSLSTRKRWRQKR---------------- 94

Human   243 RNGDRFQVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPLEWAYG 307
                            :..||..|   :.|.|:..:...|        :.|||::.        .
pombe    95 ----------------LWSFKNFP---FRPPTRLTSTPSN--------SSSLPSIP--------S 124

Human   308 SSESPSTSSEGQAGLPSAPSLSFVKGRCMLISRAYFEADISYSQDLIALFKQMDSRRYDVKTRKW 372
            ||.:||.||     :|...|                    |.|.|:.::....|   :.:.....
pombe   125 SSSTPSISS-----IPHTTS--------------------SVSNDIPSVLGSSD---HPIDLDNP 161

Human   373 SFLLEEHSKLIAKVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPEADLSEVDPKLVSNLM 437
            ..|....|.:.||       ||..|||.|....:|.|...::|.....|..  .:|.|:.|:..:
pombe   162 EHLTPPSSFITAK-------QLSRLPTPLPPPSSSSLPTGTISTNSFCPYE--RKVQPEHVTKEL 217

Human   438 ----------PF------------QRAGVNFAIAK------------------GGRLLLADDMGL 462
                      ||            |.||:..::..                  ||  ::||||||
pombe   218 HQLLQHNTPSPFDTIDLQLKNEQVQSAGLLVSLLPHQVEGHAWMESMEQSSKCGG--VMADDMGL 280

Human   463 GKTIQAICIAAFYRKEWPL----LVVVPSSVRFTW-EQAFLRWLPSLSPDCINVVV----TGKD- 517
            |||||.|.:....:.:.||    |:||..::...| |:...:..||..   ::|.:    |.|:
pombe   281 GKTIQTIALLLTQKSQDPLRKTNLIVVSVALLHQWAEELSTKVHPSKK---LSVYIHHGSTKKNL 342

Human   518 ---RLTAGLINIVSFDLLSKLEKQ--------------------LKTPFKVVIIDESHFLKNSRT 559
               .|:...:.:.::.:|:...||                    |:|.:..:::||:|.::|..|
pombe   343 DSYELSQYDVVLTTYSMLAYEMKQNDAFNNNNPATATPPPACSLLETSWYRIVLDEAHTIRNRDT 407

Human   560 --ARCRAAMPVLKVAKRVILLSGTPAMSRPAELYT--QIIAVKP--------------------- 599
              |:|...:.    ||....|||||..:...|.|:  :.:.:||
pombe   408 LAAKCCVKLD----AKYRWCLSGTPIQNHIDEFYSLLKFLRIKPYCVWSLFAKDISRPLKSYRAD 468

Human   600 ----------------------------------------------------------------- 599
                                                                             
pombe   469 IVEAALKRLRILLASTVFRRTKETRVNNLPIVNLPPKTIRTVSVNLLPEERALYNEQMSSAQSLV 533

Human   600 -TFFPQFH---AFGLRYCDAKRM------PWGWDYSGSSNLGELK--------------LLLEEA 640
             .:|...|   .:|.......|:      ||....|...|...::              |.:|..
pombe   534 DNYFNNDHDLSRYGFLLVSLLRLRQFCCHPWLVKSSSLDNSFRIRDSENVRNACKSLDPLTIERI 598

Human   641 VMLRRLK---------------------------------------SDVLSQLPAKQRKIV---- 662
            ..|:...                                       |.::::.|..:..||
pombe   599 ATLQDFNCSVCLDPCLAPVFIIPCGHFTCQECMSMLVGQKYGSSSTSTIIAKCPMCRGNIVQDSL 663

Human   663 VIAP------GRINARTRAALDAAAKEMTTKDKTKQQQKDALILFFNR---------TAEAKIPS 712
            |.|.      |.:|:..:..|| ..:..:.::..|.:.::.:...|.:         .:.:|:..
pombe   664 VDATILQAIHGPLNSLKQLELD-MNQSFSEQESIKLRWENRIDQMFTKKFGKRASEWKSSSKLNQ 727

Human   713 VIEYILDLLESGR-EKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSER 776
            ..:.|||::.|.| ||.||::.....|..::..|:.::::|:|.||:.|:.:|:.....|...:.
pombe   728 ARQTILDIIGSKRNEKILVYSQFSQYLCLVSHMLKLENIRHVRYDGTMSANQRQKSLHSFNNDKD 792

Human   777 HAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDY 841
            ..|.::|:.|.::||..:.|:.|:..|.|:||.:..||.|||||:||...|.::..:.|.|.::.
pombe   793 VLVMLVSLKAGSVGLNLTIANHVILQEPFYNPSIEDQAIDRVHRLGQQKPVTVYRFITKDTIEER 857

Human   842 LWPLIQEKIKVLAEA-GLSETNFSEMTESTDYLY 874
            :..:.::|.:::.|| ..:|.|.....:..:.||
pombe   858 IVSVQRKKRQLVKEALDSNENNPLSRLDKEELLY 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238		26/124 (21%)
		HARP	248..302	CDD:462166	9/53 (17%)
		HARP	343..397	CDD:462166	10/53 (19%)
		HepA	<423..856	CDD:440319	124/678 (18%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	66/395 (17%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		2/55 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934
rrp1	NP_594246.1	HepA	<244..874	CDD:440319	120/639 (19%)
		RING_Ubox	603..663	CDD:473075	4/59 (7%)