Protein Alignment SMARCAL1 and hrp1

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_593660.1
• Gene: hrp1 / 2542363
• PomBaseID: SPAC1783.05
• Length: 1373
• Species: Schizosaccharomyces pombe
• Alignment Length: 1087
• Identity: 227/1087 - (20%)
• Similarity: 389/1087 - (35%)
• Gaps: 334/1087 - (30%)

Human    34 QRTSSGTSIAGNPFQAKQGPSQNFPRESCKPVSHGVI------FKQQNLSSSSNADQRPHDSHSF 92
            :.|.:|:::....|    |.:.|     ..|..:|::      ..||:||||:..|
pombe    19 ESTLNGSAVTDPQF----GNTTN-----SLPSMNGLLNHENSFASQQSLSSSAFDD--------- 65

Human    93 QAKGIWKKPEEMPTACPGHSPRSQMALTGISPPLAQSPPEVPKQQLLSYELGQGHAQASPEIRF- 156
                     .|:.|:    :..|.:..:.:|.|....                  ||.|.::|.
pombe    66 ---------SEIVTS----TANSTVVSSALSTPKIDD------------------AQNSDDVRVD 99

Human   157 -TPFANPTHKPLAKPKSSQETPAHSSGQPPRDAKLEAKTAKASPSGQNISYIHSSSESVTPRTEG 220
             |..::...:|:.:..|..|...|....|.:      :.:|.:|. |..|......::...|...
pombe   100 GTRRSSRAKRPVYRDFSYTEIDEHEIPIPKK------RKSKPAPK-QKKSVASDDEDAYDKRHRF 157

Human   221 RLQQKSGSSVQKGVNSQKGKCVR-NGDRF-------------QVLIGYNAELIAVF---KTLPSK 268
            .:...||:.::..:.|.|||.|. |...|             ||...|...:..|.   |...::
pombe   158 SINSASGTEIRTSLRSSKGKSVNYNEQEFYDDFEDEEEEVEEQVEEEYEPIIDFVLNHRKRADAQ 222

Human   269 NYDPDT---------------KTWNFSMNDYSALMKA----------AQSL---------PTVNL 299
            :.||.:               .||    .|||.|...          .|::         ||...
pombe   223 DDDPKSSYQYLIKWQEVSHLHNTW----EDYSTLSSVRGYKKVDNYIKQNIIYDREIREDPTTTF 283

Human   300 QPLEWAYGSSE----------------SPSTSSEGQAGLPSAPSLSFVKGRCMLISRAYFE-ADI 347
            :.:|......|                :..|:.||:...       |||.|.:......:| ||:
pombe   284 EDIEALDIERERKNMLFEEYKIVERIVASETNEEGKTEY-------FVKWRQLPYDNCTWEDADV 341

Human   348 SYSQDLIALFKQMDSRRYDVKTRKWSFLLEEHSKLIAKVRCLPQVQLDPLPTTLTLAFASQLKKT 412
            .||.               .....:.||..|:|..              ||          .|..
pombe   342 IYSM---------------APNEVYQFLQRENSPY--------------LP----------YKGV 367

Human   413 SLSLTPDVPEADLSEVDPKLV--SNLMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAICIA 472
            ..:..|  |...| |..|..:  ..:..||..|:|   :...:....:|||:||||||:|.:|..
pombe   368 FYNTRP--PYRKL-EKQPSYIKGGEIRDFQLTGINWMAYLWHRNENGILADEMGLGKTVQTVCFL 429

Human   473 AF----YRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVVVTGKDRLTAGLINIVSFDL-L 532
            ::    .::..|.|:|||.|....|::....|.|.|:..|    .||.   |....||..::. |
pombe   430 SYLVHSLKQHGPFLIVVPLSTVPAWQETLANWTPDLNSIC----YTGN---TESRANIREYEFYL 487

Human   533 SKLEKQLK-----TPFKVVI---------------IDESHFLKNSRTARCRAAMPVLKVAKRVIL 577
            |...::||     |.::.::               |||:|.||||.:: ....:...:.|.| :|
pombe   488 STNSRKLKFNILLTTYEYILKDKQELNNIRWQYLAIDEAHRLKNSESS-LYETLSQFRTANR-LL 550

Human   578 LSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLE--EA 640
            ::|||..:...||.:.:..:.|         |..|.   |....:|...:....:::.|.|  :.
pombe   551 ITGTPLQNNLKELASLVNFLMP---------GKFYI---RDELNFDQPNAEQERDIRDLQERLQP 603

Human   641 VMLRRLKSDVLSQLPAKQRKIVVI--------------------APGRINARTRAAL-------- 677
            .:|||||.||...||:|..:|:.:                    ..|..:.|.:.:|
pombe   604 FILRRLKKDVEKSLPSKSERILRVELSDMQTEWYKNILTKNYRALTGHTDGRGQLSLLNIVVELK 668

Human   678 ----------DAAAKEMTTKDKTKQQQKDALILFFNRTAEAKIPSVIEYILDLLESGREKFLVFA 732
                      .||.|.|..:..|::.....:|:...:..      :::.:|..|:....:.|:|:
pombe   669 KVSNHPYLFPGAAEKWMMGRKMTREDTLRGIIMNSGKMV------LLDKLLQRLKHDGHRVLIFS 727

Human   733 HHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSER-HAVAVLSITAANMGLTFSSA 796
            ....:|:.:.:.:..:...:.|:||:..::.|......|...:. ..|.:||..|..:|:..::|
pombe   728 QMVRMLNILGEYMSLRGYNYQRLDGTIPASVRRVSIDHFNAPDSPDFVFLLSTRAGGLGINLNTA 792

Human   797 DLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLAEAGLSET 861
            |.|:..:..|||...:||..|.|||||.:.|.::..::|.|.::.:  |.:.:.|::.|..:...
pombe   793 DTVIIFDSDWNPQADLQAMARAHRIGQKNHVNVYRFLSKDTVEEDI--LERARRKMILEYAIISL 855

Human   862 NFSEMTESTDYLYKDPKQQKIYD--------------LF-----QKSFEKEGSDMELLEAAESFD 907
            ..:|.:       |:.|..| ||              :|     ||..|....| ::|..||  |
pombe   856 GVTEKS-------KNSKNDK-YDAQELSAILKFGASNMFKATENQKKLENMNLD-DILSHAE--D 909

Human   908 PGSASGTSGSSSQNMGDTLDESSLTASPQKKRRFEFFD------NWD 948
            ..|::...|:|   ||   .|..|       ::||..|      |||
pombe   910 RDSSNDVGGAS---MG---GEEFL-------KQFEVTDYKAEDLNWD 943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238		37/211 (18%)
		HARP	248..302	CDD:462166	17/103 (17%)
		HARP	343..397	CDD:462166	9/54 (17%)
		HepA	<423..856	CDD:440319	116/503 (23%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	60/238 (25%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		9/16 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934		9/29 (31%)
hrp1	NP_593660.1	CD1_tandem_CHD1_yeast_like	207..266	CDD:349312	10/62 (16%)
		CD2_tandem	302..355	CDD:349306	13/74 (18%)
		PLN03142	377..>909	CDD:215601	131/572 (23%)
		Cdh1_DBD_1	1010..1090	CDD:408024
		CHDCT2	1132..>1159	CDD:462358