Protein Alignment SMARCAL1 and mit1

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_595385.1
• Gene: mit1 / 2541336
• PomBaseID: SPBP35G2.10
• Length: 1418
• Species: Schizosaccharomyces pombe
• Alignment Length: 676
• Identity: 172/676 - (25%)
• Similarity: 276/676 - (40%)
• Gaps: 167/676 - (24%)

Human   358 KQMDSRRYDVKTRKWSFLLEEHSKLIAKVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLTPDVPE 422
            |:.|..|:....:.:|.|||          ||   .::..||.              |:..|:|.
pombe   502 KETDRNRWKAWLKGYSDLLE----------CL---WIEKAPTA--------------SINIDLPF 539

Human   423 ADLS-EVDPKLV--SNLMPFQRAGVNFAIAK---GGRLLLADDMGLGKTIQAICIAA--FYR-KE 478
            .:|. ...|..:  ..|||:|..|:|:...:   ....:|||:||||||:|.|...:  ||| |.
pombe   540 TNLEWHSQPSFIKGGTLMPYQLKGLNWLYLRWYTHHPCILADEMGLGKTVQVISFISVLFYRHKC 604

Human   479 WPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVVV-TGKDRLTA---GLIN-----IVSFDLL-- 532
            :|:||:||.:....||:...:|.|.|.   |||:| :.|:|...   .|||     .||..:|
pombe   605 FPVLVIVPHATVANWERELKKWAPFLQ---INVLVGSEKNRSLVRDYRLINQKDPKHVSTHVLVI 666

Human   533 --SKLEKQL----KTPFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELY 591
              |.:|:::    |..:||:|:||...|||.:::.......|....|  :||:|||..:...||:
pombe   667 SASNVEREISLLRKFQWKVLIVDEGQRLKNDQSSLFYYLSSVKSDFK--LLLTGTPLQNNVRELF 729

Human   592 TQIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYS--GSSNLGELKLLLEEAVMLRRLKSDVLSQL 654
            ..:..:.|.   :.:|..|.    ||      ||  .:..:.||..:| :...|||:||:||...
pombe   730 NLLQFLNPM---KINAAELE----KR------YSIIDTEKVTELHQIL-KPFFLRRVKSEVLDNF 780

Human   655 PAKQRKIVVIAPGRI-----------------NARTRAALDAAAKEMTTK-DKTKQQQKDAL--- 698
            |.|...|:.::...:                 |....|...::..:.||. :....|.:..|
pombe   781 PTKVEVIIPLSMTPVQKGLYKSILSKNLSLLRNITGYANTSSSGGQRTTSLNNILMQLRKTLAHP 845

Human   699 ILFFNRTAEAKIPSVIEYILDLLESGREKFLVF---------AHHKVV--------LDAITQELE 746
            .::.....:..:|  .|..:..||....|||:.         ..|:::        ||.:....|
pombe   846 YIYSPDIEDRNLP--YELAMRSLEEASCKFLILRLLVPKLITRGHRILLFSQFIQQLDILEDWFE 908

Human   747 RKHVQHIRIDGSTSSAEREDLCQQFQL-SERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGV 810
            .|::.:.|.||::|..||:.....|.. :...:..:||..|..:|:..:|||.|:..:..:||..
pombe   909 YKNIAYARFDGASSEMERQSAIDSFNAPNSELSCFLLSTRAGGVGINLASADTVIILDPDFNPHQ 973

Human   811 LIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLAEAGLSETNFSEMTESTDYLYK 875
            .:||..|.||.||...|.:..|..:.:.::   .:||...|.|....|       :.||.|..:.
pombe   974 DMQAIARAHRYGQKKKVLVFVLTTRDSVEE---KIIQNAQKKLVLDHL-------IVESLDQNHN 1028

Human   876 DPKQQKIYDL-------FQKSFEKEGSD---------MELLEAAESFDPGSASGTSGSSSQNMGD 924
            ..|     ||       .:..||:.|.:         :|||.               |.::...|
pombe  1029 SEK-----DLESILRHGARALFEEAGDEPSIKYNEYSVELLI---------------SEAEKQED 1073

Human   925 T-LDESSLTASPQKKRRFEFFDNWDS 949
            | .|||.:     |..:|.||..||:
pombe  1074 TSTDESDI-----KSNKFGFFRVWDN 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238
		HARP	248..302	CDD:462166
		HARP	343..397	CDD:462166	9/38 (24%)
		HepA	<423..856	CDD:440319	133/499 (27%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	74/233 (32%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		8/16 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934		6/30 (20%)
mit1	NP_595385.1	PHD	214..268	CDD:214584
		CD_CSD	359..426	CDD:475127
		PLN03142	546..>1086	CDD:215601	152/595 (26%)
		zf-CCCH_7	1235..1329	CDD:376012
		zf-CCCH_6	1331..1383	CDD:436598