Protein Alignment SMARCAL1 and rrp2

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_596602.1
• Gene: rrp2 / 2540464
• PomBaseID: SPBC23E6.02
• Length: 1040
• Species: Schizosaccharomyces pombe
• Alignment Length: 1136
• Identity: 211/1136 - (18%)
• Similarity: 374/1136 - (32%)
• Gaps: 424/1136 - (37%)

Human    55 QNFPRESCKPV----SHGVIFKQQN---LSSSSNADQ---RPHDSHSFQAKGIWKKPEEMPTACP 109
            :.|....|:.:    .|.:.|.:.|   .|||:::||   ...:.|..:.:..:...::......
pombe     8 EQFTLNPCEQIPLDDKHNIGFNKNNTPDYSSSASSDQLLKNDINRHEMERRIAFLNRKQALFNAF 72

Human   110 GHSPRSQM--------ALTGISP----PLAQSPPEVPKQQLLSYELGQGHAQASPEIRFTPFANP 162
            .|...|.:        .:.|:.|    .:|..|.|......||.|...              :..
pombe    73 MHDSSSSLNTMESNIEKVNGLFPNDNSVIALKPNEEKLNSSLSVENND--------------STY 123

Human   163 THKPLAKPKSSQETPAHSSGQPPRDAKLEAKTAKASPSGQNI-SYIHSSSESVTP-RTEGRLQQK 225
            |...|..||...:.|           .:.|.|...  .|.:: :.|.||::.::| :::...:||
pombe   124 TDATLIAPKIGLDRP-----------NINAITIDV--DGHSLQNEISSSTDKLSPSQSDALFEQK 175

Human   226 SGSSVQKGVNSQKGKCVRNGDRFQVLIGYNAELIAVFKTLPSKNYDPDTKTWNFSMNDYSAL-MK 289
            ..|                       :.:|...:.|.....|.:.:..||:   |:||:..: ||
pombe   176 QDS-----------------------LFWNDNAVIVVSDSESDDNNVRTKS---SLNDHDKVNMK 214

Human   290 AAQSLPTVNLQPLEWAYGSSESPSTSSEGQAGLPSAPSLS------------------------- 329
            ..::        ||.|:.:|:.....      |||.|.||
pombe   215 EKRN--------LELAFMNSKRKKLE------LPSLPVLSTAGPSYTNSLALPPFHHHNNYKMFN 265

Human   330 ---------FVKGRCMLISRAYFEADISYSQDLIALFKQMD------SRRY-------------D 366
                     |::|:             ..|.:.|:|..:.|      ::||             |
pombe   266 TTHTLEDDKFLQGK-------------GTSNNPISLSDEEDNEINFQNKRYGSDSVILPGGLLHD 317

Human   367 VKT---------RKW---------SFLLEEHSKLIAKVRCLPQVQLDPLPTTLTLAFASQLKKTS 413
            .|.         .:|         .|.|.:.:.  .||:...|.||:.|...|.    .||
pombe   318 SKLPEPGKHLFHLQWYHDRFHNIEGFNLSDSNN--QKVQDDQQQQLEELFKDLD----EQL---- 372

Human   414 LSLTPDVPEADLSEVDPK-LVSNLMPFQRAGVNF------AIAKGGRLLLADDMGLGKTIQAICI 471
                  |.:..:.|..|. |:..||..|:.|:.:      :..|||  :||||||||||:||:.:
pombe   373 ------VNDPTIREGTPAGLIPTLMEHQKEGLMWLKRLEESSKKGG--ILADDMGLGKTVQALAL 429

Human   472 AAFYRKE----WPLLVVVPSSVRFTWEQAFL-RWLPSLSPDC-INVVVTGKDRLTAGLI------ 524
            ......|    ...|::.|.|:...|....| :..||..|.. |:...:.|.::...|:
pombe   430 LVTRPPESKSVKTTLIITPVSLLQQWHNEILTKIAPSHRPTVYIHHGSSKKHKIAEQLMSYDIVL 494

Human   525 ---NIVSFDLLSKL--EKQLK--TPFKV-------------VIIDESHFLKNSRTARCRAAMPVL 569
               |:::::..:|:  :|.::  .|.|.             ||:||:..:||..|...|... :|
pombe   495 TTYNVIAYEFKNKMAYDKSIEDNAPIKKFEHLPFFEAEWYRVILDEAQTIKNRNTLAARGCC-LL 558

Human   570 KVAKRVILLSGTPAMSRPAELYTQI--IAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGE 632
            :...| ..|||||..:...|.|:.|  :.:||  :..:.:|...:    .:|...:.:.|:.:..
pombe   559 ESTYR-WCLSGTPMQNGVEEFYSLIKFLRIKP--YSDWSSFSKDF----TIPLSSNINTSAPMKR 616

Human   633 LKLLLEEAVMLRRLKSDVLSQLP------------------------------------------ 655
            .:.|| :||:|||.|:..:...|
pombe   617 FRGLL-KAVLLRRTKNTKIDGKPILTLPPKTAVKSETDLSSSEMEFYNTLQSGAQIQMRKYLQEG 680

Human   656 ----------------------------------------AKQRKIV-VIAPGRIN-------AR 672
                                                    ||.|.|. .|.|..:|       .:
pombe   681 TITTHYGSLLVLLLRLRQACCHPWLIVAREAAVDDNDSFQAKNRAIYNQIYPEAVNRLKLIETLQ 745

Human   673 TRAALDAAAKEM-------------------TTKDKTKQQQKDAL------------------IL 700
            ....:|..|:.:                   :::|..||...:.:                  ..
pombe   746 CSLCMDVVAELLIIVPCGHFLCRECLTHVITSSEDMAKQTSNENISPKCSVCEEYIDTERLLSYA 810

Human   701 FFNR-----------------------------------------------TAEAKIPSVIEYIL 718
            .|.|                                               |...||...:..:.
pombe   811 LFRRYSGMAPIVDADNKLRTENISELLPKQYSNILENRQMGMKIFTDPKHWTTSTKIEKALNAVK 875

Human   719 DLL-ESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVL 782
            ::: :...:|.|:|:.....|:..|....::.::::...|..|:|||......|::.....|.::
pombe   876 EIIKKQPTDKILIFSQFVSFLELFTVPFRQEGIKYLMYTGGLSTAERNQALINFEVDPNVRVLLI 940

Human   783 SITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQ 847
            |:.|.|:||..:.|:.|:..:.||||.:..||.||.|||||...|.|..:|...|.::.:..| |
pombe   941 SLKAGNVGLNLTCANHVIILDPFWNPYIEEQAVDRAHRIGQDKPVNILRIVTNNTIEERVLAL-Q 1004

Human   848 EKIKVLAEAGLSETNFSEM----TESTDYLY 874
            ::.:.|.::.|.|....|:    |:...:|:
pombe  1005 DRKRELIDSALGEKGLREISRLNTKELSFLF 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238		36/206 (17%)
		HARP	248..302	CDD:462166	10/54 (19%)
		HARP	343..397	CDD:462166	16/90 (18%)
		HepA	<423..856	CDD:440319	127/648 (20%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	64/248 (26%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		7/98 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934
rrp2	NP_596602.1	HepA	<380..1016	CDD:440319	127/647 (20%)
		RING_Ubox	742..812	CDD:473075	5/69 (7%)