DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMARCAL1 and snf22

DIOPT Version :9

Sequence 1:	NP_001120679.1	Gene:	SMARCAL1 / 50485	HGNCID:	11102	Length:	954	Species:	Homo sapiens
Sequence 2:	NP_588472.2	Gene:	snf22 / 2538881	PomBaseID:	SPCC1620.14c	Length:	1680	Species:	Schizosaccharomyces pombe

Alignment Length:	1366	Identity:	280/1366 - (20%)
Similarity:	458/1366 - (33%)	Gaps:	506/1366 - (37%)

- Green bases have known domain annotations that are detailed below.

Human    27 KLLAEQ--HQRTSSGT-----SIAGNPFQAKQGPSQN--FPRESCKPVSHGVIFKQ---QNLSSS 79
            |:.|.|  .|.||:.|     .:|.   ..|.|...|  ||..:..|.::......   .:.:|.
pombe   170 KVYANQLSQQNTSNPTYHNAYDMAS---MMKNGSRMNNSFPPTTPYPPANDTTVNSSLPHSFASP 231

Human    80 SNADQRPH-------------DSHSFQAKGIWKKPE----EMPTACPGHSPRSQMALTGISPP-- 125
            |:..::||             .||||.|:.|   |.    :......|..|.:....:..|||
pombe   232 SSTFEQPHTVQSRAPSVDTTSSSHSFSARNI---PANVSMQQQMGRRGSIPVNPSTFSASSPPSG 293

Human   126 -LAQSPPEVPKQQLLSYELGQGHAQASPEIRFTPF---------ANPTHKPLAKP---------- 170
             :..||....:....|:...:..:.|:|.   |||         |..:|.|..:|
pombe   294 SMLASPYNGYQNDAASFAHSKLPSSANPN---TPFNSTATVDVGAAGSHFPYPQPSNLDAINAKT 355

Human   171 --KSSQETPA---HSSGQPP----------RDAKLEAKTAKA---------SPSGQNI-SYIHSS 210
              :||..:||   :.:..||          |...::..|.|:         |||...: :..|..
pombe   356 YFQSSSNSPAPYVYRNNLPPSATSFQPSSSRSPSVDPNTVKSAQHIPRMSPSPSASALKTQSHVP 420

Human   211 SESVTPRTEGRLQQ----KSGSSVQKGVNSQKGK---CVRNGDRFQVLIG--YNA---------- 256
            |..|.|.::....|    ||.......:||..|:   .|:     |.:.|  |.|
pombe   421 SAKVPPTSKLNHAQLAMLKSQIVAYNCLNSPNGQVPPAVQ-----QAIFGRVYGASNEVSPSMPF 480

Human   257 -----ELIAVFKTLPSKNYDPDTKTW----------NFSMNDYSALMKAA-QSL--PTVNLQPLE 303
                 ::.:|.|..|::  |.:.:|.          .|....|||.:... :||  |:|:..||:
pombe   481 QQNVPQMSSVKKDTPTR--DANMRTSKAPYIQNIPNQFQRRAYSATIPVKNESLAKPSVSPMPLQ 543

Human   304 WAYGSSE-----------------------------SPSTSSEGQAGLPS--APSLSF------- 330
            .:.|.:|                             |..:|||..:.:||  .||:|:
pombe   544 QSTGKTEVAKRAQFPTNVNYSSCVDPRTYVKTPIPFSKFSSSENLSLIPSLLPPSISWDDVFLSS 608

Human   331 -------------------------------------VKGRCMLI------SRAYFEADISYSQD 352
                                                 ::.||:.:      .|....:.|.:|..
pombe   609 EIAIACSIANRIDFLEKENRPKSVNKKILQQDKSKSMIELRCLRLLEKQRSLRETINSVIPHSDS 673

Human   353 LIA-----LFKQMDSRRYDVKTRKWSFLLEEHSK------------------------LIAKV-- 386
            |.|     :|:.:  :|..::.......|.|..|                        ::.||
pombe   674 LAAGNLRLMFRNV--KRQTMQEANLVLALAEKQKTEHAMRQKEKLLTHLRSIMLHRKSIVTKVDK 736

Human   387 -------RC-------------------------LPQVQLDPLPTTLTLAFASQ-------LKKT 412
                   ||                         |..::.|.....|.|...::       ||:|
pombe   737 QNKAKTQRCKDIINFHAHLEKEEKKRIERSARQRLQALRADDEAAYLQLLDKAKDTRITHLLKQT 801

Human   413 SL---SLTPDVP---------------------EADLSEVD------------------PKLV-- 433
            ..   :||..|.                     ||.:||.|                  ||:.
pombe   802 DQYLENLTRAVRIQQSNIHSGNTSGKGSNSAELEAPISEEDKNLDYFKVAHRIHEEVEQPKIFVG 866

Human   434 SNLMPFQRAGVNFAIAKGGRLL---LADDMGLGKTIQAICIAAFY----RKEWPLLVVVPSSVRF 491
            ..|..:|..|:.:.::.....|   |||:||||||||.|....:.    .::.|.|::||.|...
pombe   867 GTLKDYQLKGLEWMLSLYNNNLNGILADEMGLGKTIQTIAFITYLIEKKNQQGPFLIIVPLSTLT 931

Human   492 TWEQAFLRWLPSL------SPDCINVVVTGKDRLTAGLINIVSFDLLSKLEKQLKTPFKVV--II 548
            .|...|.:|.||:      .|..:...:..:.|.:...:.:.:|:.:.| ::.|.:..|.|  ||
pombe   932 NWIMEFEKWAPSVKKIAYKGPPQLRKTLQSQIRSSNFNVLLTTFEYIIK-DRPLLSRIKWVHMII 995

Human   549 DESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYC 613
            ||.|.:||:: ::..:.:.....::..::|:|||..:...||:..:..|.|..|....:|.
pombe   996 DEGHRIKNTQ-SKLTSTLSTYYHSQYRLILTGTPLQNNLPELWALLNFVLPKIFNSIKSFD---- 1055

Human   614 DAKRMPWGWDYSGSSNLG---ELKLLLEEAVML-------------RRLKSDVLSQLPAKQRKIV 662
                   .|..:..:|.|   ::.|..|||:::             ||||.||..:||.|..|::
pombe  1056 -------EWFNTPFANTGGQDKIGLNEEEALLIIKRLHKVLRPFLFRRLKKDVEKELPDKVEKVI 1113

Human   663 VIAPGRINARTRAALDAAAKEMTTKDKTKQQQKDALILFF-------------NRTAEAK----I 710
            ......:..                 |..||.|...:||.             |...:.|    .
pombe  1114 KCPLSGLQL-----------------KLYQQMKKHGMLFVDGEKGKTGIKGLQNTVMQLKKICNH 1161

Human   711 PSVIEYI----------LDLLESGREKF---------LVFAHHKV--------VLDAITQELERK 748
            |.:.|.:          :|||.....||         |....||.        ::..:...|..|
pombe  1162 PFIFEDVERAIDPSGTNVDLLWRAAGKFELLDRILPKLFLTGHKTLMFFQMTQIMTIMEDYLRSK 1226

Human   749 HVQHIRIDGSTSSAEREDLCQQFQLSERHA-VAVLSITAANMGLTFSSADLVVFAELFWNPGVLI 812
            :.:::|:||||.|.:|..|..||...:... :.:||..|..:||...:||.|:..:..|||...:
pombe  1227 NWKYLRLDGSTKSDDRCSLLAQFNDPKSDVYIFMLSTRAGGLGLNLQTADTVIIFDTDWNPHQDL 1291

Human   813 QAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKI----KVLAEAG---------------- 857
            ||:||.||||||..|.|..|:.:.:.::.:....|.|:    ||: :||
pombe  1292 QAQDRAHRIGQTKEVRILRLITEKSIEENILSRAQYKLDLDGKVI-QAGKFDNKSTPEEREAFLR 1355

Human   858 -----------------LSETNFSEMTESTD---YLYKD-PKQQKIYDLFQKSFEKEGSDME-LL 900
                             |.:...:|:...||   .|:|. .|::...|::.|     |..:| ||
pombe  1356 SLLEHDGDDDHDLTYGELQDDELNELISRTDEELVLFKKLDKERAATDIYGK-----GKPLERLL 1415

Human   901 EAAE--SFDPGSASGTSGSSSQNMGD------------------------TLDESSLTASPQKKR 939
            ...|  .|........:..||..:.|                        |:|:.|.|..|:|:.
pombe  1416 TVNELPDFYKVEVDSFAVQSSSELEDQYLERKRRRRNSISYTELTLDELNTVDDPSSTLMPRKRG 1480

Human   940 R 940
            |
pombe  1481 R 1481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_001120679.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2	2..30		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..238		63/290 (22%)
		TMEM108	85..>303	CDD:318054	67/318 (21%)
		HARP	248..301	CDD:311403	17/82 (21%)
		HARP	343..396	CDD:311403	14/115 (12%)
		HepA	<417..889	CDD:223627	144/629 (23%)
		DESH box	549..552		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	904..934		9/55 (16%)
snf22	NP_588472.2	NHS	216..>396	CDD:291922	36/185 (19%)
		DUF4452	<229..292	CDD:291292	15/65 (23%)
		QLQ	428..463	CDD:214931	8/39 (21%)
		HepA	582..1345	CDD:223627	168/795 (21%)
		HSA	711..775	CDD:284861	5/63 (8%)
		DEXDc	889..1028	CDD:238005	38/140 (27%)
		Helicase_C	1187..1301	CDD:278689	34/113 (30%)
		COG5076	1395..1673	CDD:227408	19/92 (21%)
		SnAC	1398..1463	CDD:291293	11/69 (16%)
		Bromo_SNF2	1518..1620	CDD:99950
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910