Protein Alignment SMARCAL1 and smrc-1

DIOPT Version :10

• Sequence 1: NP_054859.2
• Gene: SMARCAL1 / 50485
• HGNCID: 11102
• Length: 954
• Species: Homo sapiens
• Sequence 2: NP_741192.1
• Gene: smrc-1 / 175907
• WormBaseID: WBGene00015806
• Length: 690
• Species: Caenorhabditis elegans
• Alignment Length: 637
• Identity: 232/637 - (36%)
• Similarity: 356/637 - (55%)
• Gaps: 54/637 - (8%)

Human   298 NLQPLEWAYGSSESPSTSSE--GQAGLPSAPSL----SFVKGRCMLISRAYFEADISYSQDLIAL 356
            |.||::....:|...||.:.  .|...|...||    ..||.:..:..|...|. ..:...:|.|
 Worm    63 NFQPMKPTMNNSTKQSTINNYIKQVQKPEPTSLIKPTIGVKLKLDIGDRIKIEF-YPFHSAVIDL 126

Human   357 FKQMDSRRYDVKTRKWSFLLEEHSKL--IAKVRCLPQVQLDPLPTTLTLAFASQLKKTSLSLT-- 417
            .||:.||.||...|.|:....:|..:  |.|.....:|:|:|||..:            :.||
 Worm   127 IKQVPSRNYDPAKRSWTVASSDHITISNILKNATAVKVELEPLPQNI------------IGLTNF 179

Human   418 -PDVPEADLSEV-DPKLVSNLMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQAICIAAFYRKEWP 480
             |....:||:.| ||.|:..|.|:|:.||.||:.:.||:||||:|||||::||:.||.:|:.:||
 Worm   180 KPKAAPSDLNTVMDPSLIERLFPYQKEGVIFALERDGRILLADEMGLGKSVQALTIARYYKADWP 244

Human   481 LLVVVPSSVRFTWEQAFLRWLPSLSPDCINVVVTGKDRL----TAGLINIVSFD-LLSKLEKQLK 540
            ||:|.|:||:..|::....:.|.:..  |.:|....|.|    |:..:.|:|:: ::.|.:...|
 Worm   245 LLIVCPASVKGAWKKQLNTFFPIIHR--IFIVDKSSDPLPDVCTSNTVAIMSYEQMVLKHDILKK 307

Human   541 TPFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQF 605
            ..::.:|.||||.||:.:..|.:.|..:.|||..|||||||||:|||:||:|||..:....|..|
 Worm   308 EKYRTIIFDESHMLKDGKARRTKVATDLSKVALHVILLSGTPALSRPSELFTQIRLIDHKLFTNF 372

Human   606 HAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQRKIVVIAPGRIN 670
            |.|.:||||.|:..:.::..|.:|..||..::.:.:|:||||:|||..||.|:|::|.::...|:
 Worm   373 HEFAIRYCDGKQGRFCFEAKGCTNSEELAAIMFKRLMIRRLKADVLKDLPEKRREVVYVSGPTID 437

Human   671 ARTRAALDAAAKEMTTKDKTKQQQK--DALILFFNRTAEAKIPSVIEYILD---LLESGREKFLV 730
            ||    :|...|.....:|....::  ::|:.|::.|...|..:|.|:||:   ..::...|.|:
 Worm   438 AR----MDDLQKARADYEKVNSMERKHESLLEFYSLTGIVKAAAVCEHILENYFYPDAPPRKVLI 498

Human   731 FAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMGLTFSS 795
            ||||::|||.|..|:.::.:..|||||.|.|..|..||..||..:...|||||||||.:|:|.::
 Worm   499 FAHHQIVLDTIQVEVNKRKLGSIRIDGKTPSHRRTALCDSFQTDDNIRVAVLSITAAGVGITLTA 563

Human   796 ADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKVLAEAGLSE 860
            |.:|||||:.:|||.|:|||||.||:||..||.:.||:||.||||.:|.::|:|:.||.:..||.
 Worm   564 ASVVVFAEIHFNPGYLVQAEDRAHRVGQKDSVFVQYLIAKKTADDVMWNMVQQKLDVLGQVSLSS 628

Human   861 TNFSEMTESTDYLYKDPKQQKIYDLFQKS------------FEKEGSDMELL 900
            ..| ...:.....:.|..|..|.:..:|:            .|||..|:|::
 Worm   629 DTF-RTADKMHLRFNDAAQPGIAEYLKKTPDTTIDEWEDPVEEKEDDDLEII 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMARCAL1	NP_054859.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Mediates interaction with RPA2. /evidence=ECO:0000269|PubMed:24910198	5..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..238
		HARP	248..302	CDD:462166	2/3 (67%)
		HARP	343..397	CDD:462166	16/55 (29%)
		HepA	<423..856	CDD:440319	185/443 (42%)
		DEXHc_HARP_SMARCAL1	436..645	CDD:350768	85/213 (40%)
		DESH box	549..552		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18805831	644..661		11/16 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..934
smrc-1	NP_741192.1	HARP	118..169	CDD:462166	15/50 (30%)
		DEXHc_HARP_SMARCAL1	200..412	CDD:350768	85/213 (40%)
		SF2_C_SNF	474..601	CDD:350180	61/126 (48%)