Protein Alignment PAFAH1B1 and Lis-1

DIOPT Version :10

• Sequence 1: XP_011522203.1
• Gene: PAFAH1B1 / 5048
• HGNCID: 8574
• Length: 428
• Species: Homo sapiens
• Sequence 2: NP_477160.1
• Gene: Lis-1 / 36791
• FlyBaseID: FBgn0015754
• Length: 411
• Species: Drosophila melanogaster
• Alignment Length: 429
• Identity: 288/429 - (67%)
• Similarity: 359/429 - (83%)
• Gaps: 21/429 - (4%)

Human     1 MVLSQRQRDELDWFQRGEDSILNKADEARNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKY 65
            ||||||||:||                  |:||||||.||||.::...|:|||  |::.|::||:
  Fly     3 MVLSQRQREEL------------------NQAIADYLGSNGYADSLETFRKEA--DLSTEVEKKF 47

Human    66 AGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVT 130
            .|||||||||||||||||||||:||.||::|...|.|...||.|.|||||||||::|:|||:.:|
  Fly    48 GGLLEKKWTSVIRLQKKVMELEAKLTEAEKEVIEGAPTKNKRTPGEWIPRPPEKFSLTGHRASIT 112

Human   131 RVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW 195
            ||||||:|::||||||||||::||:|||::||:||||||||||::||..||||||||||::||||
  Fly   113 RVIFHPIFALMVSASEDATIRIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLW 177

Human   196 DF-QGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVR 259
            || |.:|||:|||||||||||||.:|.||:::|||||:|||||||.|||||||:|||||||||||
  Fly   178 DFQQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVR 242

Human   260 PNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGK 324
            .:.:|::.|:||||||:|||:..:|:||.|||:|||.||||:||||::.|:|:||.|::.||...
  Fly   243 VHIEGSIFATCSNDQTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHH 307

Human   325 PGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKR 389
            .||||.||||||||::||||.|:||:||.||||||||:.||.|||:::|.:||||:||||.:|||
  Fly   308 QGPFLASGSRDKTIRIWDVSVGLCLLTLSGHDNWVRGLAFHPGGKYLVSASDDKTIRVWDLRNKR 372

Human   390 CMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 428
            |||||.||:||.||:||||..|||::|||||||||||||
  Fly   373 CMKTLYAHQHFCTSIDFHKAHPYVISGSVDQTVKVWECR 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAFAH1B1	XP_011522203.1	LisH	30..52	CDD:462501	12/21 (57%)
		WD40	122..426	CDD:238121	215/304 (71%)
		WD40 repeat	129..166	CDD:293791	26/36 (72%)
		WD40 repeat	172..208	CDD:293791	26/36 (72%)
		WD40 repeat	213..249	CDD:293791	27/35 (77%)
		WD40 repeat	256..291	CDD:293791	19/34 (56%)
		WD40 repeat	297..353	CDD:293791	35/55 (64%)
		WD40 repeat	359..395	CDD:293791	24/35 (69%)
		WD40 repeat	401..425	CDD:293791	17/23 (74%)
Lis-1	NP_477160.1	LisH	9..40	CDD:128913	20/50 (40%)
		WD40	100..409	CDD:238121	217/308 (70%)
		WD40 repeat	111..148	CDD:293791	26/36 (72%)
		WD40 repeat	154..191	CDD:293791	26/36 (72%)
		WD40 repeat	196..232	CDD:293791	27/35 (77%)
		WD40 repeat	239..274	CDD:293791	19/34 (56%)
		WD40 repeat	280..336	CDD:293791	35/55 (64%)
		WD40 repeat	342..378	CDD:293791	24/35 (69%)
		WD40 repeat	384..408	CDD:293791	17/23 (74%)