Protein Alignment PCSK6 and Fur1

DIOPT Version :10

• Sequence 1: NP_002561.1
• Gene: PCSK6 / 5046
• HGNCID: 8569
• Length: 969
• Species: Homo sapiens
• Sequence 2: NP_001262954.1
• Gene: Fur1 / 47220
• FlyBaseID: FBgn0004509
• Length: 1478
• Species: Drosophila melanogaster
• Alignment Length: 731
• Identity: 332/731 - (45%)
• Similarity: 418/731 - (57%)
• Gaps: 111/731 - (15%)

Human     3 PRAPP--APGPRPPPRAAAATD----------------TAAGA-----GGAGGAGGAGGPGFRPL 44
            |.:||  |..|.|||.:|...|                |...|     .|..|..|:.|.....:
  Fly   163 PSSPPTVAVPPPPPPSSALKVDPNGQSPVLPPYVLDYETGGKAKLTPNNGKFGQSGSSGSNNNHI 227

Human    45 APRPWRWLLLLALPAACSAPPPRPVYTNHWAVQVLGGP-AEADRVAAAHGYLNLGQIGNLEDYYH 108
            ...                      ||:.|||.:..|. ..||.||..||::|||:|  .:|:||
  Fly   228 VGH----------------------YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYH 268

Human   109 FYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQ-VRSDP-----------QALYFN 161
            |.|.|..|||...:....|.|..|.:|.|.:||..|.|.||. :|..|           .|:.||
  Fly   269 FAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFN 333

Human   162 DPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYD 226
            |..|..||||:.|.     ..:|||..|||.|.|||.|||||||||:|.:|||:..|||..||||
  Fly   334 DSKWPQMWYLNRGG-----GLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYD 393

Human   227 VNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKS 291
            ||.:|.||.|.||.::.|:|||||||||||:||||:|.|||||.|.:||:|||||||||.|||:|
  Fly   394 VNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARS 458

Human   292 LGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCS 356
            |.:.|.:|||||||||||||||||||||.||.:||..|..|||.|.||||:|||||||||.|.|:
  Fly   459 LSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCN 523

Human   357 CDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSV 421
            ||||||||:|:|:|||||.|:.|||.|:|:||||||||||...|:::|||||...||..|||||.
  Fly   524 CDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSA 588

Human   422 SAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEAL 486
            |||:.|||.||.|::|..|||||:||::|:|::||:||...|..||.|.:|||.:|:||:||..:
  Fly   589 SAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEM 653

Human   487 VVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVRTSISHP 551
            |..|:.|.|||.|..|...:....:.||     ..|.:|.....:..:.|.|||||..:.:::..
  Fly   654 VRVARNWKAVPEQQRCEINAPHVDKVIP-----PRTHITLQLTVNHCRSVNYLEHVQAKITLTSQ 713

Human   552 RRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNP 616
            ||||:|::|.||:.|...||..|:.|.|..||..|.||:||.|||..:|.|.|||.:
  Fly   714 RRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHN-------- 770

Human   617 EKQGK------LKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDE 675
              :|:      |:|||||.|||.:                     .:.|.    .|..|..|...
  Fly   771 --EGRYMGHALLREWSLIFYGTTQ---------------------SIGPN----DPISVPKPSGS 808

Human   676 EDYTAQSTPGSANILQ 691
            |..|..|:..::|:.|
  Fly   809 EATTPNSSSTTSNLHQ 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PCSK6	NP_002561.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		15/58 (26%)
		S8_pro-domain	73..149	CDD:465126	32/76 (42%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	160..454	CDD:173789	195/293 (67%)
		P_proprotein	539..629	CDD:460225	39/95 (41%)
		Cell attachment site. /evidence=ECO:0000255	553..555		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..683		6/24 (25%)
		FU 1	692..739		332/731 (45%)
		GF_recep_IV	694..804	CDD:464344
		CRM (Cys-rich motif)	695..930
		FU	799..845	CDD:238021
		FU	844..886	CDD:214589
		FU 5	895..943
		FU	896..930	CDD:214589
		PLAC	942..965	CDD:462560
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:465126	32/76 (42%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	332..621	CDD:173789	195/293 (67%)
		P_proprotein	701..787	CDD:460225	39/95 (41%)
		FU	1320..>1350	CDD:214589