Protein Alignment PCSK6 and S1P

DIOPT Version :10

• Sequence 1: NP_002561.1
• Gene: PCSK6 / 5046
• HGNCID: 8569
• Length: 969
• Species: Homo sapiens
• Sequence 2: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Alignment Length: 742
• Identity: 156/742 - (21%)
• Similarity: 253/742 - (34%)
• Gaps: 233/742 - (31%)

Human    68 PVYTNHWAVQVLGG-----------------PAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTF 115
            ||..::.|.::||.                 |::.|.:....||         |....|...:
  Fly    39 PVRESYIAAKLLGSNVTNWRIVPRLNLAWQYPSDFDILRVCDGY---------ESSSEFIIER-- 92

Human   116 KRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLH-------- 172
                         |:..|.||.:..|...||:            .|...:||:.|:|
  Fly    93 -------------LQTHPSVKAVVPQRSVRRI------------LNYDAYSNLTYIHRHPQGVLR 132

Human   173 ----CGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDL-----APNYDSYASYDVN 228
                ..|::.:..|.::....||.|.|||.|.|.|.|.|:.:|||..     ..|:.:..|.|
  Fly   133 NRNPNNDRHRQLCSVLHANILWKLGITGKGVKVAIFDTGLTKNHPHFRNVKERTNWTNEKSLD-- 195

Human   229 GNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTD----VVEA 289
                         :...|||..||.:|:|..   |: |.|.:|.:...::.......    .::|
  Fly   196 -------------DRVSHGTFVAGVIASSRE---CL-GFAPDADLYIFKVFTNSQVSYTSWFLDA 243

Human   290 KSLGIRPNYIDIYSAS-WGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGG---- 349
            .:..|. ..|:|.:.| .|||    .:|.|  ..::..|....      ..|.:.|:||.|
  Fly   244 FNYAIY-RKINILNLSIGGPD----FMDSP--FVEKVLELSAN------NVIMISAAGNDGPLYG 295

Human   350 ---REGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLA---TTYSSGAFYERKIVTTDL 408
               ..||.....|.....:...::..:..|...|.|......:.   .||.|      ::..:|:
  Fly   296 TLNNPGDQSDVVGVGGIQFDDKIAKFSSRGMTTWELPLGYGRMGLDIVTYGS------QVEGSDV 354

Human   409 RQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVS 473
            |:.|. ..:|||||:|:|||..||.:..    .::.:.::     .||.||  ...:.|| .|:.
  Fly   355 RKGCR-RLSGTSVSSPVVAGAAALLISG----AFQKIDYI-----NPASLK--QVLIEGA-EKLP 406

Human   474 HFYGF-------GLVDAEALVVEAK-KWTAVP--------------SQHMCVAASDKRPRSIPLV 516
            |:..|       .|:.:..|::..| |.|.:|              ||.:...:|    .:|..|
  Fly   407 HYNMFEQGAGKLNLLKSMQLLLSYKPKITLIPAYLDFTQNYMWPYSSQPLYYGSS----VAIANV 467

Human   517 QVLRTTALTSACA---------EHSDQRVVYLEHVVVRTSISHPRRGDLQIYL-VSPSGTKSQLL 571
            .:|...::||...         |:..|   :|:.....:.|..|..|.:.::: |...|...:.:
  Fly   468 TILNGISVTSHIVGIPKWIPDFENQGQ---FLQVSAQVSPIVWPWTGWMSVFIAVKKEGENFEGV 529

Human   572 AKRLLDLSNEGF---TNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRN------------------ 615
            .|..:.|..|.|   ||...:|        |..:.|.|:..|...||
  Fly   530 CKGSITLVLESFKQTTNETHVT--------EVDFPLTIKVTPKPPRNKRILWDQYHSLRYPPRYI 586

Human   616 PEKQGKLK----EWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAALSPSQ-----VEV 671
            |....|:|    :|      .|:|.:..|....:..|.:......|..|....:.|.     :..
  Fly   587 PRDDLKVKLDPLDW------RADHIHTNFRDMYTHLRNVGYYIDVLREPFTCFNASDYGALLIVD 645

Human   672 PE----DEEDYTAQSTPGSANILQTSV 694
            ||    |||          .|.||.:|
  Fly   646 PERGFGDEE----------INALQENV 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PCSK6	NP_002561.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39
		S8_pro-domain	73..149	CDD:465126	16/92 (17%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	160..454	CDD:173789	74/325 (23%)
		P_proprotein	539..629	CDD:460225	23/115 (20%)
		Cell attachment site. /evidence=ECO:0000255	553..555		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..683		7/33 (21%)
		FU 1	692..739		1/3 (33%)
		GF_recep_IV	694..804	CDD:464344	1/1 (100%)
		CRM (Cys-rich motif)	695..930		156/742 (21%)
		FU	799..845	CDD:238021
		FU	844..886	CDD:214589
		FU 5	895..943
		FU	896..930	CDD:214589
		PLAC	942..965	CDD:462560
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	74/303 (24%)
		DUF4350	610..754	CDD:464118	13/63 (21%)