DRSC/TRiP Functional Genomics Resources

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Protein Alignment PCSK6 and TppII

DIOPT Version :10

Sequence 1:NP_002561.1 Gene:PCSK6 / 5046 HGNCID:8569 Length:969 Species:Homo sapiens
Sequence 2:NP_725252.1 Gene:TppII / 36444 FlyBaseID:FBgn0020370 Length:1441 Species:Drosophila melanogaster


Alignment Length:656 Identity:120/656 - (18%)
Similarity:198/656 - (30%) Gaps:247/656 - (37%)


- Green bases have known domain annotations that are detailed below.


Human   218 NYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDG- 281
            |.|.:.|..||.:| :.:........:.|||. ...:|:..::|..:.|:|.||||..:.:.|| 
  Fly   332 NVDDFLSISVNVHD-EGNVLEVVGMSSPHGTH-VSSIASGNHSSRDVDGVAPNAKIVSMTIGDGR 394

Human   282 ------------DVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAF-EYGIKKG 333
                        .:|.|:|....|.|   ||:.:.|:|...:.......|.|..:.. :||:   
  Fly   395 LGSMETGTALVRAMTKVMELCRDGRR---IDVINMSYGEHANWSNSGRIGELMNEVVNKYGV--- 453

Human   334 RQGLGSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENG--YKPWYLEECASTLATTYSSG 396
                    ||.:..|......|:    ..:...||..|....|  ..|..:|       ..|:..
  Fly   454 --------VWVASAGNHGPALCT----VGTPPDISQPSLIGVGAYVSPQMME-------AEYAMR 499

Human   397 AFYERKIVTTDLRQRCTDG--------------------------HTGTSVSAPMVAGIIALALE 435
            ......:.|...|..|.||                          ..|||::||.|||.:||.: 
  Fly   500 EKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQFTMSKSQLMNGTSMAAPHVAGAVALLI- 563

Human   436 ANSQLTWRDVQHLLVKTSRPAHLKAS-----DWKVNGAG---------HKVSH------------ 474
              |.|..:::::......|...:.|:     |....|.|         |...|            
  Fly   564 --SGLKQQNIEYSPYSIKRAISVTATKLGYVDPFAQGHGLLNVEKAFEHLTEHRQSKDNMLRFSV 626

Human   475 ------------------------------FYGFGLVDAEA------------LVVEAKKWT--- 494
                                          ||.    |.||            .::.::.|.   
  Fly   627 RVGNNADKGIHLRQGVQRNSIDYNVYIEPIFYN----DKEADPKDKFNFNVRLNLIASQPWVQCG 687

Human   495 ------------AV--------PSQHM---------CVAASDKRPRSIPLVQ--VL---RTTALT 525
                        ||        |..|.         ||.........:.:||  ||   :.|.:.
  Fly   688 AFLDLSYGTRSIAVRVDPTGLQPGVHSAVIRAYDTDCVQKGSLFEIPVTVVQPHVLESDQNTPVF 752

Human   526 SACAEHSDQRVVYLEHVVVRTSISHPRR---GDLQIYLVSPSGTK---------SQLLAKRLLDL 578
            ...:...|..|.:..:.:.|..|..|.|   .:|::.:..|:..:         :|||.|     
  Fly   753 EPASSKGDNSVEFQPNTIQRDFILVPERATWAELRMRITDPNRGEDIGKFFVHTNQLLPK----- 812

Human   579 SNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKE----------------WSL 627
              :.....|.|.:...|.:.|.....::           |.|::.|                :||
  Fly   813 --QSCRKLETMKIVSVGSENESIMAFKV-----------KSGRILELCIAKYWSNYGQSHLKYSL 864

Human   628 ILYGTAEHPYHTFSAHQSRS-RMLELSA-------PELE---------PPKAALSP---SQVEVP 672
            ...|...|..:.:..|..|. ..||:.|       |:|:         |.:|.:||   ::..:|
  Fly   865 RFRGVEAHNPNAYVMHAGRGIHKLEIEALVAEDVQPQLQLKNAEVVLKPTEAKISPLSATRDVIP 929

Human   673 EDEEDY 678
            :..:.|
  Fly   930 DGRQVY 935

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PCSK6NP_002561.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
S8_pro-domain 73..149 CDD:465126
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 160..454 CDD:173789 60/277 (22%)
P_proprotein 539..629 CDD:460225 19/117 (16%)
Cell attachment site. /evidence=ECO:0000255 553..555 1/4 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..683 6/33 (18%)
FU 1 692..739
GF_recep_IV 694..804 CDD:464344
CRM (Cys-rich motif) 695..930
FU 799..845 CDD:238021
FU 844..886 CDD:214589
FU 5 895..943
FU 896..930 CDD:214589
PLAC 942..965 CDD:462560
TppIINP_725252.1 Peptidases_S8_Tripeptidyl_Aminopeptidase_II 101..589 CDD:173796 62/286 (22%)
TPPII 892..1077 CDD:463636 9/44 (20%)
TPPII_N 1144..1257 CDD:403697
Blue background indicates that the domain is not in the aligned region.

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