DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PABPC3 and pabpc1a

DIOPT Version :9

Sequence 1:	NP_112241.2	Gene:	PABPC3 / 5042	HGNCID:	8556	Length:	631	Species:	Homo sapiens
Sequence 2:	NP_001026846.1	Gene:	pabpc1a / 606498	ZFINID:	ZDB-GENE-030131-3238	Length:	634	Species:	Danio rerio

Alignment Length:	639	Identity:	525/639 - (82%)
Similarity:	568/639 - (88%)	Gaps:	13/639 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDA 65
            ||||.||||.|||||||||||||||||||||||||||||||:|||::|..|..|||||||...||
Zfish     1 MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMMTRRSLGYAYVNFQQPADA 65

Human    66 EHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNV 130
            |.||||||||||||:||||||||||||||||||||||:|||||||:|||||||.|||||||||.|
Zfish    66 ERALDTMNFDVIKGRPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKV 130

Human   131 VCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYI 195
            |||||||||||||||||||||||||:||||||||.||||||:||||||||||:|||||||.||||
Zfish   131 VCDENGSKGYGFVHFETHEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAEMGARAKEFTNVYI 195

Human   196 KNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQ 260
            ||||||||||:||::|.|:|||||::||||:|||||||||||||||||||:|||||||||:||||
Zfish   196 KNFGEDMDDEKLKEIFCKYGPALSIRVMTDDSGKSKGFGFVSFERHEDAQRAVDEMNGKEMNGKQ 260

Human   261 IYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERLRKAFSPFGTITSAKV 325
            :||||||||.||||||||.||||||||:||||.|||||||||||:|||||||.||||||||||||
Zfish   261 VYVGRAQKKGERQTELKRKFEQMKQDRMTRYQGVNLYVKNLDDGLDDERLRKEFSPFGTITSAKV 325

Human   326 MMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAYLTNEYMQRMASVR 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||:||::|||||||||
Zfish   326 MMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTSQYMQRMASVR 390

Human   391 AVPN------QRAPPSGYFMTAVPQTQNHAAYYPPSQIARLRPSPRWTAQGARPHPFQNKP-SAI 448
            ||||      |.||||||||.|:||.||.|||||.||:|:|||||||..||.||..|||.| :|:
Zfish   391 AVPNPVLNPYQPAPPSGYFMAAIPQAQNRAAYYPTSQLAQLRPSPRWATQGVRPQHFQNMPNAAV 455

Human   449 RPGAPR-VPFSTMRPASSQVPRVMSTQRVANTSTQTVGPRPAAAAAAAATPAVRTVPRYKYAAGV 512
            ||.||| ..|:.:||| |||||:|::||:   .:|.:|||||||.||.....||.||:||||.||
Zfish   456 RPSAPRPQTFNPVRPA-SQVPRMMTSQRM---GSQAMGPRPAAAGAATGPAQVRGVPQYKYAPGV 516

Human   513 RNPQQHRNAQPQVTMQQLAVHVQGQETLTASRLASAPPQKQKQMLGERLFPLIQAMHPTLAGKIT 577
            |||||....||||.|||.||||||||.||||.||:||||:||||||||||||||.|||:||||||
Zfish   517 RNPQQRMPTQPQVPMQQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQNMHPSLAGKIT 581

Human   578 GMLLEIDNSELLYMLESPESLRSKVDEAVAVLQAHQAKEATQKAVNSATGVPTV 631
            ||||||||||||:|||||||||||||||||||||||||||.||:|.| ..||.|
Zfish   582 GMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKSVPS-PAVPAV 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PABPC3	NP_112241.2	PABP-1234	11..610	CDD:130689	501/606 (83%)
pabpc1a	NP_001026846.1	PABP-1234	11..614	CDD:130689	501/606 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	311	1.000	Domainoid score	I7093
eggNOG	1	0.900	-	-		E1_KOG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H118007
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53624
OrthoDB	1	1.010	-	-		D1027234at2759
OrthoFinder	1	1.000	-	-		FOG0000294
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100425
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X269
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.790