Protein Alignment PABPC3 and shep

DIOPT Version :10

• Sequence 1: NP_112241.2
• Gene: PABPC3 / 5042
• HGNCID: 8556
• Length: 631
• Species: Homo sapiens
• Sequence 2: NP_001246636.1
• Gene: shep / 38605
• FlyBaseID: FBgn0052423
• Length: 590
• Species: Drosophila melanogaster
• Alignment Length: 428
• Identity: 93/428 - (21%)
• Similarity: 159/428 - (37%)
• Gaps: 124/428 - (28%)

Human   100 NIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETHEAAERAIKKMNGML 162
            |::::.|.:...:|.|.:..:.:|.|:|...:.|:  |..||||||.||....||.|:|.:.|
  Fly   244 NLYIRGLQQGTTDKDLVNMCAQYGTIISTKAILDKTTNKCKGYGFVDFEQPAFAECAVKGLQG-- 306

Human   163 LNGRKVFVGQFKSRKEREAELGARAKEFP-NVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDE 226
                          |..:|::..:.::.| |:||.|......:..|:.:..|:|..:|.:::.|:
  Fly   307 --------------KGVQAQMAKQQEQDPTNLYIANLPPHFKETDLEAMLSKYGQVVSTRILRDQ 357

Human   227 SGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQ--IYV----GRAQKKVERQTELKRTFEQMKQ 285
            ...|||.||...|..|..::.:...||..:.|.:  :.|    |..:||
  Fly   358 QMNSKGVGFARMESREKCEQIIQMFNGNTIPGAKDPLLVKFADGGPKKK---------------- 406

Human   286 DRITRYQVVNLYVKNLDDG------IDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPE 344
                     ||: |..|..      :..|.:..|:.|  |:....|.:..|...|..:..||:|
  Fly   407 ---------NLF-KTPDPNARAWRDVSAEGIPVAYDP--TMQQNGVSVNVGTPIGVPYSRFSAP- 458

Human   345 EATKAVTEMNGRIVATKPLYVALAQRKEERQAYLTNEYMQRMASVRAVPNQRAPPSGYFMTAVPQ 409
                   ::.|..||...........:.:.|...:.:|||..|         |||.|
  Fly   459 -------QVGGYPVAGSQWIPGYMMTQVDDQTSYSPQYMQMAA---------APPLG-------- 499

Human   410 TQNHAAYYPPSQIARLRPSPRWTAQGARPHPFQNKPSAIRPGAPRVPFSTMRPASSQVPRVMSTQ 474
                ...|.|..:.:::|      :|.         |.:..|...||:.||.|.       ::|.
  Fly   500 ----VTSYKPEAVNQVQP------RGI---------SMMVSGDTGVPYGTMMPQ-------LATL 538

Human   475 RVAN--------------TSTQTVGPRPAAAAAAAATP 498
            ::.|              |...|:....:..|:.||:|
  Fly   539 QIGNSYISPTYPYYAPPPTIIPTMPMTDSEQASTAASP 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PABPC3	NP_112241.2	PABP-1234	11..610	CDD:130689	93/428 (22%)
shep	NP_001246636.1	RRM_SF	240..321	CDD:473069	24/92 (26%)
		RRM2_MSSP	322..400	CDD:409690	20/77 (26%)