Protein Alignment schlank and CERS4

DIOPT Version :10

• Sequence 1: NP_652526.1
• Gene: schlank / 50392
• FlyBaseID: FBgn0040918
• Length: 400
• Species: Drosophila melanogaster
• Sequence 2: XP_047295389.1
• Gene: CERS4 / 79603
• HGNCID: 23747
• Length: 464
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 151/399 - (37%)
• Similarity: 234/399 - (58%)
• Gaps: 22/399 - (5%)

  Fly     3 ILNEFSNVFWSTHIWLPPNTTWADIAPGSRPDVVHANYKDLIWPIPFAAVVMLVRYTLERFWISP 67
            :|:.|:..||....|||||.||.::.  .|...|:.:.:||:..:|.|.|::.:|...|||...|
Human    71 MLSSFNEWFWQDRFWLPPNVTWTELE--DRDGRVYPHPQDLLAALPLALVLLAMRLAFERFIGLP 133

  Fly    68 VGKSLGIRSSRPKKAANVPILEKTY-AKSTRLDKKKLVPLSKQTDMSEREIERWWRLRRAQDKPS 131
            :.:.||:|....::......|||.: .:..|..:.:|..|:.|..::.::.:||:|.||.||:|.
Human   134 LSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQ 198

  Fly   132 TLVKFCENTWRCIYYLYSFIFGVIVLWDKPWFWDVKSCWYGYPHQSISNDIWWYYMISMSFYWSL 196
            ...||||.:||.::||.||:.|:.||:.:.|.|....||..||:|::...::|:|::.:.||.||
Human   199 LTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSL 263

  Fly   197 TGTQFFDVKRKDFWQMFIHHMVTLLLMSLSWVCNLHRVGSLVLVVHDCADIFLEAAKLTKYAKYQ 261
            .....||||||||.:..|||.|.::||:.|:..||.|:|||||::||.:|..|||.|:..|.:||
Human   264 LIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDSSDYLLEACKMVNYMQYQ 328

  Fly   262 KLCDAIFAIFTVVWIVTRLGFYP-RIIYSSSVEAPRILPMFPAYYIFNSLLLMLLVLHVIWTYMI 325
            ::|||:|.||:.|:..|||..:| :|:|::..|:......|..||.||.||::|.:|||.|:.:|
Human   329 QVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYFFNGLLMLLQLLHVFWSCLI 393

  Fly   326 LKIVVDSLQKGLMSGDIRSSDSEDLTDSSGNA-------RLTNGSARSKNKSISSAPSDKGSAGG 383
            |:::...::||.|..||||...|  :|||..|       :|.||:|....    .||:|     |
Human   394 LRMLYSFMKKGQMEKDIRSDVEE--SDSSEEAAAAQEPLQLKNGAAGGPR----PAPTD-----G 447

  Fly   384 AGSRAGARV 392
            ..||...|:
Human   448 PRSRVAGRL 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
schlank	NP_652526.1	homeodomain	75..131	CDD:238039	15/56 (27%)
		TLC	135..334	CDD:214789	87/199 (44%)
CERS4	XP_047295389.1	homeodomain	141..198	CDD:238039	15/56 (27%)
		TLC	201..402	CDD:214789	87/200 (44%)