DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment schlank and Cers2

DIOPT Version :9

Sequence 1:	NP_652526.1	Gene:	schlank / 50392	FlyBaseID:	FBgn0040918	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	NP_001307421.1	Gene:	Cers2 / 76893	MGIID:	1924143	Length:	380	Species:	Mus musculus

Alignment Length:	367	Identity:	138/367 - (37%)
Similarity:	212/367 - (57%)	Gaps:	6/367 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ILNEFSNVFWSTHIWLPPNTTWADIAPGSRPDVVHANYKDLIWPIPFAAVVMLVRYTLERFWISP 67
            :|....:.||...:|||.|.||||:.  .:...|:|...||...:|.|.:.:::||..|.:..:|
Mouse     1 MLQTLYDYFWWERLWLPVNLTWADLE--DKDGRVYAKASDLYITLPLALLFLVIRYFFELYVATP 63

  Fly    68 VGKSLGIRSSRPKKAANVPILEKTYAKSTRLDKKKLVP-LSKQTDMSEREIERWWRLRRAQDKPS 131
            :...|.::.....:|.....||..|..|.:..|:..|. ||:|:.:|.|::|||:|.||.||:||
Mouse    64 LAALLNVKEKTRLRAPPNATLEHFYQTSGKQPKQVEVDLLSRQSGLSGRQVERWFRRRRNQDRPS 128

  Fly   132 TLVKFCENTWRCIYYLYSFIFGVIVLWDKPWFWDVKSCWYGYPHQSISNDIWWYYMISMSFYWSL 196
            .|.||.|.:||..|||.:|:.|:.|..|||||:|::..|.|||.|||....:|||||.:||||||
Mouse   129 LLKKFREASWRFTYYLIAFVAGMAVTVDKPWFYDLRKVWEGYPIQSIIPSQYWYYMIELSFYWSL 193

  Fly   197 TGTQFFDVKRKDFWQMFIHHMVTLLLMSLSWVCNLHRVGSLVLVVHDCADIFLEAAKLTKYAKYQ 261
            ..:...|||||||.:..|||:.|::|:..||..|..|.|:|::.:||.:|..||:||:..||.::
Mouse   194 LFSIASDVKRKDFKEQIIHHVATIILLCFSWFANYVRAGTLIMALHDASDYLLESAKMFNYAGWK 258

  Fly   262 KLCDAIFAIFTVVWIVTRLGFYP-RIIYSSSVEAPRILPMFPAYYIFNSLLLMLLVLHVIWTYMI 325
            ..|:.:|.:|.:|:|:|||...| .|::.:.:....:.|.|..||.||.::.:|.:||:.|.|.|
Mouse   259 NTCNNLFIVFAIVFIITRLVIMPFWILHCTMIYPLELYPAFFGYYFFNFMMAVLQMLHIFWAYFI 323

  Fly   326 LKIVVDSLQKGLMSGDIRSSDSEDLTDSSGNARLTNGSARSK 367
            |::....:...|:..:  .||.|:...|.|........|:|:
Mouse   324 LRMAHKFITGKLIEDE--RSDREETESSEGEETAAGAGAKSR 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
schlank	NP_652526.1	homeodomain	75..131	CDD:238039	20/56 (36%)
schlank	NP_652526.1	TLC	135..334	CDD:214789	85/199 (43%)
Cers2	NP_001307421.1	Homeobox-like. /evidence=ECO:0000305	67..128		21/60 (35%)
		homeodomain	71..128	CDD:238039	20/56 (36%)
		TLC	131..332	CDD:214789	85/200 (43%)
		Last loop motif. /evidence=ECO:0000250\|UniProtKB:Q96G23	291..300		1/8 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..380		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849119
Domainoid	1	1.000	55	1.000	Domainoid score	I11053
eggNOG	1	0.900	-	-		E1_COG5058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D383274at33208
OrthoFinder	1	1.000	-	-		FOG0000327
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100372
Panther	1	1.100	-	-	O	PTHR12560
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R648
SonicParanoid	1	1.000	-	-		X237
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.740