DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment schlank and Cers5

DIOPT Version :9

Sequence 1:	NP_652526.1	Gene:	schlank / 50392	FlyBaseID:	FBgn0040918	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	NP_082291.1	Gene:	Cers5 / 71949	MGIID:	1919199	Length:	414	Species:	Mus musculus

Alignment Length:	381	Identity:	160/381 - (41%)
Similarity:	231/381 - (60%)	Gaps:	18/381 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 WSTHIWLPPNTTWADI-APGSRPDVVHANYKDLIWPIPFAAVVMLVRYTLERFWISPVGKSLGIR 75
            ||...|||.|.:|||: .||.......|.:  ::...|.|..:..||...|||...|....:||:
Mouse    17 WSESFWLPQNVSWADLEGPGDGYGYPRAQH--VLSVFPLAVCIFSVRMLFERFIAKPCALRVGIK 79

  Fly    76 SSRPKKAANVPILEKTYAKSTRL-DKKKLVPLSKQTDMSEREIERWWRLRRAQDKPSTLVKFCEN 139
            .|...|......|||.:...|:. |:|:|..||||.|.|.|:|:.|:|.||.||||.||.||||:
Mouse    80 DSPVNKVEPNDTLEKVFVSVTKYPDEKRLKGLSKQLDWSVRKIQCWFRHRRNQDKPPTLTKFCES 144

  Fly   140 TWRCIYYLYSFIFGVIVLWDKPWFWDVKSCWYGYPHQSISNDIWWYYMISMSFYWSLTGTQFFDV 204
            .||..|||..|.:|:..||..|||||.:.|||.||:|.:|.::::||:..::|||||..:||.||
Mouse   145 MWRFTYYLCIFCYGIRFLWSMPWFWDTRQCWYNYPYQPLSRELYYYYITQLAFYWSLMFSQFIDV 209

  Fly   205 KRKDFWQMFIHHMVTLLLMSLSWVCNLHRVGSLVLVVHDCADIFLEAAKLTKYAKYQKLCDAIFA 269
            |||||..||||||:.::|.:.|:|.|:.|||:|:..:||.||..|||||:..||:.::||..:|.
Mouse   210 KRKDFLMMFIHHMIGIMLTTFSYVNNMVRVGALIFCLHDFADPLLEAAKMANYARRERLCTTLFV 274

  Fly   270 IFTVVWIVTRLGFYPRIIYSSSV-EAPRILPMFPAYYIFNSLLLMLLVLHVIWTYMILKIVVDSL 333
            ||...:||:||..:|..|.:::: |:..|:..:|::::||:|||:|.|||.||:|:|::....:|
Mouse   275 IFGAAFIVSRLAIFPLWILNTTLFESWEIIGPYPSWWLFNALLLILQVLHAIWSYLIVQTASKAL 339

  Fly   334 QKGLMSGDIR-----SSDSEDLTDSSGNARLTNGSARSKNKSISSAPSDKGSAGGA 384
            .:|.:|.|.|     ||:.||.|....|   .:||:.|     :.|....|..||:
Mouse   340 SRGKVSKDDRSDVESSSEEEDETTHKNN---LSGSSSS-----NGANCMNGYMGGS 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
schlank	NP_652526.1	homeodomain	75..131	CDD:238039	24/56 (43%)
schlank	NP_652526.1	TLC	135..334	CDD:214789	93/199 (47%)
Cers5	NP_082291.1	Homeobox-like. /evidence=ECO:0000305	75..136		26/60 (43%)
		homeodomain	87..136	CDD:238039	22/48 (46%)
		TLC	139..340	CDD:214789	93/200 (47%)
		Last loop motif. /evidence=ECO:0000250\|UniProtKB:Q8N5B7	299..309		2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..373		10/28 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849117
Domainoid	1	1.000	218	1.000	Domainoid score	I2644
eggNOG	1	0.900	-	-		E1_COG5058
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23634
Inparanoid	1	1.050	315	1.000	Inparanoid score	I2539
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D383274at33208
OrthoFinder	1	1.000	-	-		FOG0000327
OrthoInspector	1	1.000	-	-		otm43825
orthoMCL	1	0.900	-	-		OOG6_100372
Panther	1	1.100	-	-	LDO	PTHR12560
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R648
SonicParanoid	1	1.000	-	-		X237
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.830