DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment schlank and Cers4

DIOPT Version :9

Sequence 1:	NP_652526.1	Gene:	schlank / 50392	FlyBaseID:	FBgn0040918	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	NP_080334.3	Gene:	Cers4 / 67260	MGIID:	1914510	Length:	393	Species:	Mus musculus

Alignment Length:	380	Identity:	143/380 - (37%)
Similarity:	227/380 - (59%)	Gaps:	8/380 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SNVFWSTHIWLPPNTTWADIAPGSRPDVVHANYKDLIWPIPFAAVVMLVRYTLERFWISPVGKSL 72
            |...|....|||||.|||::.  .|..:|.|:...::...|.|.|::.||...|||...|:.:.:
Mouse     6 SEWLWQETYWLPPNVTWAELE--DRDGLVFAHPHHVLAAFPVALVLVAVRIVFERFVALPLSRWM 68

  Fly    73 GIRSSRPKKAANVPILEKTYAKSTRL-DKKKLVPLSKQTDMSEREIERWWRLRRAQDKPSTLVKF 136
            |::....:|....|:|||.:.:..:. ::.::|.|:.|..::.|:.:||:|.||.||:||...||
Mouse    69 GVQDPIRRKIKPNPVLEKYFLRMKQCPEETQMVLLASQCGLTLRQTQRWFRRRRNQDRPSLSKKF 133

  Fly   137 CENTWRCIYYLYSFIFGVIVLWDKPWFWDVKSCWYGYPHQSISNDIWWYYMISMSFYWSLTGTQF 201
            ||..||.::||.||:.|..:|:.:.|.|....||..||||:::..::|:|::.:.||.||..|..
Mouse   134 CEACWRFVFYLCSFVGGTSILYHESWLWSPSLCWENYPHQTLNLSLYWWYLLELGFYLSLLITLP 198

  Fly   202 FDVKRKDFWQMFIHHMVTLLLMSLSWVCNLHRVGSLVLVVHDCADIFLEAAKLTKYAKYQKLCDA 266
            ||||||||.:..:||.|.:.|:..|:..||.|:|::||::|||:|..||..|:..||.:::.|||
Mouse   199 FDVKRKDFKEQVVHHFVAVGLIGFSYSVNLLRIGAVVLLLHDCSDYLLEGCKILNYAHFRRGCDA 263

  Fly   267 IFAIFTVVWIVTRLGFYP-RIIYSSSVEAPRILPMFPAYYIFNSLLLMLLVLHVIWTYMILKIVV 330
            :|.:|.:|:..|||.|:| ::||:|..::.:....|..||.|..||:||.:|||.|..:||:::.
Mouse   264 LFIMFALVFFYTRLIFFPTQVIYTSVYDSIKNSGPFFGYYFFIVLLVMLQILHVYWFCLILRMLY 328

  Fly   331 DSLQKGLMSGDIRSS----DSEDLTDSSGNARLTNGSARSKNKSISSAPSDKGSA 381
            ..|.||.|:.||||.    ||.|....|...:|.||.||....::::.|..:.:|
Mouse   329 SFLHKGQMTEDIRSDVEEPDSSDDEPVSEGPQLKNGMARGSRVAVTNGPRSRAAA 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
schlank	NP_652526.1	homeodomain	75..131	CDD:238039	16/56 (29%)
schlank	NP_652526.1	TLC	135..334	CDD:214789	83/199 (42%)
Cers4	NP_080334.3	Homeobox-like. /evidence=ECO:0000305	67..128		17/60 (28%)
		homeodomain	<83..128	CDD:238039	14/44 (32%)
		TLC	131..332	CDD:214789	83/200 (42%)
		Last loop motif. /evidence=ECO:0000250\|UniProtKB:Q9HA82	291..301		1/9 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..393		13/43 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849118
Domainoid	1	1.000	55	1.000	Domainoid score	I11053
eggNOG	1	0.900	-	-		E1_COG5058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D383274at33208
OrthoFinder	1	1.000	-	-		FOG0000327
OrthoInspector	1	1.000	-	-		otm43825
orthoMCL	1	0.900	-	-		OOG6_100372
Panther	1	1.100	-	-	O	PTHR12560
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R648
SonicParanoid	1	1.000	-	-		X237
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740