DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment schlank and cers5

DIOPT Version :9

Sequence 1:	NP_652526.1	Gene:	schlank / 50392	FlyBaseID:	FBgn0040918	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	NP_955922.1	Gene:	cers5 / 323020	ZFINID:	ZDB-GENE-030131-1740	Length:	387	Species:	Danio rerio

Alignment Length:	382	Identity:	162/382 - (42%)
Similarity:	241/382 - (63%)	Gaps:	16/382 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FWSTHIWLPPNTTWADIAPGSRPDVVHANYKDLIWPIPFAAVVMLVRYTLERFWISPVGKSLGIR 75
            ||:...|||.|.||||:|..: |.|.:.....|:..:|.|..:..||...|||...|....|.|:
Zfish     8 FWNERFWLPHNVTWADLADPA-PGVEYPKAGHLLSALPLALGIFAVRIFFERFIAGPCASMLQIQ 71

  Fly    76 SSRPKKAANVPILEKTYAKSTRL-DKKKLVPLSKQTDMSEREIERWWRLRRAQDKPSTLVKFCEN 139
            :...::|....:|||.:...|:. |.:....||||.|...|:::||:|.||.||||||..||||:
Zfish    72 TELSRRAQPNAVLEKVFTSITKSPDSRHSEGLSKQLDWDVRKVQRWFRHRRNQDKPSTRTKFCES 136

  Fly   140 TWRCIYYLYSFIFGVIVLWDKPWFWDVKSCWYGYPHQSISNDIWWYYMISMSFYWSLTGTQFFDV 204
            .||..:||..|.:|:..||..||.||.:.|||.||:|.:::.:::||:..::|||||..:||.|:
Zfish   137 MWRFTFYLSIFTYGMRFLWQSPWMWDTRQCWYNYPYQVLTSGLYYYYVTELAFYWSLMFSQFTDI 201

  Fly   205 KRKDFWQMFIHHMVTLLLMSLSWVCNLHRVGSLVLVVHDCADIFLEAAKLTKYAKYQKLCDAIFA 269
            |||||..|||||:.|:.|:|.|:|.|:.||||||:.|||.:|..||||||..|||||::||.:|.
Zfish   202 KRKDFLIMFIHHLATIGLISFSYVNNMLRVGSLVMCVHDASDFLLEAAKLANYAKYQRVCDVVFV 266

  Fly   270 IFTVVWIVTRLGFYPRIIYSSSV-EAPRILPMFPAYYIFNSLLLMLLVLHVIWTYMILKIVVDSL 333
            ||.:::..|||..:|..|.:::: |:.:|:..:|::::||.|||:|.|||:.|:|:|.:|...::
Zfish   267 IFGIIFFGTRLIIFPFWILNTTLFESWQIIGPYPSWWLFNFLLLVLQVLHIFWSYLIARIAFKAI 331

  Fly   334 QKGLMSGDIRS---SDSEDLTDSSGNARLTNGSARSKNKSISSAPSDKGSAGGAGSR 387
            .:|.:|.|.||   |.||:.|:::|..||.:.|||.:|          |:.|..||:
Zfish   332 VRGKVSKDDRSDIESSSEEETETTGKERLKSASARGEN----------GTNGHFGSK 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
schlank	NP_652526.1	homeodomain	75..131	CDD:238039	20/56 (36%)
schlank	NP_652526.1	TLC	135..334	CDD:214789	95/199 (48%)
cers5	NP_955922.1	homeodomain	81..128	CDD:238039	19/46 (41%)
cers5	NP_955922.1	TRAM_LAG1_CLN8	132..325	CDD:281751	94/192 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594681
Domainoid	1	1.000	219	1.000	Domainoid score	I2578
eggNOG	1	0.900	-	-		E1_COG5058
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23634
Inparanoid	1	1.050	323	1.000	Inparanoid score	I2485
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D383274at33208
OrthoFinder	1	1.000	-	-		FOG0000327
OrthoInspector	1	1.000	-	-		otm25982
orthoMCL	1	0.900	-	-		OOG6_100372
Panther	1	1.100	-	-	LDO	PTHR12560
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R648
SonicParanoid	1	1.000	-	-		X237
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.830