DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment schlank and CERS6

DIOPT Version :9

Sequence 1:	NP_652526.1	Gene:	schlank / 50392	FlyBaseID:	FBgn0040918	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	NP_001243055.1	Gene:	CERS6 / 253782	HGNCID:	23826	Length:	392	Species:	Homo sapiens

Alignment Length:	372	Identity:	154/372 - (41%)
Similarity:	232/372 - (62%)	Gaps:	20/372 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FWSTHIWLPPNTTWADIAPGSRPDVVHANYKDLIWPIPFAAVVMLVRYTLERFWISPVGKSLGIR 75
            ||:...|||.|.||||:.  :..:......:||....|.|..:.:||...|||...|...:|.|:
Human     8 FWNERFWLPHNVTWADLK--NTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQ 70

  Fly    76 SSRPKKAANVPILEKTYAKSTR-LDKKKLVPLSKQTDMSEREIERWWRLRRAQDKPSTLVKFCEN 139
            ::.|:.|....||||.:...|: .|:|:|..||||.|...|.|:||:|.||.|:|||||.:|||:
Human    71 ANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCES 135

  Fly   140 TWRCIYYLYSFIFGVIVLWDKPWFWDVKSCWYGYPHQSISNDIWWYYMISMSFYWSLTGTQFFDV 204
            .||..:|||.|.:||..|...||.|:.:.|||.||:|.::.|:.:||::.:||||||..:||.|:
Human   136 MWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFTDI 200

  Fly   205 KRKDFWQMFIHHMVTLLLMSLSWVCNLHRVGSLVLVVHDCADIFLEAAKLTKYAKYQKLCDAIFA 269
            |||||..||:||:|::.|::.|:|.|:.|||:|||.:||.||..|||||:..|||:||:||.:|.
Human   201 KRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFV 265

  Fly   270 IFTVVWIVTRLGFYPRIIYSSSV-EAPRILPMFPAYYIFNSLLLMLLVLHVIWTYMILKIVVDSL 333
            :|.||:|.||||.:|..:.:::: |:..|:..:|::::||.|||::..|:..|:|:|:||...::
Human   266 MFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAV 330

  Fly   334 QKGLMS------------GDIRSSDSEDLTDSSG----NARLTNGSA 364
            .:|...            .||.||..|:.::..|    .|..|||::
Human   331 SRGKAGKWNPLHVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTS 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
schlank	NP_652526.1	homeodomain	75..131	CDD:238039	24/56 (43%)
schlank	NP_652526.1	TLC	135..334	CDD:214789	93/199 (47%)
CERS6	NP_001243055.1	homeodomain	80..127	CDD:238039	22/46 (48%)
CERS6	NP_001243055.1	TRAM_LAG1_CLN8	131..324	CDD:367664	91/192 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158724
Domainoid	1	1.000	223	1.000	Domainoid score	I2583
eggNOG	1	0.900	-	-		E1_COG5058
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2534
Isobase	1	0.950	-	0	Normalized mean entropy	S3160
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D383274at33208
OrthoFinder	1	1.000	-	-		FOG0000327
OrthoInspector	1	1.000	-	-		otm41773
orthoMCL	1	0.900	-	-		OOG6_100372
Panther	1	1.100	-	-	O	PTHR12560
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R648
SonicParanoid	1	1.000	-	-		X237
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.780