DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment schlank and cers3a

DIOPT Version :9

Sequence 1:	NP_652526.1	Gene:	schlank / 50392	FlyBaseID:	FBgn0040918	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	XP_002662790.2	Gene:	cers3a / 100332380	ZFINID:	ZDB-GENE-130320-1	Length:	380	Species:	Danio rerio

Alignment Length:	373	Identity:	154/373 - (41%)
Similarity:	222/373 - (59%)	Gaps:	14/373 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDILNEFSNVFWSTHIWLPPNTTWADIAPGSRPDVVHANYKDLIWPIPFAAVVMLVRYTLERFWI 65
            |.::......||...:|||.|.||||:.  ....:|:|....|...:|:|.:.::|||..||...
Zfish     1 MLVIGTLGEWFWWDRLWLPGNLTWADLK--DEDGLVYARPSHLYITLPYALIFLMVRYLFERLIA 63

  Fly    66 SPVGKSLGIRSSRPKKAANVPILEKTY-AKSTRLDKKKLVPLSKQTDMSEREIERWWRLRRAQDK 129
            :|:..||||......:|.:..:||:.: .||....:..:..|.|:...|.|::|||:|.||.||:
Zfish    64 TPLAASLGITEKIRHRAEHNTVLEQHFTTKSKNPGQADIDGLCKKCGWSSRQVERWFRRRRNQDR 128

  Fly   130 PSTLVKFCENTWRCIYYLYSFIFGVIVLWDKPWFWDVKSCWYGYPHQSISNDIWWYYMISMSFYW 194
            |..|.||.|.:||.|:||.:||.|:|.|:|||||::|...|..||.||:.:..:|||.:.||||.
Zfish   129 PGVLKKFREASWRMIFYLLAFIGGIIALYDKPWFYNVPEVWSDYPKQSMLDSQYWYYTVEMSFYL 193

  Fly   195 SLTGTQFFDVKRKDFWQMFIHHMVTLLLMSLSWVCNLHRVGSLVLVVHDCADIFLEAAKLTKYAK 259
            ||.....||||||||.:..|||..||.|::.||..|..|||:|||::||.:||.||:||:..|||
Zfish   194 SLVLRITFDVKRKDFKEQIIHHWATLTLLAFSWCGNYIRVGTLVLLIHDSSDILLESAKIFNYAK 258

  Fly   260 YQKLCDAIFAIFTVVWIVTRLGFYP-RIIYSSSVEAPRILPMFPAYYIFNSLLLMLLVLHVIWTY 323
            :.|.|:.||.:|..|:|:|||..:| .||:.:.|..|...|.|..||.||.:|::||:||:.|.|
Zfish   259 WFKTCNGIFVVFAAVFIITRLIIFPFWIIHCTWVYPPLYYPPFFGYYFFNFMLIVLLMLHIFWAY 323

  Fly   324 MILKIVVDSLQKGLMSGDIRSSDSED---------LTDSSGNARLTNG 362
            :||::|...| .|.::.|.||.:.||         ..|:..:.::|||
Zfish   324 LILRMVKMFL-FGSLTKDERSDNEEDEEDDGETSMTEDNDEHVKVTNG 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
schlank	NP_652526.1	homeodomain	75..131	CDD:238039	17/56 (30%)
schlank	NP_652526.1	TLC	135..334	CDD:214789	98/199 (49%)
cers3a	XP_002662790.2	homeodomain	81..128	CDD:238039	15/46 (33%)
cers3a	XP_002662790.2	TRAM_LAG1_CLN8	134..327	CDD:281751	96/192 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594678
Domainoid	1	1.000	77	1.000	Domainoid score	I8765
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D383274at33208
OrthoFinder	1	1.000	-	-		FOG0000327
OrthoInspector	1	1.000	-	-		otm25982
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12560
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X237
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.950