DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment schlank and cers4b

DIOPT Version :9

Sequence 1:	NP_652526.1	Gene:	schlank / 50392	FlyBaseID:	FBgn0040918	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	XP_005163700.1	Gene:	cers4b / 100330155	ZFINID:	ZDB-GENE-110719-2	Length:	402	Species:	Danio rerio

Alignment Length:	348	Identity:	140/348 - (40%)
Similarity:	206/348 - (59%)	Gaps:	11/348 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDILNEFSNVFWSTHIWLPPNTTWADI--APGSRPDVVHANYKDLIWPIPFAAVVMLVRYTLERF 63
            ||.|:.:   ||...|||||...|.|:  ..|||..:.    :||:..:|.|...:::||..||.
Zfish     1 MDALSRW---FWKQEIWLPPGIVWEDLEEMQGSRRPMP----RDLLLALPLALAFIMLRYAFERR 58

  Fly    64 WISPVGKSLGIRSSRPKKAANVPILEKTYAKSTRLDKK-KLVPLSKQTDMSEREIERWWRLRRAQ 127
            ...|:.:.||::.....|....|.||..|.|::|...: ::..|.||..::.|::|.|:|.||..
Zfish    59 VAFPLSRVLGVKDPVRLKVTPSPSLEAFYTKNSRQPTQIEISGLVKQCGLTHRQVETWFRNRRNL 123

  Fly   128 DKPSTLVKFCENTWRCIYYLYSFIFGVIVLWDKPWFWDVKSCWYGYPHQSISNDIWWYYMISMSF 192
            |:||...||||..||..:||.:|..|::.|.:..||||.:.||.|:|.|.:....:||||:.:||
Zfish   124 DRPSNTTKFCEACWRFAFYLVAFTAGLLSLINTAWFWDQRECWRGFPRQPLQELHYWYYMLELSF 188

  Fly   193 YWSLTGTQFFDVKRKDFWQMFIHHMVTLLLMSLSWVCNLHRVGSLVLVVHDCADIFLEAAKLTKY 257
            ||||......|||||||.:..|||..|:.|:..|:..|..|:|:||::|||.:|..||:||:..|
Zfish   189 YWSLLLCVSVDVKRKDFKEQIIHHFATIFLLGFSYCSNYIRIGTLVMLVHDASDFLLESAKMFNY 253

  Fly   258 AKYQKLCDAIFAIFTVVWIVTRLGFYP-RIIYSSSVEAPRILPMFPAYYIFNSLLLMLLVLHVIW 321
            |.::|.||::|.||..|::||||..:| :|||::.|.:..:...|..||.||:|||:|..||:.|
Zfish   254 AGWKKTCDSLFVIFAAVFLVTRLLVFPSKIIYTTLVLSMEVFEPFLGYYFFNALLLVLQALHIYW 318

  Fly   322 TYMILKIVVDSLQKGLMSGDIRS 344
            .|:||::|...|..|.:..|.||
Zfish   319 AYLILRMVYKFLFLGKLDKDERS 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
schlank	NP_652526.1	homeodomain	75..131	CDD:238039	17/56 (30%)
schlank	NP_652526.1	TLC	135..334	CDD:214789	90/199 (45%)
cers4b	XP_005163700.1	homeodomain	<83..128	CDD:238039	16/44 (36%)
cers4b	XP_005163700.1	TLC	130..330	CDD:214789	90/199 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594676
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D383274at33208
OrthoFinder	1	1.000	-	-		FOG0000327
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100372
Panther	1	1.100	-	-	O	PTHR12560
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R648
SonicParanoid	1	1.000	-	-		X237
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.740