DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and Pard3

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_006531583.1 Gene:Pard3 / 93742 MGIID:2135608 Length:1337 Species:Mus musculus


Alignment Length:1135 Identity:203/1135 - (17%)
Similarity:332/1135 - (29%) Gaps:429/1135 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 KSAALKQDQQQQQ-QQQQESHNNSFNGHHHPPTDTALAPMLSVDRAMSPAQSEDSGLAPERGTTY 80
            |:...|:|:..:. .:...|.:|.|...:...:.:|..||  |||.:...:.::.|...:.    
Mouse   189 KTCDRKKDENYRSLPRDPSSWSNQFQRDNARSSLSASHPM--VDRWLEKQEQDEEGTEEDS---- 247

  Fly    81 ATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGHAADFLAPGDRLHQIDGISTIGLSNQKVMN 145
                                        ..:.|||||                 ..||.|..   
Mouse   248 ----------------------------SRVEPVGHA-----------------DTGLENMP--- 264

  Fly   146 MLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGL-----TLRGGADYPL 205
                            .:||.:..          ||.|  |..:.|.||:     :.|||....|
Mouse   265 ----------------NFSLDDMV----------KLVQ--VPNDGGPLGIHVVPFSARGGRTLGL 301

  Fly   206 IVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQ 270
            :|..:...|...:.......|.::|:::..|..:...:||.:.:                    |
Mouse   302 LVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQHMFR--------------------Q 346

  Fly   271 SVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIA 335
            ::.                                                |.|....::||:..
Mouse   347 AMR------------------------------------------------ARVIWFHVVPAANK 363

  Fly   336 DRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPAHALARRGHTTLGSPK 400
            ::.      :|:...:........||||. ..:.:.|......|       ||.|       :|:
Mouse   364 EQY------EQLSQREKNNYSPGRFSPDS-HCVANRSVANNAPQ-------ALPR-------APR 407

  Fly   401 YSFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTGGIHGSSSLGMGLGLCRAE 465
            .|    :..:...|..:....|..|:.|...||...|...  |...|.::.:..:|..|.:    
Mouse   408 LS----QPPEQLDAHPRLPHSAHASTKPPAAPALAPPSVL--STNVGSVYNTKKVGKRLNI---- 462

  Fly   466 SFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLDAAA 530
               .|...:.|.|..::......|||..:.:..|:|...|.:.|.::||||::.:|   .:|.|.
Mouse   463 ---QLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVN---GVDLAG 521

  Fly   531 MRQ-----LLEGGSSRNGAS---------------NGTPANW-LELEIEFDMPDAVVPASG---- 570
            ..|     ||.........|               |..|:.. ...|.:.:..|.|:...|    
Mouse   522 KSQEEVVSLLRSTKMEGTVSLLVFRQEEAFHPREMNAEPSQMQTPKETKAEDEDVVLTPDGTREF 586

  Fly   571 -VFSVKLLRAGKCGLGLSVSGS----SHG--GLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQ 628
             .|.|.|..:|..|||:||.|:    :|.  |:.:..:..|..|.:.|.||..|.|:||      
Mouse   587 LTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAV------ 645

  Fly   629 HFNVDALLKEEG--------RSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNC---PASGIN 682
              |.::||.:..        ||.:...:......|.:.|.:            |.|   .:.|..
Mouse   646 --NGESLLGKANQEAMETLRRSMSTEGNKRGMIQLIVARRI------------SRCNELRSPGSP 696

  Fly   683 LGMGMGVSTSTD-------HDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLR 740
            ....:.:.|..|       |.|||.                         :..:|::..::..|.
Mouse   697 AAPELPIETELDDRERRISHSLYSG-------------------------IEGLDESPTRNAALS 736

  Fly   741 SGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEE-----EDEQEQMYPGYELNRYASVD 800
            ...|.:|..|.                    |.|..:|.:     ||::                
Mouse   737 RIMGESGKCQL--------------------SPTVNMPHDDTVMIEDDR---------------- 765

  Fly   801 CTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVE 865
            ...|||.:            |..|.||.|..:..:..| .|.....|::.|.|.:.|..:     
Mouse   766 LPVLPPHL------------SDQSSSSSHDDVGFIMTE-AGTWAKATISDSADCSLSPDV----- 812

  Fly   866 GGIAHKNGQIHVGDQLLAIDEHSV--QGM------PLSHATSLLQNLGDLVDLKILRSHDLANGS 922
                         |.:||......  |.|      ..|.|:.|     |.|..:..:|.||.   
Mouse   813 -------------DPVLAFQREGFGRQSMSEKRTKQFSDASQL-----DFVKTRKSKSMDLG--- 856

  Fly   923 HLPQTQAIYAKVQRRPRSPSANTEAS---KESGS----GNANGGGAVNGNSGSGKPR-------- 972
             :.....:.....:|..|||.:...|   |:|.|    ..|.....:|||....:||        
Mouse   857 -IADETKLNTVDDQRAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGNIPFHRPRPRIIRGRG 920

  Fly   973 ---VFHVTLYKDKVY-------DDYGF----------------SVSDGLYERGVFINRIRSGGP- 1010
               .|...:  ||.|       ||.|.                |||....:....:.|..:|.| 
Mouse   921 CNESFRAAI--DKSYDKPMVDDDDEGMETLEEDTEESSRSGRESVSTSSDQPSYSLERQMNGDPE 983

  Fly  1011 --------ADMCGLLKPFDRIMQVNEMKTQ 1032
                    .|..|..|..||..:.:::|.:
Mouse   984 KRDKTERKKDKAGKDKKKDREKEKDKLKAK 1013

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 8/64 (13%)
PDZ_signaling 183..254 CDD:238492 16/75 (21%)
PDZ_signaling 278..375 CDD:238492 10/96 (10%)
PDZ 496..>521 CDD:294084 8/24 (33%)
PDZ_signaling 571..658 CDD:238492 27/100 (27%)
PDZ_signaling 832..913 CDD:238492 16/88 (18%)
PDZ_signaling 973..1055 CDD:238492 19/92 (21%)
Pard3XP_006531583.1 DUF3534 2..83 CDD:338230
PDZ_signaling 272..347 CDD:238492 18/106 (17%)
PDZ_signaling 465..544 CDD:238492 20/81 (25%)
PDZ_signaling 588..681 CDD:238492 27/100 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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