DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and DLG5

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_004738.3 Gene:DLG5 / 9231 HGNCID:2904 Length:1919 Species:Homo sapiens


Alignment Length:1048 Identity:224/1048 - (21%)
Similarity:363/1048 - (34%) Gaps:309/1048 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 ITVERES-----GCLGLTLRGGADYP-------LIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSL 236
            :..|||:     ..||..:..|.:.|       :.||.| ..|.: ..||::..|.|||:::|.|
Human   621 VEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKV-DKGSI-ADGRLRVNDWLLRINDVDL 683

  Fly   237 IGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAA 301
            |.|   :.:|.||...:..|..|:.:....|:...|   :.||.|.:                  
Human   684 INK---DKKQAIKALLNGEGAINMVVRRRKSLGGKV---VTPLHINL------------------ 724

  Fly   302 VPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDE-- 364
                   |....||..:|.  ||:.|::||.|.|.:.|:|:|||::::|:...:::.:.:..|  
Human   725 -------SGQKDSGISLEN--GVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESL 780

  Fly   365 --------VMTIL----DTSTGRGYT---------QMQIMPAHALARRGHTTLGSPKYSFST--- 405
                    .:::|    .:|:..|..         :|....||....:.|......:::.||   
Human   781 LRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTD 845

  Fly   406 ------LESRKSSTAGRQRQRFARK----SSLPLENPACGTPGSTGGSMGTGGIHGSSSLGMGLG 460
                  ||.||..........|..|    ..|.:...||  |.::..|:.:.....|...|.|  
Human   846 IFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQAC--PSASERSLSSFRSDASGDRGFG-- 906

  Fly   461 LCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYS 525
                     |:|......::..||..|..|.|..::.:      ||..|....|....|:     
Human   907 ---------LVDVRGRRPLLPFETEVGPCGVGEASLDK------ADSEGSNSGGTWPKAM----- 951

  Fly   526 LDAAAMRQLLEGGSSRNGASNGTPANWLEL-----EIEFDMPDAVVPASGVFSVKLLRAG----- 580
            |.:.|:.:.|..........:....|..:.     :|::.:| ...||......|  |||     
Human   952 LSSTAVPEKLSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLP-GPGPAHSPQPSK--RAGPLTPP 1013

  Fly   581 ---------KCGLGLSVSGSSHGGLVIS------------DVKMGSPAHRSGSLRSGDILLAVDQ 624
                     |....|..|..|...||.|            ||..|.|.|.|.. |...:.:|...
Human  1014 KPPRRSDSIKFQHRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPP-RKARVRIASSY 1077

  Fly   625 HPVQHFNVDALLKEEGRSQN-PSHSSSDFTTLTIKRI-----------VLPDFLPMSSPIY---- 673
            :|          :.:|.|.: |:..|.| ..||.:::           ..|.|.|..:|:.    
Human  1078 YP----------EGDGDSSHLPAKKSCD-EDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQ 1131

  Fly   674 ----SNC-PASG-INLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSL----KSRTP--------- 719
                ..| |||| ::..:......|..|   ||.:.....|....|:    :|.||         
Human  1132 FLEEQKCVPASGELSPELQEWAPYSPGH---SSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILR 1193

  Fly   720 QPDY----FRV------PSMDDASLQ----SVQ-------------------LRSGSGSNGGNQA 751
            .|.|    .||      |:..||..|    |||                   :|:..|||....:
Human  1194 NPIYTVRSHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSS 1258

  Fly   752 ANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYP----GYELNRYASVDCTALPPPMENKV 812
            |...|             :.:|..:....:......||    |.|....:..:|:. ||.....:
Human  1259 ARLGS-------------SSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECST-PPQSPLNI 1309

  Fly   813 YGSAASSSSKSSGSSLHQIIFT-------------------VRLEPKGGLLGITLAGSEDITKSI 858
            ...::.|.|::|.|:|.:|...                   |:::.....|||::...|  ...|
Human  1310 DTLSSCSQSQTSASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGE--KGGI 1372

  Fly   859 TISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNL--GDLVD-LKILRS----- 915
            .:|.:..|.|||:.| :..|||||..:     |:.|..||.....|  |...| :.||..     
Human  1373 YVSKVTVGSIAHQAG-LEYGDQLLEFN-----GINLRSATEQQARLIIGQQCDTITILAQYNPHV 1431

  Fly   916 HDLA----NGSHL----------------PQTQAIYAKVQRRPRSPSANTEASKESGSGNANGGG 960
            |.|:    :.|||                |:..::...:..:...||  |..:|:|.|..|.   
Human  1432 HQLSSHSRSSSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPS--TPPAKQSSSRIAG--- 1491

  Fly   961 AVNGNSGSGKPRVFHVTLYKDKVYDDYGFSVSDGLYERGVFINRIRSGGPADMCGLLKPFDRIMQ 1025
              :.|..:.:|||  |.:.|.::  :.|..:..|.. .|||:..:....||.....|.|.|.|::
Human  1492 --DANKKTLEPRV--VFIKKSQL--ELGVHLCGGNL-HGVFVAEVEDDSPAKGPDGLVPGDLILE 1549

  Fly  1026 VNEMKTQD 1033
            ...:..::
Human  1550 YGSLDVRN 1557

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084
PDZ_signaling 183..254 CDD:238492 24/81 (30%)
PDZ_signaling 278..375 CDD:238492 23/110 (21%)
PDZ 496..>521 CDD:294084 5/24 (21%)
PDZ_signaling 571..658 CDD:238492 27/113 (24%)
PDZ_signaling 832..913 CDD:238492 24/102 (24%)
PDZ_signaling 973..1055 CDD:238492 14/61 (23%)
DLG5NP_004738.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 98..142
Takusan 130..212 CDD:282652
TPR_MLP1_2 231..353 CDD:285204
COG1340 295..587 CDD:224259
FliJ 310..449 CDD:304890
BAR 417..601 CDD:299863
PDZ_signaling 620..707 CDD:238492 26/90 (29%)
DegQ <702..771 CDD:223343 23/98 (23%)
PDZ_signaling 722..790 CDD:238492 19/94 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 927..1122 44/220 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1150..1187 9/39 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1201..1230 9/28 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1245..1264 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1306 7/35 (20%)
PDZ 1347..1429 CDD:214570 26/89 (29%)
dbPDZ_assoc 1427..1499 CDD:293216 14/78 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1434..1493 12/65 (18%)
PDZ 1499..1582 CDD:214570 16/64 (25%)
SH3_DLG5 1597..1659 CDD:212794
GuKc 1732..1908 CDD:214504
Guanylate_kin 1740..1907 CDD:279019
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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