DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and LNX1

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_001119800.1 Gene:LNX1 / 84708 HGNCID:6657 Length:728 Species:Homo sapiens


Alignment Length:709 Identity:162/709 - (22%)
Similarity:252/709 - (35%) Gaps:205/709 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 HHPPTDTALAPM--LSVDRAMSPAQSEDSGLAPERGTTYATITLPRNALHLAITFAERND---LS 103
            ||..|....|..  |:.||   ..:|:|.  .|: |....|.|.|...:..|.|.:...|   |.
Human   122 HHFQTSCKGASHYGLTKDR---KRRSQDG--CPD-GCASLTATAPSPEVSAAATISLMTDEPGLD 180

  Fly   104 YPPVVGS-------LNPV--GHAADFLA-PGDRLHQIDGISTIGLSNQKVMNMLC-------AGG 151
            .|..|.|       ::||  |.:....| |.:|       |||...:.|.:|...       :|.
Human   181 NPAYVSSAEDGQPAISPVDSGRSNRTRARPFER-------STIRSRSFKKINRALSVLRRTKSGS 238

  Fly   152 SDACPAIVEIEYS----LPECTVSQNSLCVTSKLAQITVER--ESGCLGLTLRGGADYPL---IV 207
            :.|..|....|.|    .||.......|....::..|.:.|  .|..|.:.|.||::.||   |:
Human   239 AVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIII 303

  Fly   208 THVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQSV 272
            .|:...|.:.:.||:.|||.:|:|:.:.:.......|.::::....|...|         |::..
Human   304 QHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLT---------VMREQ 359

  Fly   273 EF-----SMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSG------EKIEESAGVFI 326
            :|     ...|   :..||.:|...::|            ..|:|...      .|::| .||||
Human   360 KFRSRNNGQAP---DAYRPRDDSFHVIL------------NKSSPEEQLGIKLVRKVDE-PGVFI 408

  Fly   327 ASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPAHALARR 391
            .::|...:|.|.|.|...|:||:|:...:.:.  ||:....::..|                .||
Human   409 FNVLDGGVAYRHGQLEENDRVLAINGHDLRYG--SPESAAHLIQAS----------------ERR 455

  Fly   392 GHTTLGSPKYSFSTLESRKSSTAGRQR-----QRFARKSSLPLENPACGTPGSTGGSMGTGGIHG 451
            .|..:               |...|||     |.....|:      ...:||....|.....:|.
Human   456 VHLVV---------------SRQVRQRSPDIFQEAGWNSN------GSWSPGPGERSNTPKPLHP 499

  Fly   452 SSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSG-----AVAIAQIVPDSVADRSGCI 511
            :.:       |..:...:..|.....|:    ||:| |.|.     .:.:..:.|..|..|.|.|
Human   500 TIT-------CHEKVVNIQKDPGESLGM----TVAG-GASHREWDLPIYVISVEPGGVISRDGRI 552

  Fly   512 QAGD----------------RIVAINKMYS----LDAAAMRQ-----------LLEGGSSRNGAS 545
            :.||                ..||:.|..|    |.|..:::           .|:...:....|
Human   553 KTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPS 617

  Fly   546 NGTPA--NWLELEIEFDMPDAVVPASGVFSVKLLRAGKCG-LGLSVSG--SSHGG---LVISDVK 602
            :.:|:  .||||      |..:.....:    :||....| ||..:.|  ..:.|   ..|..:.
Human   618 DWSPSWVMWLEL------PRCLYNCKDI----VLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIV 672

  Fly   603 MGSPAHRSGSLRSGDILLAVDQHPVQ---HFNVDALLKE-EGRSQNPSHSSSDFTTLTI 657
            .|:||:..|.:|.|||||||:.....   |..:..|||| :||           .||||
Human   673 EGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGR-----------ITLTI 720

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 21/77 (27%)
PDZ_signaling 183..254 CDD:238492 20/75 (27%)
PDZ_signaling 278..375 CDD:238492 25/102 (25%)
PDZ 496..>521 CDD:294084 9/40 (23%)
PDZ_signaling 571..658 CDD:238492 31/97 (32%)
PDZ_signaling 832..913 CDD:238492
PDZ_signaling 973..1055 CDD:238492
LNX1NP_001119800.1 mRING-HC-C3HC3D_LNX1 38..79 CDD:319693
modified RING-HC finger (C3HC3D-type) 41..78 CDD:319693
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 178..214 10/42 (24%)
NPXY motif 181..184 1/2 (50%)
Interaction with MAGEB18. /evidence=ECO:0000269|PubMed:20864041 186..244 14/64 (22%)
PDZ_signaling 272..355 CDD:238492 22/91 (24%)
PDZ_signaling 380..460 CDD:238492 24/110 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..494 4/24 (17%)
PDZ_signaling 505..588 CDD:238492 18/87 (21%)
PDZ_signaling 637..721 CDD:238492 31/99 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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