DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and Grip1

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_038935886.1 Gene:Grip1 / 84016 RGDID:621667 Length:1171 Species:Rattus norvegicus


Alignment Length:1301 Identity:337/1301 - (25%)
Similarity:481/1301 - (36%) Gaps:538/1301 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 PTDTALAPMLSVDRAMSPAQSEDS---GLAPERGTTYATITLPRNALHLAITFAERNDLSYPPVV 108
            |.|.|||    |.|...|.:.:.|   .|..:.|||            |.:|.:...|....|.|
  Rat    76 PPDGALA----VRRQSIPEEFKGSTVVELMKKEGTT------------LGLTVSGGIDKDGKPRV 124

  Fly   109 GSLNPVGHAA--DFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVS 171
            .:|...|.||  |.|..||.:..::||:.....:.:::::|...|.   ..::|:||.||..::.
  Rat   125 SNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGE---RVVLEVEYELPPVSIQ 186

  Fly   172 QNSLCVTSKLAQITVERESGCLGLTLRGGA------DYPLIVTHVRPHGPVYKTGRIKPGDRLLR 230
            .:|  |..:..::|:.:|....|..:||||      ..|:::|.|||.||..:.|.||||||||.
  Rat   187 GSS--VMFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLS 249

  Fly   231 VDNVSLIGKTLAEAQQIIK-CGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLV 294
            ||.:.|:|.|.|||..|:| ||...:    |.|||||||:.||..:.||||:|:.:.....||:.
  Rat   250 VDGIRLLGTTHAEAMSILKQCGQEAT----LLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVA 310

  Fly   295 L-----CNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTM 354
            |     ||....|                       |..|..||||||||||.|||.:||||.|.
  Rat   311 LTTSVCCNKQVIV-----------------------IDKIKSASIADRCGALHVGDHILSIDGTS 352

  Fly   355 IEHTAFSPDEVMTILDTSTGRGYTQMQIMPAH--ALARRG------------------------- 392
            :|:...:  |....|..:|.:  .:::|:|.|  .||.:|                         
  Rat   353 MEYCTLA--EATQFLANTTDQ--VKLEILPHHQTRLALKGPDHVKIQRSDRQLPWDPWASSQCSV 413

  Fly   393 HT---------------TLGSPK---------------------YSFS-----TLESRKSSTAGR 416
            ||               .|..||                     ||.|     ||.....||:.|
  Rat   414 HTNHHHNPHHPDHCRVPALAFPKALTPNSPPAMVSSSSPTSMSAYSLSSLNMGTLPRSLYSTSPR 478

  Fly   417 ---QRQRFAR---KSSLPLENPACGTPGSTGGSMGTGGIHGSSSLGMGLGLCRAESFPVLL--DC 473
               .|:|..:   ||||.|                     .||::|:...:...|:..|:|  |.
  Rat   479 GTMMRRRLKKKDFKSSLSL---------------------ASSTVGLAGQVVHTETTEVVLTADP 522

  Fly   474 SHGAGIILSETVSGSGG-SGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLDAA--AMRQLL 535
            ..|.||.|..:|..:.. |....|:.|..||.|:|.|.:|.|||::|||.:.:.|:.  ...|||
  Rat   523 VTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEANQLL 587

  Fly   536 EGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSH----GGL 596
            ...|..:..:         ||||||:.::|:|:||.|.|||.:.....||:::|..|.    ..|
  Rat   588 RDSSITSKVT---------LEIEFDVAESVIPSSGTFHVKLPKKHSVELGITISSPSSRKPGDPL 643

  Fly   597 VISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIV 661
            ||||:|.||.|||:|:|..||.|||:|     :..:|:...|:                      
  Rat   644 VISDIKKGSVAHRTGTLELGDKLLAID-----NIRLDSCSMED---------------------- 681

  Fly   662 LPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRV 726
                   :..|...|                                .|.|.||.|..:      
  Rat   682 -------AVQILQQC--------------------------------EDLVKLKIRKDE------ 701

  Fly   727 PSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGY 791
                                                                :..||||      
  Rat   702 ----------------------------------------------------DNSDEQE------ 708

  Fly   792 ELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITK 856
                                           |||:    ||:||.|:..||.||||::|:|:...
  Rat   709 -------------------------------SSGA----IIYTVELKRYGGPLGITISGTEEPFD 738

  Fly   857 SITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILR------- 914
            .|.||.|.:||:|.:.|.||:||::|||:..|::|.|||.|..|||..|:.|.|||.:       
  Rat   739 PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQPA 803

  Fly   915 -----------SHDLANGSHLP-------QTQAIYAKV--------------------------- 934
                       |.||.:|...|       :...:|...                           
  Rat   804 SSPKKLPIPSHSSDLGDGEEDPSPIQRPGKLSDVYPSTVPSVDSAVDSWDGSGIDASYGSQGTTF 868

  Fly   935 ----------------QR-------RPRSPS------ANTEASKESGSGNANGGGAVN------- 963
                            ||       :|||.:      :|.:..:.:.||.|....:.:       
  Rat   869 QTSGYNFNTYDWRSPKQRASLSPVPKPRSQTYPDVGLSNEDWDRSTASGFAGASDSADAEQEENF 933

  Fly   964 -----------GNSG-------------------------------------------------- 967
                       |.||                                                  
  Rat   934 WSQALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAPTARSQLGRQASFQ 998

  Fly   968 ----------------------------------------SGKPRVFH-VTLYKDKVYDDYGFSV 991
                                                    |..|...| ||||||...:|:||||
  Rat   999 ERSNSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSGMEDFGFSV 1063

  Fly   992 SDGLYERGVFINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQR 1056
            :|||.|:||::..||..||.|:.| |||:||::|||.::|:||||||.|||||.:|:|:::::.|
  Rat  1064 ADGLLEKGVYVKNIRPAGPGDLGG-LKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISR 1127

  Fly  1057 S 1057
            :
  Rat  1128 N 1128

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 15/66 (23%)
PDZ_signaling 183..254 CDD:238492 35/77 (45%)
PDZ_signaling 278..375 CDD:238492 34/101 (34%)
PDZ 496..>521 CDD:294084 12/24 (50%)
PDZ_signaling 571..658 CDD:238492 29/90 (32%)
PDZ_signaling 832..913 CDD:238492 40/80 (50%)
PDZ_signaling 973..1055 CDD:238492 46/82 (56%)
Grip1XP_038935886.1 PDZ_signaling 97..177 CDD:238492 22/94 (23%)
PDZ_signaling 196..279 CDD:238492 36/86 (42%)
PDZ_signaling 294..377 CDD:238492 34/109 (31%)
PDZ_signaling 513..601 CDD:238492 30/96 (31%)
PDZ_signaling 614..698 CDD:238492 35/149 (23%)
PDZ_signaling 714..795 CDD:238492 40/80 (50%)
PDZ_signaling 1045..1125 CDD:238492 46/80 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 105 1.000 Domainoid score I6515
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 432 1.000 Inparanoid score I1658
OMA 1 1.010 - - QHG46788
OrthoDB 1 1.010 - - D42090at33208
OrthoFinder 1 1.000 - - FOG0003379
OrthoInspector 1 1.000 - - otm46189
orthoMCL 1 0.900 - - OOG6_103747
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2278
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.970

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