DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and Pard3

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_112514.1 Gene:Pard3 / 81918 RGDID:620374 Length:1337 Species:Rattus norvegicus


Alignment Length:1135 Identity:207/1135 - (18%)
Similarity:334/1135 - (29%) Gaps:429/1135 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 KSAALKQDQQQQQ-QQQQESHNNSFNGHHHPPTDTALAPMLSVDRAMSPAQSEDSGLAPERGTTY 80
            |:...|:|:..:. .:...|.:|.|...:...:.:|..||  |||.:...:.::.|...:.    
  Rat   189 KTCDRKKDENYRSLPRDPSSWSNQFQRDNARSSLSASHPM--VDRWLEKQEQDEEGTEEDS---- 247

  Fly    81 ATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGHAADFLAPGDRLHQIDGISTIGLSNQKVMN 145
                                        ..:.|||||                 ..||.|..   
  Rat   248 ----------------------------SRVEPVGHA-----------------DTGLENMP--- 264

  Fly   146 MLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGL-----TLRGGADYPL 205
                            .:||.:..          ||.|  |..:.|.||:     :.|||....|
  Rat   265 ----------------NFSLDDMV----------KLVQ--VPNDGGPLGIHVVPFSARGGRTLGL 301

  Fly   206 IVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIK-------CGGHVSGYTNLTIE 263
            :|..:...|...:.......|.::|:::..|..:...:||.:.:       ...||....|.. :
  Rat   302 LVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQHMFRQAMRARVIWFHVVPAANKE-Q 365

  Fly   264 YDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIAS 328
            |:       :.|        :|.||        ||:       .|..:|.|......|    :|:
  Rat   366 YE-------QLS--------QREMN--------NYS-------PGRFSPDSHCVANRS----VAN 396

  Fly   329 ILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPAHALARRGH 393
            ..|.:: .|...||                  .|.|.                 :.||       
  Rat   397 NAPQAL-PRAPRLS------------------QPPEQ-----------------LDAH------- 418

  Fly   394 TTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTGGIHGSSSLGMG 458
                 |:...|...|.|..||                 ||...|.....|:|:  ::.:..:|..
  Rat   419 -----PRLPHSAHASTKPPTA-----------------PALAPPNVLSTSVGS--VYNTKRVGKR 459

  Fly   459 LGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKM 523
            |.:       .|...:.|.|..::......|||..:.:..|:|...|.:.|.::||||::.:|  
  Rat   460 LNI-------QLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVN-- 515

  Fly   524 YSLDAAAMRQ-----LLEGGSSRNGAS---------------NGTPANWLE-LEIEFDMPDAVVP 567
             .:|.|...|     ||.........|               |..|:.... .|.:.:..|.|:.
  Rat   516 -GVDLAGKSQEEVVSLLRSTKMEGTVSLLVFRQEEAFHPREMNAEPSQMQSPKETKAEDEDIVLT 579

  Fly   568 ASG-----VFSVKLLRAGKCGLGLSVSGS----SHG--GLVISDVKMGSPAHRSGSLRSGDILLA 621
            ..|     .|.|.|..:|..|||:||.|:    :|.  |:.:..:..|..|.:.|.||..|.|:|
  Rat   580 PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIA 644

  Fly   622 VDQHPVQHFNVDALLKEEG--------RSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNC-- 676
            |        |.::||.:..        ||.:...:......|.:.|.:            |.|  
  Rat   645 V--------NGESLLGKANQEAMETLRRSMSTEGNKRGMIQLIVARRI------------SRCNE 689

  Fly   677 -PASGINLGMGMGVSTSTD-------HDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDAS 733
             .:.|......:.:.|..|       |.|||.                         :..:|::.
  Rat   690 LRSPGSPAAPELPIETELDDRERRISHSLYSG-------------------------IEGLDESP 729

  Fly   734 LQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEE-----EDEQEQMYPGYEL 793
            .::..|....|.:|..|.                    |.|..:|.:     ||::         
  Rat   730 TRNAALSRIMGESGKCQL--------------------SPTVNMPHDDTVMIEDDR--------- 765

  Fly   794 NRYASVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSI 858
                   ...|||.:            |..|.||.|..:..:..| .|.....|::.|.|.:.|.
  Rat   766 -------LPVLPPHL------------SDQSSSSSHDDVGFIMTE-AGTWAKATISDSADCSLSP 810

  Fly   859 TISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSH-ATSLLQNLGDLVDLKILRSHDLANGS 922
            .:                  |.:||..........:|. .|....|...|..:|..:|..:..| 
  Rat   811 DV------------------DPVLAFQREGFGRQSMSEKRTKQFSNASQLDFVKTRKSKSMDLG- 856

  Fly   923 HLPQTQAIYAKVQRRPRSPSANTEAS---KESGS----GNANGGGAVNGNSGSGKPR-------- 972
             :.....:.....:|..||:.:...|   |:|.|    ..|.....:|||....:||        
  Rat   857 -IADETKLNTVDDQRAGSPNRDVGPSLGLKKSSSLESLQTAVAEVTLNGNIPFHRPRPRIIRGRG 920

  Fly   973 ---VFHVTLYKDKVY-------DDYGF----------------SVSDGLYERGVFINRIRSGGP- 1010
               .|...:  ||.|       ||.|.                |||....:....:.|..:|.| 
  Rat   921 CNESFRAAI--DKSYDKPMVDDDDEGMETLEEDTEESSRSGRESVSTSSDQPSYSLERQMNGDPE 983

  Fly  1011 --------ADMCGLLKPFDRIMQVNEMKTQ 1032
                    .|..|..|..||..:.:::|.:
  Rat   984 KRDKAEKKKDKAGKDKKKDREKEKDKLKAK 1013

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 8/64 (13%)
PDZ_signaling 183..254 CDD:238492 16/82 (20%)
PDZ_signaling 278..375 CDD:238492 16/96 (17%)
PDZ 496..>521 CDD:294084 8/24 (33%)
PDZ_signaling 571..658 CDD:238492 27/100 (27%)
PDZ_signaling 832..913 CDD:238492 14/81 (17%)
PDZ_signaling 973..1055 CDD:238492 19/92 (21%)
Pard3NP_112514.1 DUF3534 1..146 CDD:288873
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..109
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..263 20/124 (16%)
PDZ_signaling 272..347 CDD:238492 18/86 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..441 16/108 (15%)
PDZ_signaling 465..544 CDD:238492 20/81 (25%)
PDZ_signaling 588..681 CDD:238492 27/100 (27%)
Interaction with PRKCI and PRKCZ. /evidence=ECO:0000269|PubMed:9763423 712..936 55/319 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 866..888 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 932..1015 16/82 (20%)
Interaction with FRMD4A. /evidence=ECO:0000250|UniProtKB:Q99NH2 935..1337 15/79 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1028..1055
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1110..1271
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1284..1337
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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