Protein Alignment Grip and GRIP2

DIOPT Version :10

• Sequence 1: NP_572285.2
• Gene: Grip / 50391
• FlyBaseID: FBgn0029830
• Length: 1058
• Species: Drosophila melanogaster
• Sequence 2: XP_011532443.1
• Gene: GRIP2 / 80852
• HGNCID: 23841
• Length: 1050
• Species: Homo sapiens
• Alignment Length: 1229
• Identity: 313/1229 - (25%)
• Similarity: 460/1229 - (37%)
• Gaps: 469/1229 - (38%)

  Fly    65 AQSEDSGLA------PE--RGTTYATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGHAA--D 119
            |...|..||      ||  ||.|...: :.:....|.:|.:...|....|.|.:|.|.|.||  |
Human    32 AGGADVSLACRRQSIPEEFRGITVVEL-IKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSD 95

  Fly   120 FLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQI 184
            .|..||.:..::||....|.:.:::.:|...|.   ..::|:||.||. ...:|:..:.||...:
Human    96 LLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGE---RVVLEVEYELPP-PAPENNPRIISKTVDV 156

  Fly   185 TVERESGCLGLTLRGGA------DYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAE 243
            ::.:|....|..|||||      ..||::|:|||.||..:.|.:|.|||||.||.:.|.|.:.|.
Human   157 SLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHAT 221

  Fly   244 AQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSG 308
            |...::...|.:.:   .:||||:...:|..:.|||::||.:.....||:
Human   222 ALATLRQCSHEALF---QVEYDVATPDTVANASGPLMVEIVKTPGSALGI--------------- 268

  Fly   309 SSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTST 373
            |.|.:|   :...:.:.|..|.|||:.||.|||..||.:||||.|.:||.:..  |...:|.:.:
Human   269 SLTTTS---LRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLL--EATKLLASIS 328

  Fly   374 GR--------GYTQMQIMPAHAL--------------------ARRGH---------------TT 395
            .:        ..:|..:.|:.|:                    .|.||               .:
Human   329 EKVRLEILPVPQSQRPLRPSEAVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRS 393

  Fly   396 LGSPKYSFSTLESRKS-----------------STAGRQRQ-RFARKSSLPLENPACGTPGSTGG 442
            |.|..:|..||....|                 :|.||:|| |...||||.|          ...
Human   394 LSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSL----------ASS 448

  Fly   443 SMGTGG--IH---------GSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAI 496
            ::|.||  :|         |....|.||.|              ..||..:||:     |....:
Human   449 TVGPGGQIVHTETTEVVLCGDPLSGFGLQL--------------QGGIFATETL-----SSPPLV 494

  Fly   497 AQIVPDSVADRSGCIQAGDRIVAINKMYSLDAA--AMRQLLEGGSSRNGASNGTPANWLELEIEF 559
            ..|.|||.|:|.|.:|.|||:::||.:.:.|..  ...|||     |:.|.    |:.:.||:||
Human   495 CFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLL-----RDAAL----AHKVVLEVEF 550

  Fly   560 DMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSH---GGLVISDVKMGSPAHRSGSLRSGDILLA 621
            |:.::|:|:||.|.|||.:.....||:::|.:|.   ..|:|||:|.||.|||:|:|..||.|||
Human   551 DVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLA 615

  Fly   622 VDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMG 686
            :|     :..:|                                         |||
Human   616 ID-----NIRLD-----------------------------------------NCP--------- 625

  Fly   687 MGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQA 751
                       ...|.....:..|.|.||.|
Human   626 -----------MEDAVQILRQCEDLVKLKIR---------------------------------- 645

  Fly   752 ANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSA 816
                                       ::||..:::
Human   646 ---------------------------KDEDNSDEL----------------------------- 654

  Fly   817 ASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQL 881
                 :::|:    :.:||.|:..||.||||::|:|:....|.||||.:.|:|.:.|.|||||::
Human   655 -----ETTGA----VSYTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRI 710

  Fly   882 LAIDEHSVQGMPLSHATSLLQNLGDLVDLKILRSHDL---------------------------- 918
            |||:..|::|.|||.|..|||..|:.|.|||.:..|.
Human   711 LAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGL 775

  Fly   919 -----------------------------ANGSHLPQTQAIYAKVQRR-------------PRSP 941
                                         ..||:.||..|.....|.|             ||..
Human   776 PAARFSPAVPSVDSAVESWDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRT 840

  Fly   942 SANTEASKES------------------GSGNANG-----------------------------G 959
            |.....:.||                  |.....|                             .
Human   841 SYTPTPADESFPEEEEEDDWEPPTSPAPGPAREEGFWRMFGEALEDLESCGQSELLRELEASIMT 905

  Fly   960 GAVNGNSGSGKP---------------------------RVFHVTLYKDKVYDDYGFSVSDGLYE 997
            |.|...:..|:|                           .:..|||:||.:..|:||||||||.|
Human   906 GTVQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDGLLE 970

  Fly   998 RGVFINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQR 1056
            :||:::.:|..|||...| |:||||::|||.::|:||||||.|||:|.|||.:|:|:.|
Human   971 KGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISR 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ_canonical	<96..163	CDD:483948	18/68 (26%)
		PDZ2_GRIP1-2-like	180..265	CDD:467169	31/90 (34%)
		PDZ3_GRIP1-2-like	277..384	CDD:467172	32/114 (28%)
		degP_htrA_DO	<491..659	CDD:273938	57/172 (33%)
		PDZ_canonical	572..>623	CDD:483948	25/53 (47%)
		PDZ6_GRIP1-2-like	830..914	CDD:467171	41/83 (49%)
		PDZ7_GRIP1-2-like	971..1056	CDD:467173	47/111 (42%)
GRIP2	XP_011532443.1	PDZ1_GRIP1-2-like	54..136	CDD:467175	21/85 (25%)
		PDZ2_GRIP1-2-like	152..240	CDD:467169	31/90 (34%)
		PDZ3_GRIP1-2-like	252..337	CDD:467172	31/104 (30%)
		PDZ4_GRIP1-2-like	455..555	CDD:467174	36/127 (28%)
		PDZ5_GRIP1-2-like	563..646	CDD:467170	36/209 (17%)
		PDZ6_GRIP1-2-like	659..743	CDD:467171	41/87 (47%)
		PDZ7_GRIP1-2-like	944..1028	CDD:467173	46/84 (55%)