DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and GRIP2

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_011532443.1 Gene:GRIP2 / 80852 HGNCID:23841 Length:1050 Species:Homo sapiens


Alignment Length:1229 Identity:313/1229 - (25%)
Similarity:460/1229 - (37%) Gaps:469/1229 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 AQSEDSGLA------PE--RGTTYATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGHAA--D 119
            |...|..||      ||  ||.|...: :.:....|.:|.:...|....|.|.:|.|.|.||  |
Human    32 AGGADVSLACRRQSIPEEFRGITVVEL-IKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSD 95

  Fly   120 FLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQI 184
            .|..||.:..::||....|.:.:::.:|...|.   ..::|:||.||. ...:|:..:.||...:
Human    96 LLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGE---RVVLEVEYELPP-PAPENNPRIISKTVDV 156

  Fly   185 TVERESGCLGLTLRGGA------DYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAE 243
            ::.:|....|..|||||      ..||::|:|||.||..:.|.:|.|||||.||.:.|.|.:.|.
Human   157 SLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHAT 221

  Fly   244 AQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSG 308
            |...::...|.:.:   .:||||:...:|..:.|||::||.:.....||:               
Human   222 ALATLRQCSHEALF---QVEYDVATPDTVANASGPLMVEIVKTPGSALGI--------------- 268

  Fly   309 SSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTST 373
            |.|.:|   :...:.:.|..|.|||:.||.|||..||.:||||.|.:||.:..  |...:|.:.:
Human   269 SLTTTS---LRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLL--EATKLLASIS 328

  Fly   374 GR--------GYTQMQIMPAHAL--------------------ARRGH---------------TT 395
            .:        ..:|..:.|:.|:                    .|.||               .:
Human   329 EKVRLEILPVPQSQRPLRPSEAVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRS 393

  Fly   396 LGSPKYSFSTLESRKS-----------------STAGRQRQ-RFARKSSLPLENPACGTPGSTGG 442
            |.|..:|..||....|                 :|.||:|| |...||||.|          ...
Human   394 LSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTMGRRRQRRREHKSSLSL----------ASS 448

  Fly   443 SMGTGG--IH---------GSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAI 496
            ::|.||  :|         |....|.||.|              ..||..:||:     |....:
Human   449 TVGPGGQIVHTETTEVVLCGDPLSGFGLQL--------------QGGIFATETL-----SSPPLV 494

  Fly   497 AQIVPDSVADRSGCIQAGDRIVAINKMYSLDAA--AMRQLLEGGSSRNGASNGTPANWLELEIEF 559
            ..|.|||.|:|.|.:|.|||:::||.:.:.|..  ...|||     |:.|.    |:.:.||:||
Human   495 CFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLL-----RDAAL----AHKVVLEVEF 550

  Fly   560 DMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSH---GGLVISDVKMGSPAHRSGSLRSGDILLA 621
            |:.::|:|:||.|.|||.:.....||:::|.:|.   ..|:|||:|.||.|||:|:|..||.|||
Human   551 DVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLA 615

  Fly   622 VDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMG 686
            :|     :..:|                                         |||         
Human   616 ID-----NIRLD-----------------------------------------NCP--------- 625

  Fly   687 MGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQA 751
                       ...|.....:..|.|.||.|                                  
Human   626 -----------MEDAVQILRQCEDLVKLKIR---------------------------------- 645

  Fly   752 ANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSA 816
                                       ::||..:::                             
Human   646 ---------------------------KDEDNSDEL----------------------------- 654

  Fly   817 ASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQL 881
                 :::|:    :.:||.|:..||.||||::|:|:....|.||||.:.|:|.:.|.|||||::
Human   655 -----ETTGA----VSYTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRI 710

  Fly   882 LAIDEHSVQGMPLSHATSLLQNLGDLVDLKILRSHDL---------------------------- 918
            |||:..|::|.|||.|..|||..|:.|.|||.:..|.                            
Human   711 LAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGL 775

  Fly   919 -----------------------------ANGSHLPQTQAIYAKVQRR-------------PRSP 941
                                         ..||:.||..|.....|.|             ||..
Human   776 PAARFSPAVPSVDSAVESWDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRT 840

  Fly   942 SANTEASKES------------------GSGNANG-----------------------------G 959
            |.....:.||                  |.....|                             .
Human   841 SYTPTPADESFPEEEEEDDWEPPTSPAPGPAREEGFWRMFGEALEDLESCGQSELLRELEASIMT 905

  Fly   960 GAVNGNSGSGKP---------------------------RVFHVTLYKDKVYDDYGFSVSDGLYE 997
            |.|...:..|:|                           .:..|||:||.:..|:||||||||.|
Human   906 GTVQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDGLLE 970

  Fly   998 RGVFINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQR 1056
            :||:::.:|..|||...| |:||||::|||.::|:||||||.|||:|.|||.:|:|:.|
Human   971 KGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIISR 1028

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 17/66 (26%)
PDZ_signaling 183..254 CDD:238492 28/76 (37%)
PDZ_signaling 278..375 CDD:238492 30/96 (31%)
PDZ 496..>521 CDD:294084 11/24 (46%)
PDZ_signaling 571..658 CDD:238492 27/89 (30%)
PDZ_signaling 832..913 CDD:238492 40/80 (50%)
PDZ_signaling 973..1055 CDD:238492 46/81 (57%)
GRIP2XP_011532443.1 PDZ_signaling 53..135 CDD:238492 21/85 (25%)
PDZ_signaling 155..238 CDD:238492 29/85 (34%)
PDZ_signaling 253..336 CDD:238492 30/102 (29%)
PDZ_signaling 461..549 CDD:238492 32/115 (28%)
PDZ_signaling 562..645 CDD:238492 35/148 (24%)
PDZ_signaling 662..742 CDD:238492 40/79 (51%)
PDZ_signaling 947..1026 CDD:238492 45/79 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 103 1.000 Domainoid score I6778
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 378 1.000 Inparanoid score I2085
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46788
OrthoDB 1 1.010 - - D42090at33208
OrthoFinder 1 1.000 - - FOG0003379
OrthoInspector 1 1.000 - - otm42044
orthoMCL 1 0.900 - - OOG6_103747
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5842
SonicParanoid 1 1.000 - - X2278
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.910

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