DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and PDZD7

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_001182192.1 Gene:PDZD7 / 79955 HGNCID:26257 Length:1033 Species:Homo sapiens


Alignment Length:1017 Identity:195/1017 - (19%)
Similarity:308/1017 - (30%) Gaps:324/1017 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 AERNDLSYPPVVGSLN-------PVGHAADFLAPGDRLH----QIDGISTIGLSNQK-----VMN 145
            |||..|.....:..:|       .:|.|...|....|||    ::..:..|..|.:|     |:|
Human   122 AERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVN 186

  Fly   146 MLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRGGADYPL-IVTH 209
            .         ..:||...|.|..|.|::.:   .::..:....:..|||..:|||.::.| |...
Human   187 R---------RLVVEKCGSTPSDTSSEDGV---RRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVS 239

  Fly   210 VRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHV----------SGYTNLTIEY 264
            ...||.:.:...||.||::|..:.|.....:.::|.:::|...|:          ..|..:..||
Human   240 KVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYKEMVSEY 304

  Fly   265 DVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIASI 329
                            ..::|..|..|       ....|||.|.||..|.......|:|     .
Human   305 ----------------CWLDRLSNGVL-------QQLSPASESSSSVSSCASSAPYSSG-----S 341

  Fly   330 LPASIADRCGALSVGDQVLSIDDTMIEHTAFSP-----DEVMTILDTSTGRGYTQMQIMPAHAL- 388
            ||:...|.|    :|.:         |..:..|     |..|.....:.||..|...:.|...| 
Human   342 LPSDRMDIC----LGQE---------EPGSRGPGWGRADTAMQTEPDAGGRVETWCSVRPTVILR 393

  Fly   389 -----------ARRGHTTLG-SPK-----------------YSFSTL----ESRKSSTAGRQRQR 420
                       .||..:.|. |||                 .|:.||    :.||...:|...::
Human   394 DTAIRSDGPHPGRRLDSALSESPKTALLLALSRPRPPITRSQSYLTLWEEKQQRKKEKSGSPGEK 458

  Fly   421 FARKSSLPLENPACGTPGSTGGSMGTGGIHGSSSLGMGLGLCRAESFPVLLDCSHGAGI------ 479
            .|.:.|..|.|  ....|...|.:...|...:.:|..|   ..|:::| .||.....|:      
Human   459 GALQRSKTLMN--LFFKGGRQGRLARDGRREAWTLDSG---SLAKTYP-RLDIEKAGGVGPVQKF 517

  Fly   480 -------------ILSETVSGSGGSGAVAIAQIVP------DSVADRSGCIQAGDRIVAINKMYS 525
                         .|....|||..|....:.:.|.      ..:.|.:..:...|.::|:.:..|
Human   518 VTWRLRRDQERGRALLSARSGSPSSQLPNVDEQVQAWESRRPLIQDLAQRLLTDDEVLAVTRHCS 582

  Fly   526 LDAAAMRQLLEGGSSRNGASNGTPANWLELEIE---------FDMPDAVVPASGVFSVKLLRAGK 581
                  |.:.|||                  ||         .|.|:.::....:.||    ...
Human   583 ------RYVHEGG------------------IEDLVRPLLAILDRPEKLLLLQDIRSV----VAP 619

  Fly   582 CGLG------LSVSGSSHGGL--------VISDVKMGSPAHRS-----GSLRSGDILLAVDQHPV 627
            ..||      :.|...:...|        .:...:..:|..|.     ...|.|..||.|:..|.
Human   620 TDLGRFDSMVMLVELEAFEALKSRAVRPPALRPARQDTPPKRHLITPVPDSRGGFYLLPVNGFPE 684

  Fly   628 QHFNVD-----ALLKEEGRSQNPSHSSSD-----------FTTLTI------------KRIVLPD 664
            :..|.:     ..||....:..|.|....           ||.|.|            .|.:.|:
Human   685 EEDNGELRERLGALKVSPSASAPRHPHKGIPPLQDVPVDAFTPLRIACTPPPQLPPVAPRPLRPN 749

  Fly   665 FLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSM 729
            :| ::.|:....|......|.....|.|.......|:. ..||     |...|:|.|.....|||
Human   750 WL-LTEPLSREHPPQSQIRGRAQSRSRSRSRSRSRSSR-GQGK-----SPGRRSPSPVPTPAPSM 807

  Fly   730 DDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELN 794
                           :||.......          ..||        ||...|.:          
Human   808 ---------------TNGRYHKPRK----------ARPP--------LPRPLDGE---------- 829

  Fly   795 RYASVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAG--SEDITKS 857
               :....|...|.|:...|:|..::.|:....|.    ||.|......|||:::|  ...:...
Human   830 ---AAKVGAKQGPSESGTEGTAKEAAMKNPSGELK----TVTLSKMKQSLGISISGGIESKVQPM 887

  Fly   858 ITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILRSHDLANGS 922
            :.|..:..||.|..:|.:..|.:|:|:|..:::.:....|...::.                   
Human   888 VKIEKIFPGGAAFLSGALQAGFELVAVDGENLEQVTHQRAVDTIRR------------------- 933

  Fly   923 HLPQTQAIYAKVQRRP-----RSPSANTEASKESGSGNANGG 959
                   .|....|.|     |.|..:...|....|...:||
Human   934 -------AYRNKAREPMELVVRVPGPSPRPSPSDSSALTDGG 968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 16/65 (25%)
PDZ_signaling 183..254 CDD:238492 18/71 (25%)
PDZ_signaling 278..375 CDD:238492 21/101 (21%)
PDZ 496..>521 CDD:294084 4/30 (13%)
PDZ_signaling 571..658 CDD:238492 23/133 (17%)
PDZ_signaling 832..913 CDD:238492 17/82 (21%)
PDZ_signaling 973..1055 CDD:238492
PDZD7NP_001182192.1 PDZ_signaling 84..164 CDD:238492 11/41 (27%)
PDZ_signaling 209..289 CDD:238492 19/79 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..380 16/74 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..464 4/19 (21%)
HN_PDZD7_like 554..630 CDD:259824 16/103 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 754..864 30/165 (18%)
PDZ_signaling 860..948 CDD:238492 21/117 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 943..1033 6/26 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.