DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and Grip1

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_006514294.1 Gene:Grip1 / 74053 MGIID:1921303 Length:1185 Species:Mus musculus


Alignment Length:1301 Identity:335/1301 - (25%)
Similarity:481/1301 - (36%) Gaps:538/1301 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 PTDTALAPMLSVDRAMSPAQSEDS---GLAPERGTTYATITLPRNALHLAITFAERNDLSYPPVV 108
            |.|.|||    |.|...|.:.:.|   .|..:.|||            |.:|.:...|....|.|
Mouse    89 PPDGALA----VRRQSIPEEFKGSTVVELMKKEGTT------------LGLTVSGGIDKDGKPRV 137

  Fly   109 GSLNPVGHAA--DFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVS 171
            .:|...|.||  |.|..||.:..::||:.....:.:::::|...|.   ..::|:||.||..:|.
Mouse   138 SNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGE---RVVLEVEYELPPVSVQ 199

  Fly   172 QNSLCVTSKLAQITVERESGCLGLTLRGGA------DYPLIVTHVRPHGPVYKTGRIKPGDRLLR 230
            .:|  |..:..::|:.:|....|..:||||      ..|:::|.|||.||..:.|.||||||||.
Mouse   200 GSS--VMFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLS 262

  Fly   231 VDNVSLIGKTLAEAQQIIK-CGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLV 294
            ||.:.|:|.|.|||..|:| ||...:    |.|||||||:.||..:.||||:|:.:.....||:.
Mouse   263 VDGIRLLGTTHAEAMSILKQCGQEAT----LLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVA 323

  Fly   295 L-----CNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTM 354
            |     ||....|                       |..|..||||||||||.|||.:||||.|.
Mouse   324 LTTSVCCNKQVIV-----------------------IDKIKSASIADRCGALHVGDHILSIDGTS 365

  Fly   355 IEHTAFSPDEVMTILDTSTGRGYTQMQIMPAH--ALARRG------------------------- 392
            :|:...:  |....|..:|.:  .:::|:|.|  .||.:|                         
Mouse   366 MEYCTLA--EATQFLANTTDQ--VKLEILPHHQTRLALKGPDHVKIQRSDRQHPWDAWASNQCGV 426

  Fly   393 HT---------------TLGSPK---------------------YSFS-----TLESRKSSTAGR 416
            ||               .|..||                     ||.|     ||.....||:.|
Mouse   427 HTNHHHNTYHPDHCRVPALTFPKALPPNSPPAMVPSSSPTSMSAYSLSSLNMGTLPRSLYSTSPR 491

  Fly   417 ---QRQRFAR---KSSLPLENPACGTPGSTGGSMGTGGIHGSSSLGMGLGLCRAESFPVLL--DC 473
               .|:|..:   ||||.|                     .||::|:...:...|:..|:|  |.
Mouse   492 GTMMRRRLKKKDFKSSLSL---------------------ASSTVGLAGQVVHTETTEVVLTADP 535

  Fly   474 SHGAGIILSETVSGSGG-SGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLDAA--AMRQLL 535
            ..|.||.|..:|..:.. |....|:.|..||.|:|.|.:|.|||::|||.:.:.|:.  ...|||
Mouse   536 VTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEANQLL 600

  Fly   536 EGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSH----GGL 596
            ...|..:..:         ||||||:.::|:|:||.|.|||.:.....||:::|..|.    ..|
Mouse   601 RDSSITSKVT---------LEIEFDVAESVIPSSGTFHVKLPKKHSVELGITISSPSSRKPGDPL 656

  Fly   597 VISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIV 661
            ||||:|.||.|||:|:|..||.|||:|...:.:.:::..::                        
Mouse   657 VISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQ------------------------ 697

  Fly   662 LPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRV 726
                      |...|                                .|.|.||.|..:      
Mouse   698 ----------ILQQC--------------------------------EDLVKLKIRKDE------ 714

  Fly   727 PSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGY 791
                                                                :..||||      
Mouse   715 ----------------------------------------------------DNSDEQE------ 721

  Fly   792 ELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITK 856
                                           |||:    ||:||.|:..||.||||::|:|:...
Mouse   722 -------------------------------SSGA----IIYTVELKRYGGPLGITISGTEEPFD 751

  Fly   857 SITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILR------- 914
            .|.||.|.:||:|.:.|.||:||::|||:..|::|.|||.|..|||..|:.|.|||.:       
Mouse   752 PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSA 816

  Fly   915 -----------SHDLANGSHLPQ------------------------------TQAIY------- 931
                       |.||.:|...|.                              ..|.|       
Mouse   817 SSPKKFPIPGHSGDLGDGEEDPSPIQKPGKLSDAYPSTVPSVDSAVDSWDGSGIDASYGSQGSTF 881

  Fly   932 -------------AKVQR-------RPRSPS------ANTEASKESGSGNANGGGAVN------- 963
                         :..||       :|||.:      :|.:..:.:.||......:.:       
Mouse   882 QTSGYNYNTYDWRSPKQRTSLSPVPKPRSQTYPDVGLSNEDWDRSTASGFVGASDSADAEQEENF 946

  Fly   964 -----------GNSG-------------------------------------------------- 967
                       |.||                                                  
Mouse   947 WSQALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAPMARSQLGRQASFQ 1011

  Fly   968 ---SGKP--------------------------------------RVFHVTLYKDKVYDDYGFSV 991
               |.:|                                      .:..||||||...:|:||||
Mouse  1012 ERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSGMEDFGFSV 1076

  Fly   992 SDGLYERGVFINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQR 1056
            :|||.|:||::..||..||.|:.| |||:||::|||.::|:||||||.|||||.:|:|:::::.|
Mouse  1077 ADGLLEKGVYVKNIRPAGPGDVGG-LKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISR 1140

  Fly  1057 S 1057
            :
Mouse  1141 N 1141

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 15/66 (23%)
PDZ_signaling 183..254 CDD:238492 35/77 (45%)
PDZ_signaling 278..375 CDD:238492 34/101 (34%)
PDZ 496..>521 CDD:294084 12/24 (50%)
PDZ_signaling 571..658 CDD:238492 27/90 (30%)
PDZ_signaling 832..913 CDD:238492 40/80 (50%)
PDZ_signaling 973..1055 CDD:238492 45/81 (56%)
Grip1XP_006514294.1 PDZ_signaling 110..190 CDD:238492 22/94 (23%)
PDZ_signaling 209..292 CDD:238492 36/86 (42%)
PDZ_signaling 307..390 CDD:238492 34/109 (31%)
PDZ_signaling 526..614 CDD:238492 30/96 (31%)
PDZ_signaling 627..711 CDD:238492 33/149 (22%)
PDZ_signaling 727..808 CDD:238492 40/80 (50%)
PDZ_signaling 1058..1138 CDD:238492 45/80 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 104 1.000 Domainoid score I6691
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 390 1.000 Inparanoid score I1978
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46788
OrthoDB 1 1.010 - - D42090at33208
OrthoFinder 1 1.000 - - FOG0003379
OrthoInspector 1 1.000 - - otm44099
orthoMCL 1 0.900 - - OOG6_103747
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5842
SonicParanoid 1 1.000 - - X2278
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.860

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