DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and Ush1c

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_710143.2 Gene:Ush1c / 72088 MGIID:1919338 Length:910 Species:Mus musculus


Alignment Length:975 Identity:191/975 - (19%)
Similarity:322/975 - (33%) Gaps:273/975 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 HAADFLAPGD-----------RLHQIDGISTIGLSNQKVMN-----MLCAGGSDACPAIVEIEYS 164
            |..|||...|           ..||...::.:....:.|:|     .|........|...::||.
Mouse    11 HKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPNRLPLFDAIRPLIPLKHQVEYD 75

  Fly   165 LPECTVSQNSLCVTSKLAQITVER--ESGCLGLTLRGGADY--PLIVTHVRPHGPVYKTGRIKPG 225
              :.|..:     :.||.::.::|  ..| |||::|||.::  .|.::|:...|.....| ::.|
Mouse    76 --QLTPRR-----SRKLKEVRLDRLHPEG-LGLSVRGGLEFGCGLFISHLIKGGQADSVG-LQVG 131

  Fly   226 DRLLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDV------SVVQSVEFSM-------- 276
            |.::|::..|:...|..|...:|:        |..|:...|      .|..|.|.|:        
Mouse   132 DEIVRINGYSISSCTHEEVINLIR--------TKKTVSIKVRHIGLIPVKSSPEESLKWQYVDQF 188

  Fly   277 --------GPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPAS 333
                    |.|.....|...:|...:     :.|.:.|.|.|. |||.  .:..|:|::.:.|.|
Mouse   189 VSESGGVRGGLGSPGNRTTKEKKVFI-----SLVGSRGLGCSI-SSGP--IQKPGIFVSHVKPGS 245

  Fly   334 IADRCGALSVGDQVL---SIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPAHALARRGHTT 395
            ::...| |..|||::   .||.|.::|     .|.:.:|.:|  |..| :.|:            
Mouse   246 LSAEVG-LETGDQIVEVNGIDFTNLDH-----KEAVNVLKSS--RSLT-ISIV------------ 289

  Fly   396 LGSPKYSFSTLESRKSSTAGR--QRQRFARKSSLPLENPACGTPGSTGGSMGTGGIHGSSSLGMG 458
            .|:.:..|.|...|......|  |||....:..|.:|                            
Mouse   290 AGAGRELFMTDRERLEEARQRELQRQELLMQKRLAME---------------------------- 326

  Fly   459 LGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKM 523
                              :..||.|..............:...::...|....|..:......|.
Mouse   327 ------------------SNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQISEEEEKFKKQ 373

  Fly   524 YSLDAAAMRQLL--------------------------EG--GSSRNGASNGTPANWLEL----- 555
            :..|..:..||:                          :|  .:.|..|.....|.:..|     
Mouse   374 WKEDWGSKEQLILPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKAKEKKKAKYDSLQDLRK 438

  Fly   556 ---EIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSHGGLVISDVKMGSPAHRSGSLRSGD 617
               |:||:..........:...|.|:..:  |...||.:....|..|: |......|....|...
Mouse   439 NKKELEFEQKLYKEKEEMLEKEKQLKINR--LAQEVSETEREDLEESE-KTQYWVERLCQTRLEQ 500

  Fly   618 ILLAVDQHPVQHF-------NVDALLKEEGRSQNPSH-SSSDFTTLTIKRIVLPDFLPMSSPIY- 673
            |..|.::.|....       :|..|.....|.....| .::|...:.:.....|...|.:.|:. 
Mouse   501 ISSAENEIPEMTTGPPPPPPSVSPLAPPLRRFAGGIHLHTTDLDDIPLDMFYYPPKTPSALPVMP 565

  Fly   674 --------SNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYF----RV 726
                    |..||..:....| .||:|      ||.:|            .|||.|...    .:
Mouse   566 HPPSVNPPSKVPAPPVLPSSG-HVSSS------SSPWV------------QRTPPPIPIPPPPSI 611

  Fly   727 PSMD-----------DASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEE 780
            |:.|           :.:|.:...|:|...:    .|:.|....:|....:.|.|:......|:.
Mouse   612 PTQDLTPTRPLPSALEEALGNHPFRTGDPGH----PADDWEANTHSGKPSSSPTTERSFPPAPKT 672

  Fly   781 --EDEQEQMYPG----------YELNRYA---SVDCTALPPPMENK--VYGSAASSSSKS----- 823
              ...|....||          ::.:.:.   :|....||..|..:  ||.:|.....:.     
Mouse   673 FCPSPQPPRGPGVSTISKPVMVHQEHNFVYRPAVKSEVLPQEMLKRMVVYQTAFRQDFRKYEEGF 737

  Fly   824 ---SGSSLHQI----IFTVRLEPKGGLLGITLAGSEDI-TKSITISGLVEGGIAHKNGQIHVGDQ 880
               |..|..||    :..:|:: |.|.|.:.|.|..|. ...:.:|.:.|||.|.::|.:..||:
Mouse   738 DPYSMFSPEQIAGKDVRLLRIK-KEGSLDLALEGGVDSPVGKVVVSAVYEGGAAERHGGVVKGDE 801

  Fly   881 LLAIDEHSVQGMPLSHATSLLQNL----GDLVDLKIL----RSHDLANGSHLPQTQAIYAKVQRR 937
            ::||:...|....|:.|.:.||..    ||.:||.:.    :.:| ...|.||.:.|...::.|:
Mouse   802 IMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYD-DELSSLPSSAAESPQLARK 865

  Fly   938  937
            Mouse   866  865

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 9/46 (20%)
PDZ_signaling 183..254 CDD:238492 19/74 (26%)
PDZ_signaling 278..375 CDD:238492 26/99 (26%)
PDZ 496..>521 CDD:294084 2/24 (8%)
PDZ_signaling 571..658 CDD:238492 18/94 (19%)
PDZ_signaling 832..913 CDD:238492 26/85 (31%)
PDZ_signaling 973..1055 CDD:238492
Ush1cNP_710143.2 N-terminal domain. /evidence=ECO:0000250|UniProtKB:Q9Y6N9 1..86 15/81 (19%)
harmonin_N 2..80 CDD:259819 14/70 (20%)
PDZ_signaling 85..165 CDD:238492 22/89 (25%)
Mediates interaction with MYO7B. /evidence=ECO:0000250|UniProtKB:Q9Y6N9 194..833 141/740 (19%)
PDZ_signaling 209..289 CDD:238492 26/96 (27%)
Cgr1 <309..>358 CDD:281823 9/94 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 563..688 28/147 (19%)
PDZ_signaling 751..838 CDD:238492 26/87 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 890..910
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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