Protein Alignment Grip and Pdzph1

DIOPT Version :9

• Sequence 1: NP_572285.2
• Gene: Grip / 50391
• FlyBaseID: FBgn0029830
• Length: 1058
• Species: Drosophila melanogaster
• Sequence 2: NP_081277.1
• Gene: Pdzph1 / 69239
• MGIID: 1916489
• Length: 1238
• Species: Mus musculus
• Alignment Length: 1123
• Identity: 202/1123 - (17%)
• Similarity: 349/1123 - (31%)
• Gaps: 345/1123 - (30%)

  Fly    10 IGGCVPGK-SAALKQDQQQQQQQQQESHNNSFNGHHHPPTDTALAPMLSV----DRAMSPAQSED 69
            |...:.|| :::.....::|.......|.:..||:..|.....|..:|.|    ||..|
Mouse    53 ITASINGKQNSSFLVKNEKQAPSDSTIHKSMENGYTPPAISPQLEEVLPVAMFNDREKS------ 111

  Fly    70 SGLAPERGTTYATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGHAADFLAPGDRLHQID-GI 133
               .|.:.||.                      .:|..|..|.|        |.|..:.::. |.
Mouse   112 ---LPGKITTE----------------------DFPNTVEVLKP--------AKGKFIREVKCGA 143

  Fly   134 STIGLSNQKVMNMLCAGGSD-----ACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCL 193
            ..:.:...|  ::.|..|:.     .||...: .||:.:......|....||...:..|.....:
Mouse   144 FNVHVETTK--SIFCKTGAQNLTKRRCPTCHQ-HYSVQQVWRGSKSRGHFSKHRTVLAEEFKRRV 205

  Fly   194 GLTLRGG---ADYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVS 255
            ..|.|.|   ::.|.:                          |:|::||.:. .:.|.|     .
Mouse   206 PSTYRRGVSRSEVPSV--------------------------NISIVGKEIM-VEYISK-----K 238

  Fly   256 GYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVP---------------AS 305
            ..|.:.|.:..|:.:..:...|||....:.|         |. :|:.|               :|
Mouse   239 QNTFINICHPNSIGKLTKHRRGPLKHTTDEP---------CE-SASQPGINHPENQRLENQHQSS 293

  Fly   306 GSGSSTPSSGEKIE-ESAGVFIASIL--PASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMT 367
            .:....|.|...:: |::...:.|:.  |....::...|....     ||:....:|.||.:|:.
Mouse   294 DAFHDAPCSVNAVQKENSDTIVVSLSSPPRREKEKPNTLPSAP-----DDSEEGESATSPQKVLQ 353

  Fly   368 ILDTS--TGRGYTQMQIMPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLE 430
            |....  ....:|....:|..:...| .|:|.:...|..:||..:.....|:.....|::..|..
Mouse   354 ITQDKPLEQHCFTADSCLPTSSETLR-TTSLNNVDLSKMSLEDSRDVDEERKNSSDVRENITPDS 417

  Fly   431 NPACGTPGSTGGSMGTGGIHGSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVA 495
            .....|.|:.|.......|                 .|:             :..|||..|....
Mouse   418 QVQPCTAGTNGPLSAVNSI-----------------IPI-------------QDASGSEFSPLSF 452

  Fly   496 IAQIVPDSVADRSGCIQAGDRIVAINKMYSLDAAAMRQLLEGGSSRNGASNGTPANWLELEIEFD 560
            :...:..:.||..||  .|:..:.               .||..|.|             .:.|.
Mouse   453 LTLQLLGAKADNMGC--RGEETLP---------------GEGHESSN-------------SLLFP 487

  Fly   561 MPDAVVPASGVFSVKLLRAGKCG-----LGLSVSGSSHGGLVISDVKMGSPAHRSGSLRSGDILL 620
            :.:.....|.:.|.. .|..:|.     .|.:.|.|.:.|:.....|:........||
Mouse   488 VSEQAAKPSPLLSPS-HRVSRCSEPVETTGNTFSFSQYIGVEREQEKVHYRLINKASL------- 544

  Fly   621 AVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGM 685
                |.....|:..|.:::  .|:|:      .|:....|::|     .||::.|..:|
Mouse   545 ----HNDSSSNIQPLERKD--PQSPA------VTIASCSILVP-----KSPLHGNIHSS------ 586

  Fly   686 GMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQ 750
             :..:.:.||          ..:|:...| ||...|....:.:..:.||.:...:..:
Mouse   587 -VEWNQTEDH----------ANHAERAGL-SRMEVPVMASITNELEQSLATQNYKEST------- 632

  Fly   751 AANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYP--------GYE-LNRYASVDCTALPP 806
                    |:|.|.:|..|.:..|:.|....|:..|..|        .:| |.|....:..:...
Mouse   633 --------VDSNSPMAIRNPRESTSYLENVGDDASQALPVVKNMCHRNFEDLTRENQNEICSQMD 689

  Fly   807 PMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDIT-----KSITISGL--- 863
            .::|       ||.|.|.|.:..::.          |:..|||..:|..     |:..::..
Mouse   690 FLQN-------SSESTSVGHTTEKLF----------LIDKTLASDDDSNSNRDHKTCGLNNFQQE 737

  Fly   864 -------------VEGGIAHKNGQI--HVGDQLLAIDEHSV---QGMPLSHATSLLQNLGDLVDL 910
                         .|.|......::  |..|.||:..:...   |.:.:::...|.|.|.
Mouse   738 PAECQRTTSRVYCEESGNQRYPTEVSCHPVDILLSPQKQKALKDQNLEINNPRKLSQELA----- 797

  Fly   911 KILRSHDLANGSHLPQTQAIYAKVQRRPRSPSANTEASKESGSGNANGGGAVNGNSGSGKPRVFH 975
              ||....::||   |.:||....:||        :..|:....::.||.:|..|...|
Mouse   798 --LRGGRASDGS---QEEAIEQWARRR--------QQFKDGKRCSSAGGSSVISNFTEG------ 843

  Fly   976 VTLYKDKVYD-DYGFSVSDGLYERGVFINRIRS---------GGPADMCGLLKPFDRIMQVNEMK 1030
             ::..|.|:. |:||.|.  :.|:|.:.....|         |.|.|....|....|.:.|.|.
Mouse   844 -SITSDDVHSVDFGFRVD--IEEKGFYTENFHSTAWVFRGDDGNPEDSPRCLSKKPRPVAVRER- 904

  Fly  1031 TQDFDCCLTVPLIAAAGD 1048
                    ||.|....||
Mouse   905 --------TVRLFKGTGD 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084	8/65 (12%)
		PDZ_signaling	183..254	CDD:238492	11/73 (15%)
		PDZ_signaling	278..375	CDD:238492	20/116 (17%)
		PDZ	496..>521	CDD:294084	5/24 (21%)
		PDZ_signaling	571..658	CDD:238492	16/91 (18%)
		PDZ_signaling	832..913	CDD:238492	16/106 (15%)
		PDZ_signaling	973..1055	CDD:238492	21/86 (24%)
Pdzph1	NP_081277.1	PDZ_signaling	903..981	CDD:238492	6/21 (29%)
		PH-like	986..1093	CDD:302622
		PH	993..1094	CDD:278594
		PH-like	1123..1215	CDD:302622
		PH	1125..1216	CDD:278594

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900