DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip and Slc9a3r2

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_075542.2	Gene:	Slc9a3r2 / 65962	MGIID:	1890662	Length:	337	Species:	Mus musculus

Alignment Length:	197	Identity:	45/197 - (22%)
Similarity:	80/197 - (40%)	Gaps:	14/197 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   864 VEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILRSHDLANGSHLPQTQ 928
            ||.|...:...:..||:|:.::..:|:|.........::.:.....|.::   |......|.:.|
Mouse    39 VEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTQLLVV---DKETDEELCRRQ 100

  Fly   929 -AIYAKVQRRPRSPSANTEASKE----SGS-GNANGGGAVNGNSGSGKPRVFHVTLYKDKVYDDY 987
             ....::..|...|:.|....|.    ||| |:..|...|||.....:||:.|:.    :....|
Mouse   101 LTCTEEMAHRGLPPAHNPWEPKPDWACSGSLGSDTGQKDVNGPPRELRPRLCHLR----RGPQGY 161

  Fly   988 GFSVSDGLYERGVFINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEM 1052
            ||::.......|.:|..:..|.||...| |:..||:::||....:.......|..|.|..|:..:
Mouse   162 GFNLHSDKSRPGQYIRSVDPGSPASHSG-LRAQDRLIEVNGQNVEGLRHAEVVARIKAQEDEARL 225

  Fly  1053 IM 1054
            ::
Mouse   226 LV 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084
		PDZ_signaling	183..254	CDD:238492
		PDZ_signaling	278..375	CDD:238492
		PDZ	496..>521	CDD:294084
		PDZ_signaling	571..658	CDD:238492
		PDZ_signaling	832..913	CDD:238492	9/48 (19%)
		PDZ_signaling	973..1055	CDD:238492	19/82 (23%)
Slc9a3r2	NP_075542.2	PDZ_signaling	9..88	CDD:238492	9/48 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..147		11/34 (32%)
		PDZ	148..230	CDD:214570	21/85 (25%)
		EBP50_C	232..337	CDD:286142
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..337
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900