DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and Pdzk1

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_113900.1 Gene:Pdzk1 / 65144 RGDID:70924 Length:523 Species:Rattus norvegicus


Alignment Length:506 Identity:114/506 - (22%)
Similarity:190/506 - (37%) Gaps:106/506 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   583 GLGLSVSGSSHGGLVISDVKMGSPAHRSGSLRSGDILLA-----VDQHPVQHFNVDALLKEEGRS 642
            |..|.:...:.|.|| ..::.||||.::| |..||.:|.     ||:.  :|..|..|:::.|.|
  Rat    21 GFFLRIEKDTDGHLV-RVIEEGSPAEKAG-LLDGDRVLRINGVFVDKE--EHAQVVDLVRKSGNS 81

  Fly   643 ------QNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSA 701
                  ...|:..:....:.:|.:   |..|....:....|    :|||..||.|.....|   .
  Rat    82 VTLLVLDGDSYEKAVKHQVDLKEL---DQSPREPALNEKKP----DLGMNGGVETCAQPRL---C 136

  Fly   702 YVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVA 766
            |:.....:...|||:...:...|    :.|.:.|.|.:::                ||.:..::.
  Rat   137 YLVKEGNSFGFSLKTIQGKKGVF----LTDITPQGVAMKA----------------GVLADDHLI 181

  Fly   767 PPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSSL--- 828
            ..|.:::  |....|:..|::........:..||       .|.....|...:..|...:||   
  Rat   182 EVNGENV--ENASHEEVVEKVTKSGSRIMFLLVD-------KETARCHSEQKTPFKRETASLKLL 237

  Fly   829 -HQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGM 892
             ||....|..:...|......||.|.  |...|..:..|..|...| :...|.::|::..||:.:
  Rat   238 PHQPRVVVIKKGSNGYGFYLRAGPEQ--KGQIIKDIEPGSPAEAAG-LKNNDLVVAVNGESVEAL 299

  Fly   893 PLSHATSLLQNLGDLVDLKIL-------------------RSHDLANGSHLPQTQAIYAKVQRRP 938
            .......:::|.||...|.:|                   :|.:|.|||           |:..|
  Rat   300 DHDSVVEMIRNGGDQTTLLVLDKEADRIYSLARFSPLLYCQSQELPNGS-----------VKEAP 353

  Fly   939 RSPSANTEASKESGSGNANGGGAVNGNSGSGKPRVFHVTLYKDKVYDDYGFSVSDGLYERGVFIN 1003
            ...||..||.          |.|...:.|..||::..:.    |..|.|||.::....:.|.|:.
  Rat   354 APISAPLEAP----------GSATTEDVGDHKPKLCRLI----KEDDSYGFHLNAIRGQPGSFVK 404

  Fly  1004 RIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIM 1054
            .::.|||||..| |:..|.|::||....||......|..|.::|:.:.:::
  Rat   405 EVQQGGPADKAG-LENEDIIIEVNGENVQDEPYDRVVERIKSSGEHVTLLV 454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084
PDZ_signaling 183..254 CDD:238492
PDZ_signaling 278..375 CDD:238492
PDZ 496..>521 CDD:294084
PDZ_signaling 571..658 CDD:238492 22/85 (26%)
PDZ_signaling 832..913 CDD:238492 18/80 (23%)
PDZ_signaling 973..1055 CDD:238492 23/82 (28%)
Pdzk1NP_113900.1 PDZ_signaling 7..87 CDD:238492 21/69 (30%)
PDZ 132..212 CDD:214570 15/104 (14%)
PDZ_signaling 242..320 CDD:238492 18/80 (23%)
PDZ 375..455 CDD:214570 25/85 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 479..523
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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