DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and PTPN14

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_005392.2 Gene:PTPN14 / 5784 HGNCID:9647 Length:1187 Species:Homo sapiens


Alignment Length:591 Identity:109/591 - (18%)
Similarity:180/591 - (30%) Gaps:159/591 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   511 IQAGDRIVAINKMYSLDAAAMRQLLEGG------SSRNGAS----NGTPANWLELEIEFDMPDAV 565
            :|.|:.       ||....:...:..|.      :|.|...    |||..|           .:|
Human   342 VQCGEH-------YSETHTSQDSIFHGNEEALYCNSHNSLDLNYLNGTVTN-----------GSV 388

  Fly   566 VPASGVFSV----KLLRAGKCGLGLSVSGSSHGGLVISDVKMGS--PAHRSGSLRSGDILLAVDQ 624
            .....|.|:    ..::|......||:.|        ||:....  |:||..::.........|.
Human   389 CSVHSVNSLNCSQSFIQASPVSSNLSIPG--------SDIMRADYIPSHRHSAIIVPSYRPTPDY 445

  Fly   625 HPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGV 689
            ..|.......:|..:.:||    |..:...:.......|:.|..|.|                  
Human   446 ETVMRQMKRGILHTDSQSQ----SLRNLNIINTHAYNQPEDLVYSQP------------------ 488

  Fly   690 STSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANS 754
             ...:...|:..|...|.|::.:...|....|....|||...||..|..:.:...:|...|.:::
Human   489 -EMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTPELANMQLQGSHN 552

  Fly   755 WSTGVNSRSYV--APPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAA 817
            :||....::|:  .||         |..........|....:|:..|..:: |..:..||..|..
Human   553 YSTAHMLKNYLFRPPP---------PYPRPRPATSTPDLASHRHKYVSGSS-PDLVTRKVQLSVK 607

  Fly   818 SSSSKSSGSSLHQIIFTVRLEPKGG--------------LLGITLAGSEDIT-KSITISGLVEGG 867
            :....|| ..:||.:..|. ||...              ::...:.|.|.:| ||:.:.      
Human   608 TFQEDSS-PVVHQSLQEVS-EPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKSLHLP------ 664

  Fly   868 IAHKNGQIHVGDQLLAIDEHSVQGMPLSH-------ATSLLQNL----------GDLVDLKILRS 915
            :|.:|.....|........|.|..:|..|       ||.|:.:.          ..:..:.:||.
Human   665 MARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPESVPQIPMLRE 729

  Fly   916 HDLANGSHLPQTQAIYAKVQRRPRSPSANTEASKESG---------------------------S 953
                ...:..|.||..|::..:|.........|..:|                           |
Human   730 ----KMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARVLRHGPAKAIS 790

  Fly   954 GNANGGGAVNGNSGSGKPRVFHVTLYKDKVYDD--------YGFSVSDGLYERGVFINRIRSGGP 1010
            .:.....||||.|.........:|..|::|..:        ..||:.|.:.||.:.|..:..   
Human   791 MSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEK--- 852

  Fly  1011 ADMCGL 1016
            ..|.||
Human   853 QKMAGL 858

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084
PDZ_signaling 183..254 CDD:238492
PDZ_signaling 278..375 CDD:238492
PDZ 496..>521 CDD:294084 2/9 (22%)
PDZ_signaling 571..658 CDD:238492 17/92 (18%)
PDZ_signaling 832..913 CDD:238492 18/112 (16%)
PDZ_signaling 973..1055 CDD:238492 12/52 (23%)
PTPN14NP_005392.2 B41 24..220 CDD:214604
FERM_C_PTPN14_PTPN21 215..305 CDD:270009
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..531 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 671..690 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 787..824 9/36 (25%)
PTPc 935..1179 CDD:238006
Substrate binding. /evidence=ECO:0000250 1121..1127
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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