DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and PTPN13

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_011530467.1 Gene:PTPN13 / 5783 HGNCID:9646 Length:2507 Species:Homo sapiens


Alignment Length:1210 Identity:248/1210 - (20%)
Similarity:402/1210 - (33%) Gaps:408/1210 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 SAALKQDQQQQQQQQQE--------------SHNNSFNGHHHPPTDTALAPMLSVDRAMSPAQSE 68
            |:..|.|:...:::.:|              .|..:...:..||..|....:......||.:.:|
Human   949 SSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAE 1013

  Fly    69 DSGLAPERGTTYATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGHAADFLAPGDRLHQID-- 131
                      :.|.:|...|:..:|                |||        .:|..|.|:.|  
Human  1014 ----------SLAGVTKLNNSKSVA----------------SLN--------RSPERRKHESDSS 1044

  Fly   132 GISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSK------LAQITVERES 190
            .|...|.:....|.|..:|.|.:       :..|.|..|......:.|.      |..:..:.:.
Human  1045 SIEDPGQAYVLGMTMHSSGNSSS-------QVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKY 1102

  Fly   191 GCLGLTLRGG-----ADYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKC 250
            | ||..:.||     .|..:.::.|.|.||....|.:||||||:.|::|||.|.:...|.:|:: 
Human  1103 G-LGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQ- 1165

  Fly   251 GGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLV----------LCNY------- 298
                      ....||::|             |.:| .:|:..|          :.||       
Human  1166 ----------NAPEDVTLV-------------ISQP-KEKISKVPSTPVHLTNEMKNYMKKSSYM 1206

  Fly   299 -TAAV-----------------------PASGSGSSTPSSGEKIEESAGV-------FIASILPA 332
             .:|:                       |:.|....:.||.:...|||.:       |.||.|  
Human  1207 QDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHL-- 1269

  Fly   333 SIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQ-----IMPAHALARRG 392
                       |||.....    :|.:.||..:....:..|.....|.:     |......:.||
Human  1270 -----------GDQTWQES----QHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRG 1319

  Fly   393 HTTLGSPKYSFS----TLESRKSSTAG-RQRQRFARKSSLPLENPACGTPGSTGGSMGTGGIHGS 452
            .:.:....||.|    |.:...||:.. ..:..|...||         :|...|...........
Human  1320 DSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSS---------SPPKPGDIFEVELAKND 1375

  Fly   453 SSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRI 517
            :|||:        |..||.|         ...|:.|...|.:.:..::|...|:..|.|..|||:
Human  1376 NSLGI--------SVTVLFD---------KGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRV 1423

  Fly   518 VAINKMYSLDAAAMRQ--------------LLEGGSSRNGASN--GTPANWL-ELEIEFDMPDAV 565
            :|:|.: ||:.|..:|              |||.|.|.....:  .||...| :...:...|:.|
Human  1424 LAVNGV-SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKV 1487

  Fly   566 -----------VPASGVFSVKLLRAGKCGLGLSVSGSSH------GGLVISDVKM--GSPAHRSG 611
                       |.....|.|||.: ...|||.|.|...:      ...::...|:  |.||..||
Human  1488 KKTTQVKDYSFVTEENTFEVKLFK-NSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1551

  Fly   612 SLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRI-------VLPD----- 664
            .:..||::|.|:         .|.||  |.||....|:...|...:..:       |||:     
Human  1552 KIDVGDVILKVN---------GASLK--GLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTAL 1605

  Fly   665 FLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSM 729
            ..|:.||. ...|.|..:......|..||..|        ..:.:|....:.::|.    |..|.
Human  1606 LTPLQSPA-QVLPNSSKDSSQPSCVEQSTSSD--------ENEMSDKSKKQCKSPS----RRDSY 1657

  Fly   730 DDASLQSVQLRSGSGSNG-----GNQAANSWSTGVN---------SRSYVAPPNTQSLT------ 774
            .|:        ||||.:.     .|.:.::||:.::         ::|:...|.:|..|      
Human  1658 SDS--------SGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFY 1714

  Fly   775 -----TELPEEEDEQEQMYPGYELNRYASVDCTALPPPM-ENKVYGSAASSSSKSSGSSLH---- 829
                 ...||.||...                :.|||.| ..:.|...:.|:|.||....|    
Human  1715 YPQKIPNKPEFEDSNP----------------SPLPPDMAPGQSYQPQSESASSSSMDKYHIHHI 1763

  Fly   830 ---------------------------QIIFTVRLEPKGGLLGITLA-GSEDITKSITISGLVEG 866
                                       :::.|: ::.:.|.||.|:. |::.|  ...:..:::.
Human  1764 SEPTRQENWTPLKNDLENHLEDFELEVELLITL-IKSEKGSLGFTVTKGNQRI--GCYVHDVIQD 1825

  Fly   867 GIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILRSHDLANGSHLPQTQAIY 931
            . |..:|::..||:|:.:::..|..|..:.|.:||:.....|.|                   :.
Human  1826 P-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRL-------------------VI 1870

  Fly   932 AKVQRRPRSPSANTEASKESGSGNANGGGAVNGNSGSGKPRVF-HVTLYKDKVYDDYGFSV---S 992
            .:|...||.|..                           |.:. .:||..:|  ::.|||:   .
Human  1871 GRVLELPRIPML---------------------------PHLLPDITLTCNK--EELGFSLCGGH 1906

  Fly   993 DGLYERGVFINRIRSGGPADMCGLLKPFDRIMQVNEMKTQ 1032
            |.||: .|:|:.|.....|.:.|.|:..|.|..||.:.||
Human  1907 DSLYQ-VVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1945

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 13/66 (20%)
PDZ_signaling 183..254 CDD:238492 24/75 (32%)
PDZ_signaling 278..375 CDD:238492 25/144 (17%)
PDZ 496..>521 CDD:294084 8/24 (33%)
PDZ_signaling 571..658 CDD:238492 27/94 (29%)
PDZ_signaling 832..913 CDD:238492 19/81 (23%)
PDZ_signaling 973..1055 CDD:238492 21/64 (33%)
PTPN13XP_011530467.1 KIND 3..190 CDD:214801
B41 573..781 CDD:214604
FERM_N 576..638 CDD:286467
FERM_M 668..781 CDD:278785
PH-like 777..877 CDD:302622
PDZ_signaling 1091..1175 CDD:238492 28/108 (26%)
PTN13_u3 1177..1367 CDD:293207 39/216 (18%)
PDZ_signaling 1366..1455 CDD:238492 24/106 (23%)
PDZ 1503..1594 CDD:214570 27/102 (26%)
PDZ_signaling 1791..1870 CDD:238492 19/101 (19%)
PDZ_signaling 1888..1966 CDD:238492 21/61 (34%)
PTPc 2236..2488 CDD:214550
PTPc 2262..2488 CDD:238006
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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