DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and PTPN4

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_002821.1 Gene:PTPN4 / 5775 HGNCID:9656 Length:926 Species:Homo sapiens


Alignment Length:501 Identity:91/501 - (18%)
Similarity:158/501 - (31%) Gaps:160/501 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   644 NPSHSSSDFTT----LTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTST-DHDL------ 697
            :|:....::|.    |.||:.:|...||        ||::...|.....|.:.. |:|.      
Human   113 DPNKLQEEYTRYQYFLQIKQDILTGRLP--------CPSNTAALLASFAVQSELGDYDQSENLSG 169

  Fly   698 YSSAY------------VTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQ 750
            |.|.|            ..|..:...:.|.....:.:|..       :.::::|.........:|
Human   170 YLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEFNYLN-------TARTLELYGVEFHYARDQ 227

  Fly   751 AANSWSTGVNSRSYVAPPNTQSLTT------------------ELPEEEDEQEQMYPGYELNRYA 797
            :.|....||.|...:...|...:.|                  :|.:|..|..:...|:.:..|.
Human   228 SNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYR 292

  Fly   798 SVDCTAL---------------PPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGIT 847
            :  |..|               |.|.:...:....:..||        ..:..|.|.:....|..
Human   293 A--CKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSK--------FRYCGRTEVQSVQYGKE 347

  Fly   848 LAGSEDI-----TKSITISGLVEGGIAHKNGQIHVGDQLL---AIDEHSVQGMPLSHATSLL--- 901
            .|..:.:     :|.:. ..|::..:..:|.   :.|..|   ::...|..|.| :|..|..   
Human   348 KANKDRVFARSPSKPLA-RKLMDWEVVSRNS---ISDDRLETQSLPSRSPPGTP-NHRNSTFTQE 407

  Fly   902 ------QNLGDLVDLKILRSHDLANGSHLPQTQAIYAKV-QRRPRSPSANTEASKESGSGNANGG 959
                  .::|.|||             |:..|......| ||.|.|..||:...:.|.|....|.
Human   408 GTRLRPSSVGHLVD-------------HMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGD 459

  Fly   960 GA-----------------------------VNGN----SGSGKPR----VFHVTLYKDKVYDD- 986
            |.                             :|..    |...||.    :.|..|...::..| 
Human   460 GKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDE 524

  Fly   987 ---YGFSVSDGLYER-GVFINRIRSGGPADMC-GLLKPFDRIMQVN 1027
               :||:|..|..:: .|.::|:..|.|||:| ..|...|:::.:|
Human   525 NGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLIN 570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084
PDZ_signaling 183..254 CDD:238492
PDZ_signaling 278..375 CDD:238492
PDZ 496..>521 CDD:294084
PDZ_signaling 571..658 CDD:238492 3/17 (18%)
PDZ_signaling 832..913 CDD:238492 18/97 (19%)
PDZ_signaling 973..1055 CDD:238492 17/61 (28%)
PTPN4NP_002821.1 B41 30..222 CDD:214604 21/123 (17%)
FERM_C_PTPN4_PTPN3_like 216..310 CDD:270010 15/95 (16%)
FA 325..365 CDD:312314 7/48 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..412 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 430..475 11/44 (25%)
PDZ_signaling 515..602 CDD:238492 16/56 (29%)
PTPc 682..909 CDD:238006
Substrate binding. /evidence=ECO:0000250 852..858
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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