DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip and LRRC7

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_001357714.1	Gene:	LRRC7 / 57554	HGNCID:	18531	Length:	1575	Species:	Homo sapiens

Alignment Length:	824	Identity:	158/824 - (19%)
Similarity:	260/824 - (31%)	Gaps:	305/824 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 FSPDEVMTILDTSTGRG----YTQMQIMPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQR 420
            |||.......|::..|.    ::|:...|.   :.:|..::.......|.|.....|...::.|.
Human   926 FSPGVPWEYHDSNPNRSLSNVFSQIHCRPE---SSKGVISISKSTERLSPLMKDIKSNKFKKSQS 987

  Fly   421 F-------ARKSSLPLENPACGTPGSTGGSMGT--------GGIHGSSSLGMGLGLCRAESFPVL 470
            .       .:..::||||.|.|:     ..:|:        |..||.||:.      |::|.|:|
Human   988 IDEIDIGTYKVYNIPLENYASGS-----DHLGSHERPDKMLGPEHGMSSMS------RSQSVPML 1041

  Fly   471 LD--CSHGAG-------------IILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAI 520
            .|  .::|:.             :...:......||..|...:.:|.........:|...:.:|
Human  1042 DDEMLTYGSSKGPQQQKASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIA- 1105

  Fly   521 NKMYSLDAAAMRQLLEGGSSRNGASNGTPANWLELEIEFDMP----DAVVPASGVFSVKLLRAGK 581
                       :.|:   |.|  |..|.|.  :|....|..|    ||||.|
Human  1106 -----------KDLI---SPR--AYRGYPP--MEQMFSFSQPSVNEDAVVNA------------- 1139

  Fly   582 CGLGLSVSGSSHGGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPS 646
                                :..|...|:|.||..|.|::..:..:
Human  1140 --------------------QFASQGARAGFLRRADSLVSATEMAM------------------- 1165

  Fly   647 HSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTA------ 705
                      .:|:..|..||.:.. |...|..|     |:        |..||..||.
Human  1166 ----------FRRVNEPHELPPTDR-YGRPPYRG-----GL--------DRQSSVTVTESQFLKR 1206

  Fly   706 -GKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSG-----SNGGNQAANSWST----GVN 760
             |:|.|        ..|.|           |.|:.::||.     :.....:|.|:||    ...
Human  1207 NGRYED--------EHPSY-----------QEVKAQAGSFPVKNLTQRRPLSARSYSTESYGASQ 1252

  Fly   761 SRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYA-----SVDCTALPPPMENKVYGSAASSS 820
            :|...|.|...:|..::|.:          |.|..|.     :.|....|.|::.:      .|.
Human  1253 TRPVSARPTMAALLEKIPSD----------YNLGNYGDKPSDNSDLKTRPTPVKGE------ESC 1301

  Fly   821 SKSSGSSLHQIIFTV---RLEPKGGLLGITLAGSEDITKSITISGLVEGGIA--HKNGQIHVGDQ 880
            .|.......|::..:   ||:........|          :.:..|..|||:  |....:.:..|
Human  1302 GKMPADWRQQLLRHIEARRLDRNAAYKHNT----------VNLGMLPYGGISAMHAGRSMTLNLQ 1356

  Fly   881 LLAIDEHSVQGMPL----SHATSLLQN---------------LG------DLVDLKILRSHDLAN 920
            ..:..:|  |.:||    |..:::|.|               ||      |.:..|.
Human  1357 TKSKFDH--QELPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKA-------- 1411

  Fly   921 GSHLPQTQAIYAKVQRRPRSPSANTEASKESGSGNAN----------------GGGAVNG----- 964
            |||: ||......:|.|.|        .::...||.|                ...|..|
Human  1412 GSHI-QTLMGSQSLQHRSR--------EQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGR 1467

  Fly   965 --------NSGSGKPRVFHVTLYKDKVYDDYGFSVSDGL---------YERGVFINRIRSGGPAD 1012
                    .|..|.|..|.|.:.|:   ...|||:|.|:         .::|:|:.|::..|||.
Human  1468 CLIQTKGQRSMDGYPEQFCVRIEKN---PGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPAS 1529

  Fly  1013 MCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQR 1056
              .||:|.|:|:|.|.......:....|.|:.:..:.:::::||
Human  1530 --NLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQR 1571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084
		PDZ_signaling	183..254	CDD:238492
		PDZ_signaling	278..375	CDD:238492	4/14 (29%)
		PDZ	496..>521	CDD:294084	3/24 (13%)
		PDZ_signaling	571..658	CDD:238492	7/86 (8%)
		PDZ_signaling	832..913	CDD:238492	20/110 (18%)
		PDZ_signaling	973..1055	CDD:238492	23/90 (26%)
LRRC7	NP_001357714.1	leucine-rich repeat	64..85	CDD:275380
		LRR_8	85..140	CDD:338972
		leucine-rich repeat	86..108	CDD:275380
		leucine-rich repeat	109..131	CDD:275380
		LRR	130..440	CDD:227223
		leucine-rich repeat	132..177	CDD:275380
		leucine-rich repeat	178..200	CDD:275380
		leucine-rich repeat	201..223	CDD:275380
		leucine-rich repeat	224..246	CDD:275380
		leucine-rich repeat	247..269	CDD:275380
		leucine-rich repeat	270..292	CDD:275380
		leucine-rich repeat	316..336	CDD:275380
		leucine-rich repeat	339..361	CDD:275380
		leucine-rich repeat	362..384	CDD:275380
		leucine-rich repeat	385..407	CDD:275380
		leucine-rich repeat	408..430	CDD:275380
		PDZ_signaling	1485..1570	CDD:238492	23/89 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23119
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100