DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip and pdzd2

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_003198698.3	Gene:	pdzd2 / 569088	ZFINID:	ZDB-GENE-060526-297	Length:	2433	Species:	Danio rerio

Alignment Length:	1156	Identity:	235/1156 - (20%)
Similarity:	360/1156 - (31%)	Gaps:	436/1156 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 IDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVE-----RE 189
            |.|.|.:.:||...:      ||.|         :|| |. |::.:....|...|:.|     ||
Zfish   288 ITGPSELMMSNHMRV------GSTA---------TLP-CR-SRSRMSENFKTESISSEPSGQPRE 335

  Fly   190 SG------------CLGLTLRGG-----ADYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLI 237
            .|            .||:.:.||     :.:.:||.||...|...:.||:|.||.||.::..||:
Zfish   336 GGRIWKMHMVKGQDGLGIQITGGRGSKRSPHGIIVAHVEEGGATQRDGRLKAGDELLMINGHSLV 400

  Fly   238 GKTLAEAQQIIKCGGHVSGYTNLTI-EYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAA 301
            |.:..||..|::   ..:|...|.: ..|.|   .|:|...|                    :.:
Zfish   401 GLSHQEAVAILR---STAGLVQLVVASRDES---EVDFHKYP--------------------STS 439

  Fly   302 VP-----ASGSGSSTPSSGEKIEESAGVFIASILPASIAD-RCGALSVGDQVLSIDDTMIEH--- 357
            :|     .||..:| ||.||:.|.         :...:.| |..:||:..|.|..|...::.
Zfish   440 LPDLVSTCSGPDAS-PSPGEEKEN---------MEPDMEDVRASSLSLPTQDLFTDHDRLDERGR 494

  Fly   358 ------TAFSPDEVMTILDTSTGRGYTQMQIM--PAHALARRGHT--------TLGSPKYSFSTL 406
                  ...||.. |.....|.|.| ::::.:  ....:...|.|        |.|..|:|.
Zfish   495 IEGPKGCCRSPTP-MKFRSRSQGGG-SRLESVGEDDELIVENGDTGSDVAEKPTRGGRKHSL--- 554

  Fly   407 ESRKSSTAG-RQRQRFARKSSLPLENPACGTPGSTGGSMGTGGIHGSSSLGMGLGLCRAESFPVL 470
             .::..|.| ||..:..:||:..|......:|...........|......|.|||..
Zfish   555 -PQQLDTVGIRQEYQIVKKSARSLSTVQVESPWRLAQPSIISNIVLMKGQGKGLGFS-------- 610

  Fly   471 LDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAIN-------------- 521
                     |:....|..|..| :.:..|.|:..|...|.::.||.|:.:|
Zfish   611 ---------IVGGQDSARGRMG-IFVKTIFPNGAAAADGRLKEGDEILEVNGESLQGLTHQQAIQ 665

  Fly   522 ------------------KMYSLDAAAMRQLLEGGSSRN-GASNGTPANWLELEIEFDMPDAVVP 567
                              :..||.......||...||.| .||.|||     :...||..|:
Zfish   666 TFKQLKKGVVTLTVRTRLRSPSLTPCPTPTLLSRSSSPNSNASGGTP-----VPQSFDEGDS--- 722

  Fly   568 ASG-------VFSVKLLRAGKCGLGLSVS----GSSHGGLVISDVKMGSPAHRSGSLRSGDILLA 621
            ..|       :..|.|.:....|||:...    .:|..|:.|..:..||.|...|.|..||.||.
Zfish   723 RKGPGPKDRIIMEVTLNKEPGVGLGIGACCLTLENSAPGIYIHSLAPGSVAKMDGRLSRGDQLLE 787

  Fly   622 VDQHPVQHFNVD---ALLKEEG---------RSQNP------------------SHSS------- 649
            ||...::|..:.   |:|.|.|         |..||                  ||||
Zfish   788 VDSVSLRHAALSEAYAILSECGPGPVSLIISRHPNPKVSEQEMDEVITRSTHRDSHSSHTLGLPS 852

  Fly   650 -SDFTTL-------------TIKRIVLPDF----------LPMSSPIYSNCPASGINLGMGMGVS 690
             |...|:             |:||.:.|..          |.....::.....|.::..|.||
Zfish   853 KSPSPTVKVKQGEGNPALSWTMKRFLEPASRQGSLSSEAELSQYFTVHDVPSQSSLSETMAMG-- 915

  Fly   691 TSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGS---------- 745
             |:|.|:..|:     :..:....:|..|||..:|     |.|.:      ||||
Zfish   916 -SSDDDMLHSS-----RSCNTSMEESAAPQPHVYR-----DGSYR------GSGSSPTTPECCKA 963

  Fly   746 NGGN----QAANSWSTGVNSRSYVAPPNTQS---------------------------------- 772
            :||.    :.|...|.|.:..|..:|...|.
Zfish   964 SGGTGRTAETAQQASVGSSPSSVRSPLLRQRRVICYEDEPSGDETGLEDDNGPFRRLLRGVSDGH 1028

  Fly   773 ----------LTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSS 827
                      :.|...|.:||.:.   |.|.:|..|.:.|       ...|||:..|...::|.|
Zfish  1029 QHQEEDSGIVIATSSLEVDDESQD---GSESHRQISSEPT-------TPFYGSSIESEEGTTGLS 1083

  Fly   828 --------LHQIIFT---VRLEP------------------------------------KGGLLG 845
                    :|.:..|   |:.||                                    ||....
Zfish  1084 SAESPFMPIHCVEATNLGVKKEPHREGQEVKRSPKLEHKAVTRVKSMMSIECPNPPQRTKGEDPA 1148

  Fly   846 ITLAGSEDITKSIT--------------------------------------------------I 860
            :..|....:|::.|                                                  :
Zfish  1149 LFPANPAQVTQNCTRPPCRMMHCKKGESSELAGVCTIETIVLQRGETESFGLDLEIKSAPLKVLV 1213

  Fly   861 SGLVEGGIAHK--NGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKIL-------RSH 916
            :||..||:|.:  :|::.:||:::.|.:..|..........|:.||...:.|:|.       |..
Zfish  1214 TGLRPGGVAEREASGKMSIGDEIVTIGDTPVCTSSYQEICDLMHNLPITLTLEIKKPVSAVDRLS 1278

  Fly   917 DLANGSHLPQTQAIYAKVQRRPRSPSAN-TEASKESGSGNANGGGAVNGNS 966
            .|...|....:..:.|.   ||.....| |:.::...|.:||...||..:|
Zfish  1279 SLIMSSGCESSSKLEAS---RPSPEERNHTDTTQIPSSEHANAKQAVTTHS 1326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084	5/16 (31%)
		PDZ_signaling	183..254	CDD:238492	27/92 (29%)
		PDZ_signaling	278..375	CDD:238492	21/111 (19%)
		PDZ	496..>521	CDD:294084	7/24 (29%)
		PDZ_signaling	571..658	CDD:238492	34/141 (24%)
		PDZ_signaling	832..913	CDD:238492	23/171 (13%)
		PDZ_signaling	973..1055	CDD:238492
pdzd2	XP_003198698.3	PDZ_signaling	346..423	CDD:238492	24/79 (30%)
		PDZ_signaling	597..680	CDD:238492	17/100 (17%)
		PDZ_signaling	733..817	CDD:238492	24/83 (29%)
		PDZ_signaling	1185..1268	CDD:238492	14/82 (17%)
		NRIP1_repr_1	1556..>1766	CDD:292315
		PDZ_signaling	2216..2288	CDD:238492
		PDZ_signaling	2345..2427	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910