Protein Alignment Grip and grip2a

DIOPT Version :10

• Sequence 1: NP_572285.2
• Gene: Grip / 50391
• FlyBaseID: FBgn0029830
• Length: 1058
• Species: Drosophila melanogaster
• Sequence 2: NP_001417817.1
• Gene: grip2a / 568084
• ZFINID: ZDB-GENE-081104-132
• Length: 1100
• Species: Danio rerio
• Alignment Length: 1233
• Identity: 326/1233 - (26%)
• Similarity: 470/1233 - (38%)
• Gaps: 472/1233 - (38%)

  Fly    67 SEDSG------LAPE-RGTTYATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGHAA--DFLA 122
            |:.||      ||.| ||.|...: :.:....|.:|.:...|....|.|.:|.|.|.||  |.|.
Zfish    69 SDSSGFTNRCSLADEQRGVTTVEL-IKKEGSSLGLTISGGCDKEGKPRVSNLRPGGLAARSDQLN 132

  Fly   123 PGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVE 187
            .||.:..::||:...|.:.::::||...|.   ..::|:||.||....| |...|.||..::.:|
Zfish   133 VGDYIKSVNGINLSKLRHDEIISMLKNIGE---RVVLEVEYELPPFAPS-NPCSVISKTIEVCLE 193

  Fly   188 RESGCLGLTLRGG--ADY----PLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQ 246
            :|....|..||||  .|:    ||:||:|||.||..:.|.::.|||:|.|:.|::..:..|:|..
Zfish   194 KEGNSFGFVLRGGFHEDWHKARPLVVTYVRPGGPADREGTLRAGDRVLSVNGVAVNRQKHADALT 258

  Fly   247 IIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSST 311
            :|......:.:   .||||:.|:.||:.|.|||.::|.|.....|||.|             |::
Zfish   259 LIMQSSQEAFF---LIEYDIMVMDSVQKSSGPLQVDIARSAGSVLGLSL-------------STS 307

  Fly   312 PSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTS---- 372
            ....:::     :.|..|.|||:|||||||..||.:|:||....||.:..  |...:|.:|
Zfish   308 LYRNKQV-----ITIQKIKPASVADRCGALHAGDILLAIDGMSTEHCSLM--EAQQLLSSSSELT 365

  Fly   373 ----------------------------------------TGRGYTQMQIMPAHALARRG----- 392
                                                    |...::|....|:|.....|
Zfish   366 KLEILPSLHSSQDTVRVQRSCQRQWDSSENYTNALPAFQKTPSAWSQTTPTPSHRSVSSGVSANT 430

  Fly   393 ---HT-TLGSPK-----YSFSTLESRKS----STAGRQRQRFARKSSLPLENPACGTPGSTGGSM 444
               |: ..||..     |..|||.|..|    |...|:.:|...||||.|
Zfish   431 SGFHSYNCGSQSAYPNTYPSSTLPSYPSSPRCSATKRRHRRKEHKSSLSL--------------- 480

  Fly   445 GTGGIHGSSSLGMGLGLCRAESFPVLL--DCSHGAGIILSETVSGSGG-------SGAVAIAQIV 500
                  .||::|.|..:...||..|||  |...|.|:.|      .||       |...||..|.
Zfish   481 ------ASSTVGAGGQVVHLESAEVLLRGDPLTGFGLQL------QGGVFATEPLSAPAAIRFIE 533

  Fly   501 PDSVADRSGCIQAGDRIVAINKMYSLDAA--AMRQLLEGGSSRNGASNGTPANWLELEIEFDMPD 563
            ||:.|:|.|.:|.||||::||.:.:.|..  ...|||     |:.|.    ||.:.||:|||:.:
Zfish   534 PDTPAERCGVLQVGDRILSINGIPTEDGTLEEANQLL-----RDAAL----ANKIALEVEFDVAE 589

  Fly   564 AVVPASGVFSVKLLRAGKCGLGLSVSGSSHGG--LVISDVKMGSPAHRSGSLRSGDILLAVDQHP 626
            :|:|:||.|.|||.:.....||:::|.|...|  |:||:::.||.|||.|:|..||.|||:|
Zfish   590 SVIPSSGTFQVKLPKRRGVELGITISASKKAGKPLIISEIQKGSIAHRIGTLEPGDRLLAID--- 651

  Fly   627 VQHFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVST 691
                ||                          |:             .||
Zfish   652 ----NV--------------------------RL-------------DNC--------------- 658

  Fly   692 STDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWS 756
                                                .|::|.:   .|:...|
Zfish   659 ------------------------------------GMEEAMM---VLQQAEG------------ 672

  Fly   757 TGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSS 821
                           .:...:.::||..:::
Zfish   673 ---------------MVKLRIQKDEDNLDEL---------------------------------- 688

  Fly   822 KSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDE 886
            :||||    :||||.|:..||.||||::|:|:....|.||.|...|:||:.|.:|:||::|||:.
Zfish   689 ESSGS----VIFTVELKRHGGPLGITISGTEEPFNPILISSLTRNGLAHRTGALHIGDRVLAINN 749

  Fly   887 HSVQGMPLSHATSLLQNLGDLVDLKIL---------------------------RSHDLANGSH- 923
            .|::|.|||.|..|||..||.|.|||.                           ||.....|.:
Zfish   750 MSLKGKPLSEAIHLLQTAGDTVTLKIKKRSDPLLDSERGSPSRTASCVSDMEDDRSDSFRRGKYS 814

  Fly   924 --LPQT-----------------------QAIYAK---------------------VQRRPR--- 939
              |.||                       |.:|..                     :.|||.
Zfish   815 DLLRQTTPPSLDSAMDSWDSSALDAGYGSQGVYIHRPSDFTLHPSDWRQTNHRSPLMSRRPAHRP 879

  Fly   940 ------------------SPSA--------------------------------NTEASKESGSG 954
                              ||:.                                ..||:..|||.
Zfish   880 TVYDGRLSEEDWTYSGSVSPACGHNYNSTTDAQENYWSQALQDLETCGQSEILRELEATIMSGST 944

  Fly   955 NANG-------------------GGAVN------GNSGSGKPRVFHVTLYKDKVYDDYGFSVSDG 994
            .:.|                   ..:||      .||.|....:..:.:.||....|:|||||||
Zfish   945 LSLGEDFEKQNESKTKFLELSPENTSVNTPEDLKENSPSVPLELHKICIQKDADSRDFGFSVSDG 1009

  Fly   995 LYERGVFINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQRS 1057
            |.|:||::|.||..||||..| |:|:|||:|||..:|:||||||.||||..||:.:::::.|:
Zfish  1010 LLEKGVYVNMIRPDGPADQAG-LRPYDRILQVNHARTRDFDCCLAVPLITEAGENLQLVISRN 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ_canonical	<96..163	CDD:483948	19/68 (28%)
		PDZ2_GRIP1-2-like	180..265	CDD:467169	30/90 (33%)
		PDZ3_GRIP1-2-like	277..384	CDD:467172	34/150 (23%)
		degP_htrA_DO	<491..659	CDD:273938	60/171 (35%)
		PDZ_canonical	572..>623	CDD:483948	24/52 (46%)
		PDZ6_GRIP1-2-like	830..914	CDD:467171	42/110 (38%)
		PDZ7_GRIP1-2-like	971..1056	CDD:467173	43/84 (51%)
grip2a	NP_001417817.1	PDZ1_GRIP1-2-like	88..170	CDD:467175	22/85 (26%)
		PDZ2_GRIP1-2-like	186..274	CDD:467169	30/90 (33%)
		PDZ3_GRIP1-2-like	286..371	CDD:467172	32/104 (31%)
		PDZ4_GRIP1-2-like	490..590	CDD:467174	40/114 (35%)
		PDZ5_GRIP1-2-like	598..680	CDD:467170	34/208 (16%)
		PDZ6_GRIP1-2-like	693..777	CDD:467171	43/87 (49%)
		PDZ7_GRIP1-2-like	986..1070	CDD:467173	43/84 (51%)