DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and erbin

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_005155633.1 Gene:erbin / 566811 ZFINID:ZDB-GENE-061103-403 Length:1392 Species:Danio rerio


Alignment Length:1171 Identity:206/1171 - (17%)
Similarity:337/1171 - (28%) Gaps:459/1171 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 CVPGKSAALKQDQQQQQQQQQESHNNSFNGHHHPPTDTALAPMLSVDRAMSPAQSEDSGLAPERG 77
            |..||.|          :...::..||  .|::.|.|:  ....|::|.  |.::.|:       
Zfish   550 CTNGKPA----------EMDPKAAMNS--NHNYEPIDS--VDNHSIERI--PLKTSDN------- 591

  Fly    78 TTYATITLPRNALHLAITFAERNDLS-----------YPPVVG-SLNPV------------GHAA 118
                    .|..::...|..:..:||           .||::. |:|..            |..|
Zfish   592 --------MRTMVNHDDTLEDSEELSSEEEEMKIAEMRPPLIEISINQPKVVALSKDKKDDGKDA 648

  Fly   119 DFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQ 183
            |.|        :|  .|:..|||.  |..|:.     |:.:....||...:...||||       
Zfish   649 DSL--------LD--ETVANSNQN--NSNCSS-----PSRMSDSVSLTTDSSQDNSLC------- 689

  Fly   184 ITVERESGCLGLTLRGGADYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIG-KTLAEAQQI 247
             |.||||....:...|..|..|              .::|....||:..|.|... :|:.:.|| 
Zfish   690 -TPERESKMPLIPKNGQEDENL--------------NQLKQMTPLLQNCNGSETSLQTILKNQQ- 738

  Fly   248 IKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTP 312
                         :.|.....:....|||...|..||:.:|:                       
Zfish   739 -------------SYESKSDQMADYSFSMEERLALIEKGINN----------------------- 767

  Fly   313 SSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGY 377
                                         .|.||....|...:.....|||.::...:....:..
Zfish   768 -----------------------------GVTDQYSKWDQINMNVAKLSPDNMLAYEELERTKSP 803

  Fly   378 TQMQIMPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRF-ARKSSLPLENPACGTPGSTG 441
            ...:.|.::..||          .|...||:.......:..:.| :|...:||...:..|..:  
Zfish   804 PAKETMSSNNNAR----------LSLENLENGNQLQKTQSGENFNSRTDQVPLRYESVRTVST-- 856

  Fly   442 GSMGTGGIHGSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVAD 506
                  |::..|.:.:...   .|.......|. .|.::.|::::...|.|.             
Zfish   857 ------GVNALSDMSLSRS---TEELSPEKKCP-PAPVVKSQSIANMDGGGM------------- 898

  Fly   507 RSGCIQAGDRIVAINKMYSLDAAAMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGV 571
                           |:||                               ||.:.|...|     
Zfish   899 ---------------KLYS-------------------------------IEGESPPYEV----- 912

  Fly   572 FSVKLLRAGKCGLGLSVSGSSHGGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALL 636
                     .|....||:|:....:|.|         :|.||.:       ||| :|.:      
Zfish   913 ---------ACASRTSVAGAQGQSIVRS---------KSASLLN-------DQH-MQIY------ 945

  Fly   637 KEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYS-- 699
                    |..|:|....|:..:   |   |:||..|...|....|:....  ||....:|:|  
Zfish   946 --------PGSSASSSDLLSSSK---P---PVSSTRYPAGPPPQYNIQYAS--STVPKDNLWSQR 994

  Fly   700 ------SAYVTAGKYADCVSLKSRT-----PQPDYFRVPSMDDASLQSVQL----------RSGS 743
                  ..|:.........:..:|.     |||.....|...|...:...|          |.||
Zfish   995 TPVPPDQPYMPPQHSLANTNFSNRNNAPPYPQPQQRGPPKTPDMWAKERMLPQVGQRGTLQRQGS 1059

  Fly   744 GSNGGN------------------------------QAANSWSTGVNSRSY-VAPPNTQSLTTEL 777
            ||:|..                              |.:.:....:::|:| :..||.       
Zfish  1060 GSSGNPMCMPDPRRMPGMEGDYMTYRDIHAAGRGPLQMSQALHRPLSARTYSMDGPNA------- 1117

  Fly   778 PEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLE---- 838
            |..:                    :|.|||.|......:.|......||...:....|:.|    
Zfish  1118 PRPQ--------------------SARPPPHEVPERTMSVSDFIYQQGSPSKRSNMRVKSEHSLL 1162

  Fly   839 --PKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGM------PLS 895
              |.||...:.....:.:.:.|....:.:..::.....::.....||..  :|.|.      |..
Zfish  1163 DGPVGGGGRVPADWRDQVMRHIEAKKMEKSTLSRSLATLNGSQSSLAFS--AVDGWQFGAHGPSD 1225

  Fly   896 HATSLLQNLGDLVDLKILRSHDLANGSHLPQTQA---------------------IYAKVQRRPR 939
            ...|.....|..:|  .||...|.||...|..::                     :..||.::|.
Zfish  1226 DVFSPHGQQGYHID--TLRKVPLMNGQMCPPVRSPMSCTQPPMARHPSREQLIDYLMLKVSQQPP 1288

  Fly   940 SPSANTEASKESGSGNANGGGAVNGNSGSGKPRVFHVTLYKD-----KVYDDYGFSVSDGLYER- 998
            .|.                             ||.|.||.::     :...:.|||:|.|:..| 
Zfish  1289 GPQ-----------------------------RVPHETLQQEVHVKIEKNPELGFSISGGIGGRG 1324

  Fly   999 --------GVFINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAAGDKIEMIMQ 1055
                    |:|:.|::|.|||..  ||:|.|:|:|.|.....:.|....|.|:....:.:::|:.
Zfish  1325 NPFRPDDNGIFVTRVQSEGPASK--LLQPGDKILQANGYSFVNIDHGHAVSLLKTFPNTVDLIIV 1387

  Fly  1056 R 1056
            |
Zfish  1388 R 1388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 18/88 (20%)
PDZ_signaling 183..254 CDD:238492 16/71 (23%)
PDZ_signaling 278..375 CDD:238492 11/96 (11%)
PDZ 496..>521 CDD:294084 0/24 (0%)
PDZ_signaling 571..658 CDD:238492 17/86 (20%)
PDZ_signaling 832..913 CDD:238492 14/92 (15%)
PDZ_signaling 973..1055 CDD:238492 28/95 (29%)
erbinXP_005155633.1 LRR_RI 8..267 CDD:238064
leucine-rich repeat 24..47 CDD:275380
LRR_8 46..104 CDD:290566
leucine-rich repeat 48..70 CDD:275380
leucine-rich repeat 71..93 CDD:275380
leucine-rich repeat 94..116 CDD:275380
leucine-rich repeat 117..162 CDD:275380
LRR_8 161..219 CDD:290566
leucine-rich repeat 163..185 CDD:275380
LRR_RI 186..401 CDD:238064
leucine-rich repeat 186..208 CDD:275380
leucine-rich repeat 209..231 CDD:275380
LRR_8 230..288 CDD:290566
leucine-rich repeat 232..254 CDD:275380
leucine-rich repeat 255..275 CDD:275380
leucine-rich repeat 278..300 CDD:275380
leucine-rich repeat 301..323 CDD:275380
leucine-rich repeat 324..346 CDD:275380
LRR_8 345..402 CDD:290566
leucine-rich repeat 347..369 CDD:275380
DUF1421 961..>1152 CDD:284607 39/222 (18%)
PDZ_signaling <1331..1387 CDD:238492 18/57 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23119
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.100

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