DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and PARD3

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_062565.2 Gene:PARD3 / 56288 HGNCID:16051 Length:1356 Species:Homo sapiens


Alignment Length:840 Identity:167/840 - (19%)
Similarity:282/840 - (33%) Gaps:268/840 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 DQQQQQQQQQESHNNSFNGHHHPPTDTALAPMLSVDRAMSPAQSEDSGLAPERGTTYATITLPRN 88
            :::|.:|..|...||.::....|                      ||.....|....|       
Human   362 NKEQYEQLSQSEKNNYYSSRFSP----------------------DSQYIDNRSVNSA------- 397

  Fly    89 ALHLAITFAERNDLSYPPVVGSLNPVGHAADFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSD 153
            .||   |......|::||                     .|||..|.:..|...      :|...
Human   398 GLH---TVQRAPRLNHPP---------------------EQIDSHSRLPHSAHP------SGKPP 432

  Fly   154 ACPAIVEIEYSLPE----CTVSQNSLCVTSKLA-QITVERESGCLGL---------TLRGGADYP 204
            :.||      |.|:    .|||  |...|.|:. ::.::.:.|..||         |:.|.|  |
Human   433 SAPA------SAPQNVFSTTVS--SGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSA--P 487

  Fly   205 LIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVV 269
            :.|.::.|.|...:.||:|.||||:.|:.|.|:||:..|...::: ...:.|..:|.:.......
Human   488 IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLR-STKMEGTVSLLVFRQEDAF 551

  Fly   270 QSVEFSMGPLLIEI--ERPMNDKLGLVLCN------YTAAVPASGSGSS---TPSSGEKIEES-- 321
            ...|.:..|..::|  |....|: .:||..      .|..||.:.|||:   ....|.:.:|:  
Human   552 HPRELNAEPSQMQIPKETKAEDE-DIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHA 615

  Fly   322 -AGVFIASILPASIADRCGALSVGDQVLSID-DTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMP 384
             .|:|:.||:....|.:.|.|.|.||::::: ::::..|  :.|.:.|:                
Human   616 DLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKT--NQDAMETL---------------- 662

  Fly   385 AHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTGGI 449
                 ||..:|.|:.:.....:.:|:.|.....:                 :|||..|       
Human   663 -----RRSMSTEGNKRGMIQLIVARRISKCNELK-----------------SPGSPPG------- 698

  Fly   450 HGSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADR----SGC 510
                           ...|:             ||                  ::.||    |..
Human   699 ---------------PELPI-------------ET------------------ALDDRERRISHS 717

  Fly   511 IQAGDRIVAINKMYSLDAAAMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVK 575
            :.:|  |..:::..|.:||..|.:.|.|..:...:...|.:...: ||.|....:.|        
Human   718 LYSG--IEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVI-IEDDRLPVLPP-------- 771

  Fly   576 LLRAGKCGLGLSVSGSSHG--GLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDAL--- 635
                   .|....|.|||.  |.|.:|....:.|..|.   |.|..|:.|..||..|..:..   
Human   772 -------HLSDQSSSSSHDDVGFVTADAGTWAKAAISD---SADCSLSPDVDPVLAFQREGFGRQ 826

  Fly   636 -LKEEGRSQNPSHSSSDFTTLTIKR---IVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHD 696
             :.|:...|....|..||......:   :.:.|...:::.......:...::|..:|:..|:..:
Human   827 SMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLE 891

  Fly   697 LYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNS 761
            ...:|........|   :....|:|...|                |.|.|...:||       ..
Human   892 SLQTAVAEVTLNGD---IPFHRPRPRIIR----------------GRGCNESFRAA-------ID 930

  Fly   762 RSYVAP---PNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPP---MENKVYGS 815
            :||..|   .:.:.:.|   .|||.:|....|.|     ||. ||...|   :|.::.|:
Human   931 KSYDKPAVDDDDEGMET---LEEDTEESSRSGRE-----SVS-TASDQPSHSLERQMNGN 981

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 11/64 (17%)
PDZ_signaling 183..254 CDD:238492 23/79 (29%)
PDZ_signaling 278..375 CDD:238492 27/111 (24%)
PDZ 496..>521 CDD:294084 5/28 (18%)
PDZ_signaling 571..658 CDD:238492 22/92 (24%)
PDZ_signaling 832..913 CDD:238492
PDZ_signaling 973..1055 CDD:238492
PARD3NP_062565.2 DUF3534 1..146 CDD:288873
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..100
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 154..262
PDZ_signaling 272..347 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..448 14/72 (19%)
PDZ_signaling 465..544 CDD:238492 25/81 (31%)
PDZ_signaling 588..681 CDD:238492 25/115 (22%)
Interaction with PRKCI and PRKCZ. /evidence=ECO:0000250|UniProtKB:Q9Z340 712..936 52/270 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 865..886 2/20 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 932..1025 17/59 (29%)
Interaction with FRMD4A. /evidence=ECO:0000250|UniProtKB:Q99NH2 935..1356 15/56 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1129..1356
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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