DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and grip2b

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_021325304.1 Gene:grip2b / 562290 ZFINID:ZDB-GENE-070705-172 Length:1086 Species:Danio rerio


Alignment Length:1246 Identity:332/1246 - (26%)
Similarity:470/1246 - (37%) Gaps:494/1246 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 PE-RGTTYATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGHAA--DFLAPGDRLHQIDGIST 135
            || ||.|...: :.:....|.:|.:...|....|.|.:|.|.|.||  |.|..||.:..::||:.
Zfish    40 PELRGVTLVEL-IKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDQLNVGDYIKSVNGINL 103

  Fly   136 IGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRGG 200
            ..|.:.:::::|...|.   ..::|:||.||.......| .|.||..:|.:::|....|..:|||
Zfish   104 TKLRHDEIISLLKNVGE---RVVLEVEYELPSAAPDSTS-GVISKTIEICLQKEGNSFGFVMRGG 164

  Fly   201 A--DY----PLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQII-KCGGHVSGYT 258
            |  |:    ||:||||||.||..:.|.:|.|||:|.||.|.|...|.::|..:: :||....   
Zfish   165 AHEDWHKSRPLVVTHVRPGGPADREGTLKSGDRILSVDGVVLHSATHSDALVVLTQCGQEAL--- 226

  Fly   259 NLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAG 323
             ..||||||::.||..:.||||:||.:.....||:.|   |.|:.               .....
Zfish   227 -FQIEYDVSIMDSVTNASGPLLVEIAKAPGASLGVTL---TTALH---------------RNKQA 272

  Fly   324 VFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPAHAL 388
            :.|..|.|.|:.||.|||.|||.:||||.|..||.:..  |...:|.:::.:  |:::|:|||..
Zfish   273 IVIDKIKPGSVVDRSGALHVGDHILSIDGTSTEHCSLL--EATQLLASTSDQ--TKLEILPAHQT 333

  Fly   389 ------------------------------ARRGH------------------------------ 393
                                          ...||                              
Zfish   334 RLPGKPQDTVKVQKSDHPHCWDPCVNYCHSQHPGHCKTSTWTSASSNPSSSQDYCKSVVCSNFSP 398

  Fly   394 ---TTLGSPKYSFSTL-------ESRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTGG 448
               ||.|......|||       ..|.|....|||::..:.||:.|                   
Zfish   399 GSTTTSGMTSQGSSTLPRAAPPMSPRNSMLKRRQRKKEHKSSSVSL------------------- 444

  Fly   449 IHGSSSLGMGLGLCRAESFPVLL--DCSHG------AGIILSETVSGSGGSGAVAIAQIVPDSVA 505
              .|||:|.|..:...||..|.|  |..:|      .||..:||:     |....|..|.|||.|
Zfish   445 --ASSSVGPGGQIVHTESSEVTLRGDPLNGFGVQLQGGIFATETL-----SAPPLIRFIEPDSSA 502

  Fly   506 DRSGCIQAGDRIVAINKMYSLDAA--AMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPA 568
            :|.|.:|.|||:::||.:.:.|..  ...|||     |:.|.    ||.:.||||||:.::|||:
Zfish   503 ERCGLLQVGDRVLSINGIPTEDGTLEEANQLL-----RDAAL----ANKVSLEIEFDVAESVVPS 558

  Fly   569 SGVFSVKLLRAGKCGLGLSVSGSSHGG--LVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFN 631
            ||.|.|||.:.....||:::|.|...|  |:|||:|.||.|||:|:|..||.|||:|...::   
Zfish   559 SGTFHVKLQKKRGVELGITISASKKPGEPLIISDIKKGSMAHRTGTLEPGDKLLAIDNIRLE--- 620

  Fly   632 VDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHD 696
                                                       ||                    
Zfish   621 -------------------------------------------NC-------------------- 622

  Fly   697 LYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNS 761
                                           ||:||                             
Zfish   623 -------------------------------SMEDA----------------------------- 627

  Fly   762 RSYVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKSSGS 826
             :.:...:...:..::.::||.                                  |...:||||
Zfish   628 -AQILQQSEDLVKLKIRKDEDN----------------------------------SDEQESSGS 657

  Fly   827 SLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQG 891
                ||:||.|:..||.||||::|:|:....|.||||.:.|:|.:.|.|||||::|||:..|::|
Zfish   658 ----IIYTVELKRYGGPLGITISGTEEPFDPIIISGLTKRGLAERTGAIHVGDRILAINSVSLKG 718

  Fly   892 MPLSHATSLLQNLGDLVDLKIL----------RSHDLAN-------------------------- 920
            .|||.|..|||..|:.|.|||.          :.:||.|                          
Zfish   719 KPLSEAIHLLQMAGETVTLKIKKQADSPDEKNKENDLENDLSDNEDEMTDSQKTNKLSDIYSTTI 783

  Fly   921 ----------------------GSHLPQTQAI------YAKVQRRPRSP---------------- 941
                                  |:.:.|...|      :...::|..:|                
Zfish   784 PSVDSAMESWDGSGIDAGYSSQGAFIHQAAGIALHPHEWRNTKQRNSTPPPTRRKNYPFSDGGFS 848

  Fly   942 ----------SANT---------------------------------EASKESGSGNANG--GG- 960
                      |:.|                                 |||..:||..:.|  || 
Zfish   849 EDDWDKAAGYSSQTHADALLMEQEDSFWCQALEDLETCGQSELLREIEASIMTGSALSLGVEGGK 913

  Fly   961 ----AVNG-------------NSGSGK--------------------------PRVFH-VTLYKD 981
                .||.             |....|                          |...| ||:.||
Zfish   914 THVDPVNQPHLSPLRKSPHLFNETKNKSTLRMSEKTWESRRIKEEIQDILSPTPLELHKVTVMKD 978

  Fly   982 KVYDDYGFSVSDGLYERGVFINRIRSGGPADMCGLLKPFDRIMQVNEMKTQDFDCCLTVPLIAAA 1046
            ...||:|||||||..|:||::|.||..||||..| |||:|||:|||.::|:||||||.||||..|
Zfish   979 PESDDFGFSVSDGFLEKGVYVNMIRPEGPADRAG-LKPYDRILQVNHVRTRDFDCCLAVPLITEA 1042

  Fly  1047 GDKIEMIMQRS 1057
            |||:|:::.|:
Zfish  1043 GDKLELVISRN 1053

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 17/66 (26%)
PDZ_signaling 183..254 CDD:238492 32/77 (42%)
PDZ_signaling 278..375 CDD:238492 31/96 (32%)
PDZ 496..>521 CDD:294084 12/24 (50%)
PDZ_signaling 571..658 CDD:238492 27/88 (31%)
PDZ_signaling 832..913 CDD:238492 41/80 (51%)
PDZ_signaling 973..1055 CDD:238492 50/82 (61%)
grip2bXP_021325304.1 PDZ_signaling 45..127 CDD:238492 21/85 (25%)
PDZ 144..232 CDD:214570 35/91 (38%)
PDZ_signaling 245..328 CDD:238492 32/104 (31%)
PDZ_signaling 462..548 CDD:238492 33/99 (33%)
PDZ_signaling 561..643 CDD:238492 33/208 (16%)
PDZ_signaling 659..740 CDD:238492 41/80 (51%)
Peptidase_S41 672..>841 CDD:321971 43/168 (26%)
PDZ_signaling 970..1050 CDD:238492 50/80 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 108 1.000 Domainoid score I6371
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 325 1.000 Inparanoid score I2466
OMA 1 1.010 - - QHG46788
OrthoDB 1 1.010 - - D42090at33208
OrthoFinder 1 1.000 - - FOG0003379
OrthoInspector 1 1.000 - - otm25993
orthoMCL 1 0.900 - - OOG6_103747
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5842
SonicParanoid 1 1.000 - - X2278
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.910

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