DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip and grid2ipb

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_009304908.1	Gene:	grid2ipb / 559717	ZFINID:	ZDB-GENE-040724-161	Length:	1383	Species:	Danio rerio

Alignment Length:	903	Identity:	168/903 - (18%)
Similarity:	293/903 - (32%)	Gaps:	345/903 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 LAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQIT 185
            |.|||::.:|:|.:...||.|:|:            |:.:.:.::|.      |:.|.|::.|:.
Zfish    38 LQPGDQVLEIEGQNVSSLSAQEVI------------ALAQSQRNIPP------SIGVVSRIQQMD 84

  Fly   186 V-ERESGCLGLTLRGGADYPLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSL----IGKTLAEAQ 245
            : ....|..|.|:.|  |.||:|....|..|..::| ::.||.::.|:.:.:    :...|.:|.
Zfish    85 ITPGPDGRFGFTIVG--DCPLLVEDCSPCSPAGRSG-LRAGDYVMEVNGIPVKHHEMAAALIKAS 146

  Fly   246 Q--IIKCG------------GHVSGYTNLT-----------IEYDVSVVQSVEFSMGPLLIEIER 285
            |  .::.|            |.:.|....|           :|::..|.:         ::..|.
Zfish   147 QGRTLRLGVLCMGSRQKRSSGSLEGLQKDTDGMRQDRKHKALEFNRRVEE---------ILRNEP 202

  Fly   286 PMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSI 350
            .:.:||..||..:.|.              .|::     ::||:||       ..|:..:|...|
Zfish   203 EVKEKLFAVLKQFAAE--------------RKVD-----WLASVLP-------DILTTEEQQQLI 241

  Fly   351 DDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPAHALARR--GHTTLGSPKYSFSTLESRKSST 413
            .:..|    |.|.:.....|.:.           :.:|..|  ...:||.|:   :.|...:|..
Zfish   242 SNIRI----FIPKKHRQRFDEAV-----------SQSLINRMCRSKSLGEPQ---NRLRRSRSQD 288

  Fly   414 AGRQRQRFARKSSLPLE---------------NPACGTPGSTGGSMGTGGIH-GSSSLGMGLGLC 462
            ...:.|...|.||:|.:               |....|...:|.:..|..:: |..|.|..|
Zfish   289 HHERPQGSKRASSVPRDTGDEPAQNDRTLRKSNTMIPTQYVSGVNQRTIRVYRGKKSFGFTL--- 350

  Fly   463 RAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLD 527
                                      .|...|.|..::|.|.|:..| ::.||||:.:|
Zfish   351 --------------------------RGHAPVWIDSVMPGSPAEACG-LKTGDRILFLN------ 382

  Fly   528 AAAMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSS 592
                                                                     ||.:...|
Zfish   383 ---------------------------------------------------------GLDMRNCS 390

  Fly   593 HGGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKE---EGRSQNPSHSSSDFTT 654
            |       .|:.|....||::.|    |.|::.||.:...|:..:|   ..||::|:.||..:
Zfish   391 H-------EKVVSMLQGSGAMPS----LVVEEGPVDYPQSDSEPEETPSAPRSRSPALSSLQW-- 442

  Fly   655 LTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKS--- 716
                   :.:.||.|..::            |...|...:|.|     ....:|..|.:|::
Zfish   443 -------VAEILPPSIRVH------------GRTFSQQLEHLL-----TLQERYTICKALETFFQ 483

  Fly   717 ----RTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTEL 777
                .|...|.|  |.:|..:.|.:                 |       .::    .|.||.|.
Zfish   484 HRNVDTLIVDVF--PVLDTPAKQLI-----------------W-------QFI----YQLLTYEE 518

  Fly   778 PEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGG 842
            .|....:...:.|::          :..|.:..:.:  ..|||.:.||:| |:  .|||......
Zfish   519 QEHCKTKIARFLGFK----------SAEPEVGAETH--RRSSSMRVSGTS-HK--NTVRERSSDD 568

  Fly   843 LLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMP-LSHATSLLQNLGD 906
            .:..|..|....|..:|                  .::....|..|....| |||.|.:...||:
Zfish   569 CIIGTHLGMGTFTDPVT------------------PEERQCGDGTSFPESPDLSHMTGVYTELGN 615

  Fly   907 LVDLK---ILRSHD--LANGSHLPQTQAIYAKVQRRPRSPSANTEASKESGSGNANGG 959
            :..:|   .|:||.  .|.|..|.::              :..|::...|.:||...|
Zfish   616 VYPVKSSQSLQSHSSPRAAGMGLAES--------------NTYTQSFTHSTAGNRKSG 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084	10/25 (40%)
		PDZ_signaling	183..254	CDD:238492	20/89 (22%)
		PDZ_signaling	278..375	CDD:238492	18/96 (19%)
		PDZ	496..>521	CDD:294084	9/24 (38%)
		PDZ_signaling	571..658	CDD:238492	20/89 (22%)
		PDZ_signaling	832..913	CDD:238492	17/84 (20%)
		PDZ_signaling	973..1055	CDD:238492
grid2ipb	XP_009304908.1	PDZ_signaling	9..69	CDD:238492	11/42 (26%)
		PDZ_signaling	80..156	CDD:238492	19/78 (24%)
		HN_L-delphilin-R1_like	183..262	CDD:259820	20/128 (16%)
		PDZ_signaling	335..410	CDD:238492	27/178 (15%)
		HN_L-delphilin-R2_like	451..530	CDD:259821	19/125 (15%)
		FH2	995..1360	CDD:280362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900