Protein Alignment Grip and grip1

DIOPT Version :10

• Sequence 1: NP_572285.2
• Gene: Grip / 50391
• FlyBaseID: FBgn0029830
• Length: 1058
• Species: Drosophila melanogaster
• Sequence 2: XP_009298419.1
• Gene: grip1 / 558006
• ZFINID: ZDB-GENE-041210-125
• Length: 1191
• Species: Danio rerio
• Alignment Length: 1326
• Identity: 332/1326 - (25%)
• Similarity: 497/1326 - (37%)
• Gaps: 538/1326 - (40%)

  Fly    36 HNNSFNGHHHP--PTDTALAPMLSVDRAMSPAQSEDSG---LAPERGTTYATITLPRNALHLAIT 95
            |...:..|.:|  |.|.|||    :.|...|.:.:.:.   |..:.|||            |.:|
Zfish    45 HEGPYTKHSNPSRPPDGALA----IRRQSIPDEFKGTSTVELIKKEGTT------------LGLT 93

  Fly    96 FAERNDLSYPPVVGSLNPVGHAA--DFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAI 158
            .:...|....|.|.:|...|.||  |.|..||.:..::||:.....:.:::::|...|.   ..:
Zfish    94 VSGGIDKDGKPRVSNLRQGGIAARSDQLNVGDYIKSVNGINLTKFRHDEIISLLKNVGE---RVV 155

  Fly   159 VEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRGGA------DYPLIVTHVRPHGPVY 217
            :|:||.||..:|..:.  |..|..::|:.:|....|..:||||      ..|:.:|.:||.||..
Zfish   156 LEVEYELPPVSVQGSG--VMFKNVEVTLHKEGNTFGFVIRGGAHEDRNKSRPVTITTIRPGGPAD 218

  Fly   218 KTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIK-CGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLI 281
            :.|.||||||||.:|.:.|.|.:.|||..|:| ||...:    |.|||||||:.||..:.||||:
Zfish   219 REGTIKPGDRLLSIDGIRLHGASHAEAMSILKQCGQEAT----LLIEYDVSVMDSVATASGPLLV 279

  Fly   282 EIERPMNDKLGLVL-----CNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGAL 341
            |:.:.|...|||.|     ||...                       :.|..:.|||||||||||
Zfish   280 EVAKSMGSSLGLALSTSMYCNKQV-----------------------IIIDKVKPASIADRCGAL 321

  Fly   342 SVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPAH--ALARRG------------ 392
            ..||.:||:|.|.:|:...:  |...:|  ::...:.:|:|:|.|  .||.:|
Zfish   322 HAGDHILSVDGTSMEYCTLA--EATQLL--ASASEHVKMEILPHHQTRLALKGPEHVKVQRSTRP 382

  Fly   393 -------------------------------------HTTLGS-------PKYSFSTLE------ 407
                                                 :..|||       ..||.|:|.
Zfish   383 LPWESGTNNNSNFLPYQHYNTYHPDQSHSQAKKTSPSNPPLGSSFSPTSMSAYSLSSLNMNTLPR 447

  Fly   408 -----SRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTGGIH---------GSSSLGMG 458
                 |.:.:...|:.::...|||:.|.:...|..|..        :|         ..|.:|.|
Zfish   448 TMYPTSPRGTMMRRKLKKKDYKSSMSLASSTVGLAGQV--------VHTETTEVTLISDSIMGFG 504

  Fly   459 LGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKM 523
            :.|              ..|:..:||:     |....||.|.|||.|:|.|.:|.||||::||.:
Zfish   505 IQL--------------QGGVFATETL-----SSPPLIAYIDPDSPAERCGILQIGDRILSINGI 550

  Fly   524 YSLDAA--AMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGL 586
            .:.|:.  ...|||...|..:..:         ||||||:.::|:|:||.|.|||.:.....||:
Zfish   551 PTEDSTLEETNQLLRDSSITSKVT---------LEIEFDVAESVIPSSGTFHVKLPKKPGVELGI 606

  Fly   587 SVSGSSH----GGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSH 647
            ::|..|.    ..|:|||:|.||.|||:|:|..||.|||:|...:.:.:::..::
Zfish   607 TISSPSSRKPGDALIISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQ---------- 661

  Fly   648 SSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCV 712
                                    |...|                                .|.|
Zfish   662 ------------------------ILQQC--------------------------------EDLV 670

  Fly   713 SLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTEL 777
            .||.|..:         |::.:    ||:||...             |:|..:|.
Zfish   671 KLKIRKDE---------DNSGV----LRAGSVDR-------------NARVLLAC---------- 699

  Fly   778 PEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGG 842
              ..||||                                     :||:    ||:||.|:..||
Zfish   700 --VADEQE-------------------------------------TSGA----IIYTVELKRYGG 721

  Fly   843 LLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDL 907
            .||||::|:|:....|.||.|.:||:|.:.|.||:||::|||:.:|::|.|||.|..|||..|:.
Zfish   722 PLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSNSLKGKPLSEAIHLLQMAGES 786

  Fly   908 VDLKILRSHDLA-------------------NGSHLPQTQAIY---------------------- 931
            |.|||.:..:|.                   :|....:...||
Zfish   787 VTLKIKKQGELPSPKPPSVTGRLNNLSDLEDDGQKAGKLSDIYSTTIPSVDSAVESWDGSAIDAT 851

  Fly   932 -----------------------AKVQR---------------------------RPRSPSANT- 945
                                   ||..|                           ||.:..|:|
Zfish   852 FSTQAPTGFQASGYSFHSHEWRNAKPSRGSLSPVNSSRQRNNILPDFGIGVDDWDRPSASGASTL 916

  Fly   946 ---------------------------------EASKESG------------------------- 952
                                             |...:||
Zfish   917 PTGLISDSRFTVGHDGTEPDQEENFWSQALEDLETCGQSGILRELEDKPDRLLNKRNLAILATIM 981

  Fly   953 SGNA-------------NGGGAVNGNSGSGKPR-------------------------------- 972
            ||::             .|..|.....||.||:
Zfish   982 SGSSLSLNHDPAPTRSHLGRQASFQERGSNKPQYSQANRSNTLPTDVGRKAFAMRRMKQEIKDIM 1046

  Fly   973 ------VFHVTLYKDKVYDDYGFSVSDGLYERGVFINRIRSGGPADMCGLLKPFDRIMQVNEMKT 1031
                  :..|:|.||...:|:|||||||:.|:||::|.||.||||::.| |||:||::|:|.::|
Zfish  1047 SPTPVELHKVSLLKDSDLEDFGFSVSDGVLEKGVYVNNIRPGGPAEIGG-LKPYDRLLQINHVRT 1110

  Fly  1032 QDFDCCLTVPLIAAAGDKIEMIMQRS 1057
            :||||||.|||||.:|:|:::::.|:
Zfish  1111 RDFDCCLVVPLIAESGNKLDLVISRN 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ_canonical	<96..163	CDD:483948	16/68 (24%)
		PDZ2_GRIP1-2-like	180..265	CDD:467169	36/91 (40%)
		PDZ3_GRIP1-2-like	277..384	CDD:467172	35/111 (32%)
		degP_htrA_DO	<491..659	CDD:273938	58/173 (34%)
		PDZ_canonical	572..>623	CDD:483948	25/54 (46%)
		PDZ6_GRIP1-2-like	830..914	CDD:467171	42/83 (51%)
		PDZ7_GRIP1-2-like	971..1056	CDD:467173	45/122 (37%)
grip1	XP_009298419.1	PDZ1_GRIP1-2-like	78..160	CDD:467175	22/96 (23%)
		PDZ2_GRIP1-2-like	175..263	CDD:467169	36/91 (40%)
		PDZ3_GRIP1-2-like	275..360	CDD:467172	35/111 (32%)
		PDZ4_GRIP1-2-like	484..584	CDD:467174	36/135 (27%)
		PDZ5_GRIP1-2-like	592..676	CDD:467170	32/149 (21%)
		PDZ6_GRIP1-2-like	709..793	CDD:467171	42/87 (48%)
		PDZ7_GRIP1-2-like	1051..1135	CDD:467173	44/84 (52%)