DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip and grip1

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_009298419.1	Gene:	grip1 / 558006	ZFINID:	ZDB-GENE-041210-125	Length:	1191	Species:	Danio rerio

Alignment Length:	1326	Identity:	332/1326 - (25%)
Similarity:	497/1326 - (37%)	Gaps:	538/1326 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 HNNSFNGHHHP--PTDTALAPMLSVDRAMSPAQSEDSG---LAPERGTTYATITLPRNALHLAIT 95
            |...:..|.:|  |.|.|||    :.|...|.:.:.:.   |..:.|||            |.:|
Zfish    45 HEGPYTKHSNPSRPPDGALA----IRRQSIPDEFKGTSTVELIKKEGTT------------LGLT 93

  Fly    96 FAERNDLSYPPVVGSLNPVGHAA--DFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAI 158
            .:...|....|.|.:|...|.||  |.|..||.:..::||:.....:.:::::|...|.   ..:
Zfish    94 VSGGIDKDGKPRVSNLRQGGIAARSDQLNVGDYIKSVNGINLTKFRHDEIISLLKNVGE---RVV 155

  Fly   159 VEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRGGA------DYPLIVTHVRPHGPVY 217
            :|:||.||..:|..:.  |..|..::|:.:|....|..:||||      ..|:.:|.:||.||..
Zfish   156 LEVEYELPPVSVQGSG--VMFKNVEVTLHKEGNTFGFVIRGGAHEDRNKSRPVTITTIRPGGPAD 218

  Fly   218 KTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIK-CGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLI 281
            :.|.||||||||.:|.:.|.|.:.|||..|:| ||...:    |.|||||||:.||..:.||||:
Zfish   219 REGTIKPGDRLLSIDGIRLHGASHAEAMSILKQCGQEAT----LLIEYDVSVMDSVATASGPLLV 279

  Fly   282 EIERPMNDKLGLVL-----CNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGAL 341
            |:.:.|...|||.|     ||...                       :.|..:.|||||||||||
Zfish   280 EVAKSMGSSLGLALSTSMYCNKQV-----------------------IIIDKVKPASIADRCGAL 321

  Fly   342 SVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPAH--ALARRG------------ 392
            ..||.:||:|.|.:|:...:  |...:|  ::...:.:|:|:|.|  .||.:|
Zfish   322 HAGDHILSVDGTSMEYCTLA--EATQLL--ASASEHVKMEILPHHQTRLALKGPEHVKVQRSTRP 382

  Fly   393 -------------------------------------HTTLGS-------PKYSFSTLE------ 407
                                                 :..|||       ..||.|:|.
Zfish   383 LPWESGTNNNSNFLPYQHYNTYHPDQSHSQAKKTSPSNPPLGSSFSPTSMSAYSLSSLNMNTLPR 447

  Fly   408 -----SRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSMGTGGIH---------GSSSLGMG 458
                 |.:.:...|:.::...|||:.|.:...|..|..        :|         ..|.:|.|
Zfish   448 TMYPTSPRGTMMRRKLKKKDYKSSMSLASSTVGLAGQV--------VHTETTEVTLISDSIMGFG 504

  Fly   459 LGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKM 523
            :.|              ..|:..:||:     |....||.|.|||.|:|.|.:|.||||::||.:
Zfish   505 IQL--------------QGGVFATETL-----SSPPLIAYIDPDSPAERCGILQIGDRILSINGI 550

  Fly   524 YSLDAA--AMRQLLEGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRAGKCGLGL 586
            .:.|:.  ...|||...|..:..:         ||||||:.::|:|:||.|.|||.:.....||:
Zfish   551 PTEDSTLEETNQLLRDSSITSKVT---------LEIEFDVAESVIPSSGTFHVKLPKKPGVELGI 606

  Fly   587 SVSGSSH----GGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQNPSH 647
            ::|..|.    ..|:|||:|.||.|||:|:|..||.|||:|...:.:.:::..::
Zfish   607 TISSPSSRKPGDALIISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQ---------- 661

  Fly   648 SSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCV 712
                                    |...|                                .|.|
Zfish   662 ------------------------ILQQC--------------------------------EDLV 670

  Fly   713 SLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAPPNTQSLTTEL 777
            .||.|..:         |::.:    ||:||...             |:|..:|.
Zfish   671 KLKIRKDE---------DNSGV----LRAGSVDR-------------NARVLLAC---------- 699

  Fly   778 PEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSSLHQIIFTVRLEPKGG 842
              ..||||                                     :||:    ||:||.|:..||
Zfish   700 --VADEQE-------------------------------------TSGA----IIYTVELKRYGG 721

  Fly   843 LLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDL 907
            .||||::|:|:....|.||.|.:||:|.:.|.||:||::|||:.:|::|.|||.|..|||..|:.
Zfish   722 PLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSNSLKGKPLSEAIHLLQMAGES 786

  Fly   908 VDLKILRSHDLA-------------------NGSHLPQTQAIY---------------------- 931
            |.|||.:..:|.                   :|....:...||
Zfish   787 VTLKIKKQGELPSPKPPSVTGRLNNLSDLEDDGQKAGKLSDIYSTTIPSVDSAVESWDGSAIDAT 851

  Fly   932 -----------------------AKVQR---------------------------RPRSPSANT- 945
                                   ||..|                           ||.:..|:|
Zfish   852 FSTQAPTGFQASGYSFHSHEWRNAKPSRGSLSPVNSSRQRNNILPDFGIGVDDWDRPSASGASTL 916

  Fly   946 ---------------------------------EASKESG------------------------- 952
                                             |...:||
Zfish   917 PTGLISDSRFTVGHDGTEPDQEENFWSQALEDLETCGQSGILRELEDKPDRLLNKRNLAILATIM 981

  Fly   953 SGNA-------------NGGGAVNGNSGSGKPR-------------------------------- 972
            ||::             .|..|.....||.||:
Zfish   982 SGSSLSLNHDPAPTRSHLGRQASFQERGSNKPQYSQANRSNTLPTDVGRKAFAMRRMKQEIKDIM 1046

  Fly   973 ------VFHVTLYKDKVYDDYGFSVSDGLYERGVFINRIRSGGPADMCGLLKPFDRIMQVNEMKT 1031
                  :..|:|.||...:|:|||||||:.|:||::|.||.||||::.| |||:||::|:|.::|
Zfish  1047 SPTPVELHKVSLLKDSDLEDFGFSVSDGVLEKGVYVNNIRPGGPAEIGG-LKPYDRLLQINHVRT 1110

  Fly  1032 QDFDCCLTVPLIAAAGDKIEMIMQRS 1057
            :||||||.|||||.:|:|:::::.|:
Zfish  1111 RDFDCCLVVPLIAESGNKLDLVISRN 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084	15/66 (23%)
		PDZ_signaling	183..254	CDD:238492	32/77 (42%)
		PDZ_signaling	278..375	CDD:238492	32/101 (32%)
		PDZ	496..>521	CDD:294084	14/24 (58%)
		PDZ_signaling	571..658	CDD:238492	26/90 (29%)
		PDZ_signaling	832..913	CDD:238492	40/80 (50%)
		PDZ_signaling	973..1055	CDD:238492	44/81 (54%)
grip1	XP_009298419.1	PDZ_signaling	79..159	CDD:238492	22/94 (23%)
		PDZ_signaling	178..261	CDD:238492	33/86 (38%)
		PDZ_signaling	276..359	CDD:238492	33/109 (30%)
		PDZ_signaling	490..578	CDD:238492	31/115 (27%)
		PDZ_signaling	591..675	CDD:238492	32/149 (21%)
		PDZ_signaling	711..792	CDD:238492	40/80 (50%)
		PDZ_signaling	1053..1133	CDD:238492	44/80 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6371
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2466
OMA	1	1.010	-	-		QHG46788
OrthoDB	1	1.010	-	-		D42090at33208
OrthoFinder	1	1.000	-	-		FOG0003379
OrthoInspector	1	1.000	-	-		otm25993
orthoMCL	1	0.900	-	-		OOG6_103747
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5842
SonicParanoid	1	1.000	-	-		X2278
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770