DRSC/TRiP Functional Genomics Resources

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Protein Alignment Grip and PDZK1

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_024303384.1 Gene:PDZK1 / 5174 HGNCID:8821 Length:539 Species:Homo sapiens


Alignment Length:673 Identity:131/673 - (19%)
Similarity:231/673 - (34%) Gaps:226/673 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   319 EESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILD--TSTGRGYTQMQ 381
            :::.|..:..:...|.|::.| |..||:||.|:...::     .:|.|.::|  ..:|...|.: 
Human    48 KDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVD-----KEEHMQVVDLVRKSGNSVTLL- 105

  Fly   382 IMPAHALARRGHTTLGSPKY--SFSTLESRKSSTAGRQRQRFARKSSLPLENPACGTPGSTGGSM 444
                         .|....|  :..|....|.....::.|..:.....|:.|             
Human   106 -------------VLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMN------------- 144

  Fly   445 GTGGIHGSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSG 509
              ||:...:.    ..||    :.|....|:|..:   :||.|..|   |.:..|.|..||.|:|
Human   145 --GGVQTWTQ----PRLC----YLVKEGGSYGFSL---KTVQGKKG---VYMTDITPQGVAMRAG 193

  Fly   510 CIQAGDRIVAINKMYSLDAAAMRQLLEGGSSRNGA-------SNGTPANWLELEIEFDMPDAVVP 567
             :.|.|.::.:|. .:::.|:..:::| ...::|:       ...|....:|.:|:|....|   
Human   194 -VLADDHLIEVNG-ENVEDASHEEVVE-KVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETA--- 252

  Fly   568 ASGVFSVKLL---------RAGKCGLGLSV-SGSSHGGLVISDVKMGSPAHRSGSLRSGDILLAV 622
                 |:|||         :.|..|.|..: :||...|.:|.|:..||||..:| |::.|:::||
Human   253 -----SLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAG-LKNNDLVVAV 311

  Fly   623 DQHPVQ---HFNVDALLKEEGRSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLG 684
            :...|:   |.:|..::::.|          |.|:|.:                           
Human   312 NGESVETLDHDSVVEMIRKGG----------DQTSLLV--------------------------- 339

  Fly   685 MGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGN 749
                |...|| ::|..|:.:...|                         .||.:|.:||...   
Human   340 ----VDKETD-NMYRLAHFSPFLY-------------------------YQSQELPNGSVKE--- 371

  Fly   750 QAANSWSTGVNSRSYVAP-PNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVY 813
                            || |...||....|.:..|:....|  :|.|.|.         .||. |
Human   372 ----------------APAPTPTSLEVSSPPDTTEEVDHKP--KLCRLAK---------GENG-Y 408

  Fly   814 GSAASSSSKSSGSSLHQIIFTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVG 878
            |...::.....||.:.::       .|||  ...|||.||....|.::|            ::|.
Human   409 GFHLNAIRGLPGSFIKEV-------QKGG--PADLAGLEDEDVIIEVNG------------VNVL 452

  Fly   879 DQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKIL--RSHDLANGSHLPQTQAIYAKVQRRPRSP 941
            |:            |.......:|:.|..|.|.:.  :::|......:|...::...:...|.|.
Human   453 DE------------PYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSK 505

  Fly   942 SA-------NTEASKESGSGNAN 957
            ..       ::..:||.....|:
Human   506 EGIVVESNHDSHMAKERAHSTAS 528

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084
PDZ_signaling 183..254 CDD:238492
PDZ_signaling 278..375 CDD:238492 13/57 (23%)
PDZ 496..>521 CDD:294084 8/24 (33%)
PDZ_signaling 571..658 CDD:238492 28/99 (28%)
PDZ_signaling 832..913 CDD:238492 17/80 (21%)
PDZ_signaling 973..1055 CDD:238492
PDZK1XP_024303384.1 PDZ_signaling 27..107 CDD:238492 15/78 (19%)
PDZ 152..232 CDD:214570 22/96 (23%)
PDZ_signaling 261..340 CDD:238492 24/120 (20%)
PDZ 395..475 CDD:214570 27/124 (22%)
F1-ATPase_gamma <457..>501 CDD:320933 6/43 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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