DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and dlg2

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:XP_009303676.1 Gene:dlg2 / 497638 ZFINID:ZDB-GENE-050221-3 Length:1083 Species:Danio rerio


Alignment Length:1098 Identity:210/1098 - (19%)
Similarity:359/1098 - (32%) Gaps:380/1098 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 WKSKKPIGGCVPGKSAALKQDQQQQQQQQQESHNNSFNGHHHPPTDTALAPMLSVDRAMSPAQSE 68
            |..:|..|..:|.:......|         ..|:..:.....||.:.:...:.:..||.......
Zfish   153 WVRQKHGGRAIPNRLCLSTTD---------SPHSYRYQDDDSPPPEHSFPRLTNEVRAPELVHVS 208

  Fly    69 DSGLAPERG----TTYATITLPRNALHLAITFAERNDLSYPPVVGSLNPVGHAADFLA-PGDRLH 128
            :..|:....    .:::.|:..:.||      ..|.||:||.|.        ||::|| |...:.
Zfish   209 EKNLSEIENVHGYVSHSHISPLKPAL------VTRFDLTYPGVT--------AANYLASPAPIIV 259

  Fly   129 QIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCL 193
            ..|.:.::...|.                 .||||...|                ||:||.:..|
Zfish   260 NTDTLESVPYVNG-----------------TEIEYEFEE----------------ITLERGNSGL 291

  Fly   194 GLTLRGGADYP-------LIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIKCG 251
            |.::.||.|.|       :.:|.:.|.|...:.||::..|.:|||:...:...:.::|.:.:|..
Zfish   292 GFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNESDVSEVSHSKAVEALKAA 356

  Fly   252 GHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDK------------LGLVLCNYTAAVPA 304
            |              |:|:        |.:...|||.:.            ||..:        |
Zfish   357 G--------------SIVR--------LYVRRRRPMLETVTEIKLIKGPKGLGFSI--------A 391

  Fly   305 SGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTIL 369
            .|.|:      :.|.....:::..|:....|.:.|.|.|||::|.:::..:|..  :.:|.:.||
Zfish   392 GGVGN------QHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEV--THEEAVAIL 448

  Fly   370 DTSTGRGYTQMQIMPAHALARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPLENPAC 434
            ..::...|.:                :|.|                         :|:.|.:| .
Zfish   449 KNTSDVVYLK----------------VGKP-------------------------TSVYLSDP-Y 471

  Fly   435 GTPGSTGGSMGTGGIHGSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQI 499
            |.|                                  |.:|.....:...:|..|.:|.:.....
Zfish   472 GPP----------------------------------DITHSFSPAMENHISSPGNNGTLEYKSS 502

  Fly   500 VPDSVADRSGCIQ---AGDRIVAINKM--------YSLDAAAMRQLLEGG--------------- 538
            :|.....|...:.   .|:.  .||::        .|||.      :||.               
Zfish   503 LPPISPGRYSPLPKHLLGEE--DINRLDGFSFLRNPSLDE------MEGHRFDSQHFQLRPPEPV 559

  Fly   539 -SSRNGASNGTPANWLELEIEFD-----------------MPDAVV---PASGVFSVKLLRAGKC 582
             |:.|..|:..|:..|...:|||                 :||:.:   |...|     |..|..
Zfish   560 YSTVNKLSDRAPSPRLYSPVEFDKSPMHSIPHFPHYHVGLLPDSEITREPRKIV-----LHKGST 619

  Fly   583 GLGLSVSGSSHG-GLVISDVKMGSPAHRSGSLRSGDILLAV---DQHPVQHFNVDALLKEEGRSQ 643
            |||.::.|...| |:.:|.:..|.||..||.||.||.:|:|   |.....|....|.||..|:  
Zfish   620 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDQILSVNGIDLRGATHEQAAAALKGAGQ-- 682

  Fly   644 NPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASG---------------INLGMGMG---VS 690
                      |:||.....|:.|.:.||..:..|.:.               :|..|..|   :.
Zfish   683 ----------TVTIIAQYRPEELALCSPRRAPPPTAEYGRFEAKIHDLREQMMNHSMSSGSGSLR 737

  Fly   691 TSTDHDLY-----------SSAYVTAG---KYADCVSL-----------KSRTPQ---------P 721
            |:....||           .|...:.|   :|.|.:.:           :..||:         |
Zfish   738 TNQKRSLYVRALFDYERAKDSGLPSQGLSFRYGDILHVINASDDEWWQARRVTPEGDSEEMGVIP 802

  Fly   722 DYFRVPSMDDASLQSVQLRSGSGS--NGGNQAANSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQ 784
            ...||...:.|.|::|:..:..||  :.|:.:.......:.||.:....|..:...:..:.|..|
Zfish   803 SKRRVERKERARLKTVKFNAKPGSLDSKGSFSEKRRKNFIFSRKFPFYKNKDADEQDGSDSERSQ 867

  Fly   785 EQMYPGY------ELNRYASVDCTALPPPMENKV-----------YGSAASSSSKSSGSSLHQII 832
            |::...|      |:| ||..  ..:..||::::           :||....::.|....     
Zfish   868 EELILSYEPVIRQEIN-YARP--VIILGPMKDRINDDLISEFPDKFGSCVPPANSSDQED----- 924

  Fly   833 FTVRLEPK-----GGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGM 892
             |.|  ||     .|.....:|..|.:.|.|.....:|.|        ...|.|......||:.:
Zfish   925 -TTR--PKRDYEVDGRDYHFMASREQMEKDIQEHKFIEAG--------QYNDNLYGTSVQSVKYV 978

  Fly   893 PLSHATSLLQNLGDLVD-LKILRSHDLANGSHLPQTQAIYAKVQRRPRSPSANTEASK 949
            .......:|...|:.:. |::.:.:.:          ||:.|    |||..:..|.:|
Zfish   979 AERGKHCILDVSGNAIKRLQVAQLYPI----------AIFIK----PRSIESLMEMNK 1022

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 16/65 (25%)
PDZ_signaling 183..254 CDD:238492 22/77 (29%)
PDZ_signaling 278..375 CDD:238492 22/108 (20%)
PDZ 496..>521 CDD:294084 3/27 (11%)
PDZ_signaling 571..658 CDD:238492 29/90 (32%)
PDZ_signaling 832..913 CDD:238492 18/86 (21%)
PDZ_signaling 973..1055 CDD:238492
dlg2XP_009303676.1 L27_1 4..62 CDD:286187
MAGUK_N_PEST 178..280 CDD:287565 25/132 (19%)
PDZ_signaling 281..365 CDD:238492 26/121 (21%)
PDZ_signaling 374..459 CDD:238492 19/116 (16%)
PDZ_assoc 461..526 CDD:287558 15/126 (12%)
PDZ_signaling 609..687 CDD:238492 30/94 (32%)
SH3_DLG2 739..812 CDD:212965 11/72 (15%)
Guanylate_kin 884..1070 CDD:279019 33/171 (19%)
GuKc 895..1070 CDD:214504 29/158 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23119
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.010

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