DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip and ptpn4b

DIOPT Version :9

Sequence 1:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	XP_005174003.1	Gene:	ptpn4b / 407634	ZFINID:	ZDB-GENE-030131-6259	Length:	935	Species:	Danio rerio

Alignment Length:	450	Identity:	91/450 - (20%)
Similarity:	157/450 - (34%)	Gaps:	134/450 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   644 NPSHSSSDFTT-------LTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSA 701
            :|.||:|.|||       .:|..:|  |.:...||    |             .|.|:|...||.
Zfish   399 SPDHSNSVFTTEGARIRPSSIGHLV--DHVIDDSP----C-------------QTFTNHKSASST 444

  Fly   702 YVTAGKYADCVSLKSRTPQPDYFRVPSMDD--ASLQSVQLRSGS-GSNGGNQAANSWSTGVNSRS 763
                  .|:.:||.| ||.||.    :.|:  .:|...|.|... ..||.:|:.:
Zfish   445 ------QANSISLDS-TPSPDV----TTDEQPPALPPKQFRKDPLNHNGRSQSQH---------- 488

  Fly   764 YVAPPNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPMENKVYGSAASSSSKSSGSSL 828
                            |.|:.:.:                      :::|...|:|....:|:..
Zfish   489 ----------------ELDDHDHL----------------------SELYNVPAASGKSMNGAVP 515

  Fly   829 HQIIFTVRLEP-KGGLLGITLAGSEDITKSITISGLVEGGIAHK-NGQIHVGDQLLAID-----E 886
            |..:..:::.| :.|..|..:.|..|....|.:|.:..|..|.. ..:::.|||::.|:     :
Zfish   516 HDNLVLIKMRPDENGRFGFNVKGGVDQRMPIIVSRVAPGTPADMCVPRLNEGDQVVLINGRDISD 580

  Fly   887 HSVQGMPLSHATSLLQNLGDLVDLKILRSHDLANGSHLPQTQAIY------AKVQRRP---RSPS 942
            |:...:.:....|.....|:|:              .|.:..|||      .|:...|   ..|.
Zfish   581 HTHDDVVMIIKASCEDQSGELI--------------LLVRPNAIYDVDEEQEKLDLEPDFQYIPE 631

  Fly   943 A-NTEASKESGSGNANGGGAVNGNSGSGKPRVFHVTLYKDKVYDDYGFSVSDGLYERGVFINRIR 1006
            | ..|:..|:.|..::.....:|.:....|..|. .||:.:.    |.|:|.....:.|..||.|
Zfish   632 ACGLESHSEADSLRSSIQLLRDGLASGTVPAQFD-QLYRKRP----GMSMSCARLPQNVSKNRYR 691

  Fly  1007 SGGPADMCG-LLKPFDRIMQVN--------EMKTQDFDCCLTVPLIAAAGDKIEMIMQRS 1057
            ...|.|... :||..:..:..|        :.:.:.:..| ..||.....|..:|:.::|
Zfish   692 DISPYDSTRVVLKGTEDYINANFINMDVPSKGEVRRYIAC-QGPLPGTCSDFWQMVWEQS 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ	82..147	CDD:294084
		PDZ_signaling	183..254	CDD:238492
		PDZ_signaling	278..375	CDD:238492
		PDZ	496..>521	CDD:294084
		PDZ_signaling	571..658	CDD:238492	7/20 (35%)
		PDZ_signaling	832..913	CDD:238492	17/87 (20%)
		PDZ_signaling	973..1055	CDD:238492	20/90 (22%)
ptpn4b	XP_005174003.1	B41	30..222	CDD:214604
		FERM_N	33..97	CDD:286467
		FERM_B-lobe	122..214	CDD:271216
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010
		FA	325..365	CDD:285894
		PDZ_signaling	519..606	CDD:238492	18/100 (18%)
		PTPc	662..915	CDD:214550	20/94 (21%)
		PTPc	687..914	CDD:238006	13/64 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900