Protein Alignment Grip and dlg4b

DIOPT Version :10

• Sequence 1: NP_572285.2
• Gene: Grip / 50391
• FlyBaseID: FBgn0029830
• Length: 1058
• Species: Drosophila melanogaster
• Sequence 2: XP_073794325.1
• Gene: dlg4b / 405796
• ZFINID: ZDB-GENE-040628-3
• Length: 831
• Species: Danio rerio
• Alignment Length: 845
• Identity: 176/845 - (20%)
• Similarity: 301/845 - (35%)
• Gaps: 229/845 - (27%)

  Fly    24 DQQQQQQQQQESHNNSFNGH---------HHPPTDTALAPML----SVDRAMSPAQSEDS----G 71
            :|||.:.|...|...|| .|         ..|.:..:|...|    :.:|..:.|:.|::    |
Zfish     9 EQQQPRCQGNRSQPASF-AHVSTRVSCCCSRPRSRLSLPRELRDGRATERERARARGEEARQAEG 72

  Fly    72 LAPERGTTYATIT-LPRNALHLAITFAER---NDLSYPPVVGSLNP----VGHAADFLAPGDRLH 128
            ...|.|...|.:: |..:...|.|...::   :|...||:..|  |    .|.:|:.|..||..|
Zfish    73 QTGEGGGDSARLSPLSPDMDCLCIVTTKKYRYHDEETPPLQHS--PAHLSTGKSAEMLHLGDSGH 135

  Fly   129 -QIDGIST----IGLSNQKVMNMLCAG------------GSDACPAIVEIEYSLPECTVSQNSLC 176
             .||||..    :.:|..|.: :|.:|            |.|.     ::||.
Zfish   136 APIDGIHAYTPQMHVSPAKPV-LLPSGHAPYYATSTLMNGMDG-----DVEYE------------ 182

  Fly   177 VTSKLAQITVERESGCLGLTLRGGADYP-------LIVTHVRPHGPVYKTGRIKPGDRLLRVDNV 234
                  :||:||.:..||.::.||.|.|       :.:|.:.|.|...:.||::..|.:|.|::|
Zfish   183 ------EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNDV 241

  Fly   235 SLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCNYT 299
            .:...|.:.|.:.:|..|.:.....|..:.....:..::...||          ..||..:
Zfish   242 DVREVTHSFAVEALKEAGPIVRLYVLRHKPSAEKITELKLIKGP----------KGLGFSI---- 292

  Fly   300 AAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDE 364
                |.|.|:      :.:.....:::..|:....|.:.|.|.:||::|::::..:|. ....|.
Zfish   293 ----AGGVGN------QHVPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNNMYLEE-VMHEDA 346

  Fly   365 VMTILDTSTGRGYTQMQIMPAHALARRGH---------TTLGSPKYSFSTLESRKSSTAGRQRQR 420
            |..:.:|.     ..:.:..|..|.:..|         |:..||....|......|.::.|
Zfish   347 VAALKNTG-----DVVFLRVAKTLHQHHHQDAYNPPDITSSYSPHMDMSDYPQALSPSSPR---- 402

  Fly   421 FARKSSLP----LENPACGTPGSTGGSMGTGGIH-GSSSLGMGLGLCRAESFPVLLDCSHGAGII 480
              |.|.:|    |::.....|...       .|| ||:.||..:
Zfish   403 --RYSPIPKGLFLDDDISREPRRV-------VIHRGSTGLGFNI--------------------- 437

  Fly   481 LSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKM---YSLDAAAMRQLLEGGSSRN 542
                |.|..|.| :.|:.|:....||.||.::.||:|:::|.:   ::....|...|...|.:..
Zfish   438 ----VGGEDGEG-IFISFILAGGAADLSGELRKGDQILSVNGVDLRHATHEQAAAALKNAGQTVT 497

  Fly   543 GASNGTPANWLELEIEF-DMPDAVVPASGVFSVKLLRAGKCGLGL----SVSGSSHGGLVISDVK 602
            ..:...|..:...|.:. |:.:.::.:|.|.:...||:||....:    ....::.||.:...|
Zfish   498 IITQYRPEEYSRFEAKIHDLREQLMNSSLVSAAASLRSGKRSFFIRALFDYDKTADGGFLSQAV- 561

  Fly   603 MGSPAHRSGSLRSGDILLAVDQHPVQHFNVDAL-----LKEEG------------------RSQN 644
                     |.|.||:|...|....:.:....|     |:|.|                  |.:.
Zfish   562 ---------SFRFGDVLQVFDCSDEEWWQAGKLAPHGELEETGYIPSKRRVERKEWSRLKTRGRE 617

  Fly   645 PSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYA 709
            |....||:       ||..:.:..|...|:. |.  |.||..   ....:.||.|.   ...|:.
Zfish   618 PVSGRSDY-------IVSYETVTQSEVHYAR-PV--IILGPS---KDRVNDDLLSE---FPDKFG 666

  Fly   710 DCVSLKSRTPQPDYFRVPSMDDASLQSV--------QLRSGSGSNGGNQAANSWSTGVNSRSYVA 766
            .||...:| |:.:|    .||......|        .::|......|...::.:.|.|.|...||
Zfish   667 SCVPHTTR-PKREY----EMDGRDYHFVSSREQMEKDIQSHRFIEAGQYNSHLYGTSVQSVRQVA 726

  Fly   767  766
            Zfish   727  726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip	NP_572285.2	PDZ_canonical	<96..163	CDD:483948	21/90 (23%)
		PDZ2_GRIP1-2-like	180..265	CDD:467169	24/91 (26%)
		PDZ3_GRIP1-2-like	277..384	CDD:467172	18/106 (17%)
		degP_htrA_DO	<491..659	CDD:273938	40/198 (20%)
		PDZ_canonical	572..>623	CDD:483948	12/54 (22%)
		PDZ6_GRIP1-2-like	830..914	CDD:467171
		PDZ7_GRIP1-2-like	971..1056	CDD:467173
dlg4b	XP_073794325.1	None