DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Grip and dlg4b

DIOPT Version :9

Sequence 1:NP_572285.2 Gene:Grip / 50391 FlyBaseID:FBgn0029830 Length:1058 Species:Drosophila melanogaster
Sequence 2:NP_999893.1 Gene:dlg4b / 405796 ZFINID:ZDB-GENE-040628-3 Length:801 Species:Danio rerio


Alignment Length:787 Identity:157/787 - (19%)
Similarity:271/787 - (34%) Gaps:224/787 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 FNGHHHPPTDTALAPMLSVDRAMSPAQSEDSGLAPERGTTYATITLPRNALHLAITFAERNDLSY 104
            ::....||...:.| .||..::.......|||.||..|....|   |:  :|::           
Zfish    74 YHDEETPPLQHSPA-HLSTGKSAEMLHLGDSGHAPIDGIHAYT---PQ--MHVS----------- 121

  Fly   105 PPVVGSLNPVGHAADFLAPGDRLHQIDGISTIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECT 169
             |....|.|.|| |.:.|....::.:||                           ::||.     
Zfish   122 -PAKPVLLPSGH-APYYATSTLMNGMDG---------------------------DVEYE----- 152

  Fly   170 VSQNSLCVTSKLAQITVERESGCLGLTLRGGADYP-------LIVTHVRPHGPVYKTGRIKPGDR 227
                         :||:||.:..||.::.||.|.|       :.:|.:.|.|...:.||::..|.
Zfish   153 -------------EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDS 204

  Fly   228 LLRVDNVSLIGKTLAEAQQIIKCGGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLG 292
            :|.|::|.:...|.:.|.:.:|..|.:.....|..:.....:..::...||          ..||
Zfish   205 ILFVNDVDVREVTHSFAVEALKEAGPIVRLYVLRHKPSAEKITELKLIKGP----------KGLG 259

  Fly   293 LVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIEH 357
            ..:        |.|.|:      :.:.....:::..|:....|.:.|.|.:||::|::::..:|.
Zfish   260 FSI--------AGGVGN------QHVPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNNMYLEE 310

  Fly   358 TAFSPDEVMTILDTSTGRGYTQMQIMPAHALARRGH---------TTLGSPKYSFSTLESRKSST 413
             ....|.|..:.:|.     ..:.:..|..|.:..|         |:..||....|......|.:
Zfish   311 -VMHEDAVAALKNTG-----DVVFLRVAKTLHQHHHQDAYNPPDITSSYSPHMDMSDYPQALSPS 369

  Fly   414 AGRQRQRFARKSSLP----LENPACGTPGSTGGSMGTGGIH-GSSSLGMGLGLCRAESFPVLLDC 473
            :.|      |.|.:|    |::.....|...       .|| ||:.||..:              
Zfish   370 SPR------RYSPIPKGLFLDDDISREPRRV-------VIHRGSTGLGFNI-------------- 407

  Fly   474 SHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKM---YSLDAAAMRQLL 535
                       |.|..|.| :.|:.|:....||.||.::.||:|:::|.:   ::....|...|.
Zfish   408 -----------VGGEDGEG-IFISFILAGGAADLSGELRKGDQILSVNGVDLRHATHEQAAAALK 460

  Fly   536 EGGSSRNGASNGTPANWLELEIEF-DMPDAVVPASGVFSVKLLRAGKCGLGL----SVSGSSHGG 595
            ..|.:....:...|..:...|.:. |:.:.::.:|.|.:...||:||....:    ....::.||
Zfish   461 NAGQTVTIITQYRPEEYSRFEAKIHDLREQLMNSSLVSAAASLRSGKRSFFIRALFDYDKTADGG 525

  Fly   596 LVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDAL-----LKEEG--------------- 640
            .:...|          |.|.||:|...|....:.:....|     |:|.|               
Zfish   526 FLSQAV----------SFRFGDVLQVFDCSDEEWWQAGKLAPHGELEETGYIPSKRRVERKEWSR 580

  Fly   641 ---RSQNPSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAY 702
               |.:.|....||:       ||..:.:..|...|:. |.  |.||..   ....:.||.|.  
Zfish   581 LKTRGREPVSGRSDY-------IVSYETVTQSEVHYAR-PV--IILGPS---KDRVNDDLLSE-- 630

  Fly   703 VTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSV--------QLRSGSGSNGGNQAANSWSTGV 759
             ...|:..||...:| |:.:|    .||......|        .::|......|...::.:.|.|
Zfish   631 -FPDKFGSCVPHTTR-PKREY----EMDGRDYHFVSSREQMEKDIQSHRFIEAGQYNSHLYGTSV 689

  Fly   760 NSRSYVA 766
            .|...||
Zfish   690 QSVRQVA 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GripNP_572285.2 PDZ 82..147 CDD:294084 12/64 (19%)
PDZ_signaling 183..254 CDD:238492 23/77 (30%)
PDZ_signaling 278..375 CDD:238492 17/96 (18%)
PDZ 496..>521 CDD:294084 9/24 (38%)
PDZ_signaling 571..658 CDD:238492 22/113 (19%)
PDZ_signaling 832..913 CDD:238492
PDZ_signaling 973..1055 CDD:238492
dlg4bNP_999893.1 L27_1 4..58 CDD:286187
MAGUK_N_PEST 71..152 CDD:287565 24/123 (20%)
PDZ 153..237 CDD:278991 23/83 (28%)
PDZ 245..331 CDD:214570 18/115 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 339..373 7/39 (18%)
PDZ_assoc 342..392 CDD:287558 10/55 (18%)
PDZ_signaling 391..471 CDD:238492 24/112 (21%)
SH3 509..574 CDD:302595 13/74 (18%)
Guanylate_kin 609..788 CDD:279019 24/102 (24%)
GuKc 617..788 CDD:214504 20/91 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23119
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.010

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